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Author Details

Kevin R Brown
College Street, University of Toronto
2000
62
28
PMIDPaper TitleJournal TitlePublished Year
36627300Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.Nat Commun2023
36597481Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors.Heliyon2023
34911733Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer.Cancer Discov2022
36473869Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.Nat Commun2022
36368321Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.Cancer Cell2022
36170831Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma.Cell Rep2022
35914530Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis.Mol Cell2022
35017149CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment.J Immunother Cancer2022
33417860Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.Cell2021
33561012Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer.J Clin Invest2021
34765972Identification of five important genes to predict glioblastoma subtypes.Neurooncol Adv2021
34508259Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline.Nat Protoc2021
34018332A method for benchmarking genetic screens reveals a predominant mitochondrial bias.Mol Syst Biol2021
33962950NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4.Sci Adv2021
32429240A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids.Cancers (Basel)2020
33138032RAD51-Mediated DNA Homologous Recombination Is Independent of <i>PTEN</i> Mutational Status.Cancers (Basel)2020
32968282Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.Nature2020
32938917Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.Nat Commun2020
32572160Functional genomics identifies new synergistic therapies for retinoblastoma.Oncogene2020
32694731Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.Nat Metab2020
32249828Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform.Nat Biotechnol2020
30696911A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.Sci Rep2019
31464370CRISPR screens are feasible in TP53 wild-type cells.Mol Syst Biol2019
31545321Pooled CRISPR-Based Genetic Screens in Mammalian Cells.J Vis Exp2019
31566424Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.Am J Physiol Renal Physiol2019
31115870Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.J Neurooncol2019
30970261Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.Cell Rep2019
30523157Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.J Biol Chem2019
29945963Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.Cancer Res2018
27835861An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.Oncotarget2017
28273451Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.Cell Rep2017
28423708Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.Oncotarget2017
29117169Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nat Med2017
28766011RNAi screen identifies essential regulators of human brain metastasis-initiating cells.Acta Neuropathol2017
28655737Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.G3 (Bethesda)2017
27869803Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nat Med2017
26949039System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Mol Cell2016
27422173Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine.BMC Cancer2016
26771497Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.Cell2016
26297733Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.Cancer Res2015
26627737High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Cell2015
26353928Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.Oncotarget2015
24987113Measuring error rates in genomic perturbation screens: gold standards for human functional genomics.Mol Syst Biol2014
23797109Miniature short hairpin RNA screens to characterize antiproliferative drugs.G3 (Bethesda)2013
24104479A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.Mol Syst Biol2013
23851435Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma.Pancreas2013
22102578COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.Nucleic Acids Res2012
22585861Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Cancer Discov2012
22645275Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.Hum Mol Genet2012
21548937A comprehensive platform for highly multiplexed mammalian functional genetic screens.BMC Genomics2011
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Stephen J Elledge
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David J Adams
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Francisca Vazquez
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Collaborators

Jason Moffat
University of Toronto
Co-authored papers 41
Igor Jurisica
Schroeder Arthritis Institute
Co-authored papers 10
Sheila K Singh
McMaster University
Co-authored papers 10
Chitra Venugopal
McMaster Stem Cell and Cancer Research Institute
Co-authored papers 8
Traver Hart
University of Texas MD Anderson Cancer Center
Co-authored papers 8
Chirayu Chokshi
McMaster University
Co-authored papers 8
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 7
Chad L Myers
University of Minnesota - Twin Cities
Co-authored papers 6
Amy Hin Yan Tong
University of Toronto
Co-authored papers 6
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 5
Charles Boone
University of Toronto
Co-authored papers 4
Benjamin J Blencowe
University of Toronto
Co-authored papers 4
Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 4
Brenda J Andrews
University of Toronto
Co-authored papers 4
Zachary Steinhart
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 3
Gary D Bader
University of Toronto
Co-authored papers 3
J??ri Reimand
Ontario Institute for Cancer Research
Co-authored papers 3
Alessandro Datti
University of Perugia
Co-authored papers 3
Laurie Ailles
University of Toronto
Co-authored papers 3
Hong Han
Hangzhou City University
Co-authored papers 3
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 3
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 3
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Igor Stagljar
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 2
Ronny Drapkin
University of Pennsylvania School of Medicine
Co-authored papers 2
Arvind Singh Mer
University of Ottawa
Co-authored papers 2
John Provias
McMaster University
Co-authored papers 2
Marc Remke
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 2
Housheng Hansen He
Princess Margaret Cancer Center, University Health Network, University of Toronto
Co-authored papers 2
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Release 1.2