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Author Details

Aaron D Schimmer
Princess Margaret Cancer Centre
1989
280
58
PMIDPaper TitleJournal TitlePublished Year
37345484Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia.Haematologica2024
37941406Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase.Haematologica2024
36355853Applying CRISPR-Cas9 screens to dissect hematological malignancies.Blood Adv2023
37801638Total Synthesis of the 2,5-Disubstituted γ-Pyrone E1 UAE Inhibitor Himeic Acid A.Org Lett2023
37498585ZDHHC21: a mitochondrial vulnerability in AML.Blood2023
36732677Mutational profile, outcomes, and impact of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia and inconclusive cytogenetic analysis.Eur J Haematol2023
36794878Venous thromboembolism incidence associated with pegylated asparaginase (ASP) compared to the native L-ASP: A retrospective analysis with an ASP-based protocol in adult patients with acute lymphoblastic leukaemia.Br J Haematol2023
36481232Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis.Trends Cell Biol2023
35165102Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer.Clin Cancer Res2022
35668135The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.Nat Cell Biol2022
35667842Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8<sup>+</sup> T Cell Proliferation.J Immunol2022
35492819Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations.JACC CardioOncol2022
35365596Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.Signal Transduct Target Ther2022
35385187Allogeneic double-negative T cell therapy for relapsed acute myeloid leukemia patients post allogeneic hematopoietic stem cell transplantation: A first-in-human phase I study.Am J Hematol2022
36819167Safety of re-challenging adults with acute lymphoblastic leukemia with PEG-asparaginase-induced severe hypertriglyceridemia when treated with a pediatric-inspired regimen.EJHaem2022
36407947Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer.ACS Pharmacol Transl Sci2022
36332954Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study.BMJ Open2022
36321400What doesn't kill you makes you stronger - <i>bcl-2</i> promotes survival independent of proliferation.Haematologica2022
36084291Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.ACS Chem Biol2022
35185150Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.Signal Transduct Target Ther2022
35169231Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.Commun Biol2022
33177128E1 Enzymes as Therapeutic Targets in Cancer.Pharmacol Rev2021
33720355Very long chain fatty acid metabolism is required in acute myeloid leukemia.Blood2021
33767401Prognostic impact of the adverse molecular-genetic profile on long-term outcomes following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.Bone Marrow Transplant2021
33594052Biological and therapeutic implications of a unique subtype of NPM1 mutated AML.Nat Commun2021
33922062Mitochondrial ATP-Dependent Proteases-Biological Function and Potential Anti-Cancer Targets.Cancers (Basel)2021
33504581Mitochondrial and Metabolic Pathways Regulate Nuclear Gene Expression to Control Differentiation, Stem Cell Function, and Immune Response in Leukemia.Cancer Discov2021
34616866Novel subtypes of <i>NPM1</i>-mutated AML with distinct outcome.Mol Cell Oncol2021
34292323Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production.Blood2021
34031589Mammary epithelial cells have lineage-rooted metabolic identities.Nat Metab2021
31896684Measurable residual disease monitoring provides insufficient lead-time to prevent morphologic relapse in the majority of patients with core-binding factor acute myeloid leukemia.Haematologica2021
31857370Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia.Haematologica2021
33476303A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.JCI Insight2021
31001692Emotion And Symptom-focused Engagement (EASE): a randomized phase II trial of an integrated psychological and palliative care intervention for patients with acute leukemia.Support Care Cancer2020
33704181Risk of Thrombosis in Adult Philadelphia-Positive ALL Treated with an Asparaginase-Free ALL Regimen.Curr Oncol2020
33377057Transduction of Primary AML Cells with Lentiviral Vector for <i>In Vitro</i> Study or <i>In Vivo</i> Engraftment.STAR Protoc2020
33241109Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism.Mol Cell Oncol2020
33037181Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy.Cell Death Dis2020
32609586Screening for Dental Infections Achieves 6-Fold Reduction in Dental Emergencies During Induction Chemotherapy for Acute Myeloid Leukemia.JCO Oncol Pract2020
32944624Targeting neurolysin in acute myeloid leukemia.Mol Cell Oncol2020
32996267COVID-19: a pandemic experience that illuminates potential reforms to health research.EMBO Mol Med2020
32624581Targeting nuclear import and export in hematological malignancies.Leukemia2020
32761807The role of mitochondrial proteases in leukemic cells and leukemic stem cells.Stem Cells Transl Med2020
32749766Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death.Mol Oncol2020
32416059Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.Cell Stem Cell2020
32269163The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.Sci Transl Med2020
32299104Mitochondrial carrier homolog 2 is necessary for AML survival.Blood2020
32484839Correction: The Natural Pesticide Dihydrorotenone Induces Human Plasma Cell Apoptosis by Triggering Endoplasmic Reticulum Stress and Activating p38 Signaling Pathway.PLoS One2020
32395867Anticoagulation prophylaxis reduces venous thromboembolism rate in adult acute lymphoblastic leukaemia treated with asparaginase-based therapy.Br J Haematol2020
30535882Pain in patients with newly diagnosed or relapsed acute leukemia.Support Care Cancer2019
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Collaborators

Princess Margaret Cancer Centre
Co-authored papers 63
Princess Margaret Cancer Centre
Co-authored papers 54
University of Perugia
Co-authored papers 20
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 19
Princess Margaret Cancer Centre
Co-authored papers 17
Toronto General Hospital, University Health Network, University of Toronto
Co-authored papers 16
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 15
Princess Margaret Cancer Centre (University Health Network)
Co-authored papers 12
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
The Hospital for Sick Children, University Avenue
Co-authored papers 11
University of Toronto
Co-authored papers 11
Co-authored papers 9
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 9
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
University of Toronto
Co-authored papers 7
The Scripps Research Institute
Co-authored papers 7
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 7
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 7
Princess Margaret Cancer Centre, Ontario Cancer Institute
Co-authored papers 7
University of Waterloo, University Avenue West
Co-authored papers 6
University of Toronto
Co-authored papers 6
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
University of Toronto
Co-authored papers 5
University of Toronto
Co-authored papers 5
Memorial Sloan-Kettering Cancer Center
Co-authored papers 4
University of Toronto
Co-authored papers 4
MD Anderson Cancer Center
Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
Dana-Farber Cancer Institute
Co-authored papers 4