Author details

Full Name

Randolph Y Hampton

Affiliation

University of California San Diego

ORCID

Career Start Year

1980

Papers

H Index

Expertise

CM4AI Collaborator

Trey Ideker (CM4AI)

PMID	Paper Title	Journal Title	Published Year
37729018	Exploring the "misfolding problem" by systematic discovery and analysis of functional-but-degraded proteins.	Mol Biol Cell	2023
33184059	An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase.	J Biol Chem	2021
33566711	Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity.	Mol Biol Cell	2021
32966159	Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control.	Mol Biol Cell	2020
32891886	HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation.	iScience	2020
30910017	Assays for protein retrotranslocation in ERAD.	Methods Enzymol	2019
31074531	Integrating after CEN Excision (ICE) Plasmids: Combining the ease of yeast recombination cloning with the stability of genomic integration.	Yeast	2019
29351850	Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping.	Mol Cell	2018
30018140	"Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD.	J Biol Chem	2018
29499140	The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.	Mol Cell	2018
29351849	The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.	Mol Cell	2018
28774913	New developments for protein quality control.	Science	2017
28077573	A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.	J Biol Chem	2017
28992438	Proteostatic Tactics in the Strategy of Sterol Regulation.	Annu Rev Cell Dev Biol	2017
27170191	Direct and essential function for Hrd3 in ER-associated degradation.	Proc Natl Acad Sci U S A	2016
27270400	Control of the innate immune response by the mevalonate pathway.	Nat Immunol	2016
26051182	The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins.	Mol Cell	2015
23306196	Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.	J Biol Chem	2013
22854296	Finding the will and the way of ERAD substrate retrotranslocation.	Curr Opin Cell Biol	2012
22829918	Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p.	PLoS One	2012
21211716	San1-mediated quality control: substrate recognition "sans" chaperones.	Mol Cell	2011
21628456	The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.	J Biol Chem	2011
20080635	Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1.	Proc Natl Acad Sci U S A	2010
19940128	Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.	J Biol Chem	2010
19243134	Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway.	Chem Rev	2009
19776008	Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.	J Biol Chem	2009
19394298	Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase.	Mol Cell	2009
19324879	In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase.	J Biol Chem	2009
18321851	Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo.	J Biol Chem	2008
19041760	A cholesterol toggle switch.	Cell Metab	2008
18667535	Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.	Mol Biol Cell	2008
17893151	Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.	J Biol Chem	2007
17083136	Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.	Yeast	2006
17035235	Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase.	J Biol Chem	2006
15738968	Cdc48-Ufd2-Rad23: the road less ubiquitinated?	Nat Cell Biol	2005
16270032	INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.	EMBO J	2005
16338365	Fusion-based strategies to identify genes involved in degradation of a specific substrate.	Methods Enzymol	2005
15875007	Cell biology: sterol sensor comes up for air.	Nature	2005
15975777	The dynamic ER: experimental approaches and current questions.	Curr Opin Cell Biol	2005
15635451	Lipid-mediated, reversible misfolding of a sterol-sensing domain protein.	EMBO J	2005
14570925	Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase.	J Biol Chem	2004
15550643	Varshavsky's contributions.	Science	2004
15479733	Membrane biogenesis and the unfolded protein response.	J Cell Biol	2004
12586055	IRE1: a role in UPREgulation of ER degradation.	Dev Cell	2003
12058017	Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis.	J Cell Biol	2002
12383799	ER-associated degradation in protein quality control and cellular regulation.	Curr Opin Cell Biol	2002
12142284	Proteolysis and sterol regulation.	Annu Rev Cell Dev Biol	2002
12015140	Cdc48-Ufd1-Npl4: stuck in the middle with Ub.	Curr Biol	2002
11146622	Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.	Nat Cell Biol	2001
11739805	HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins.	Mol Biol Cell	2001

1 - 50 of 82

Martin Mehnert

Institute of Molecular Systems Biology, ETH Zurich

Career Start Year 2010

Number of shared co-authors 0

Franziska Kriegenburg

Institute of Biochemistry and Molecular Biology, University of Freiburg

Career Start Year 2008

Number of shared co-authors 0

Aeid Igbaria

Inserm U2, University of Rennes

Career Start Year 2007

Number of shared co-authors 0

Vladimir Denic

Harvard University

Career Start Year 2005

Number of shared co-authors 2

Jeffrey R Johnson

Gladstone Institutes

Career Start Year 2001

Number of shared co-authors 4

Jeroen A A Demmers

Erasmus Medical Center

Career Start Year 2000

Number of shared co-authors 0

Maya Schuldiner

The Weizmann Institute of Science

Career Start Year 2000

Number of shared co-authors 3

Tobias C Walther

Harvard T. H. Chan School of Public Health

Career Start Year 1999

Number of shared co-authors 1

Rasmus Hartmann-Petersen

University of Copenhagen

Career Start Year 1998

Number of shared co-authors 0

Yihong Ye

National Institute of Diabetes, National Institutes of Health

Career Start Year 1998

Number of shared co-authors 1

Elah Pick

University of Haifa

Career Start Year 1998

Number of shared co-authors 0

Yien Che Tsai

Center for Cancer Research, National Institutes of Health

Career Start Year 1997

Number of shared co-authors 1

James A Wohlschlegel

David Geffen School of Medicine, University of California Los Angeles

Career Start Year 1996

Number of shared co-authors 1

Brian Raught

Princess Margaret Cancer Centre, University Health Network

Career Start Year 1994

Number of shared co-authors 3

Igor Stagljar

University of Toronto, Canada Mediterranean Institute for Life Sciences

Career Start Year 1993

Number of shared co-authors 2

Jens S Andersen

University of Southern Denmark

Career Start Year 1993

Number of shared co-authors 1

Ivan Dikic

Institute of Biochemistry II, Goethe University Frankfurt

Career Start Year 1992

Number of shared co-authors 3

Peter J Espenshade

Johns Hopkins University School of Medicine

Career Start Year 1992

Number of shared co-authors 1

Jonathan S Weissman

Whitehead Institute for Biomedical Research

Career Start Year 1991

Number of shared co-authors 4

Steven P Gygi

Harvard Medical School

Career Start Year 1991

Number of shared co-authors 2

Christopher G Burd

Yale School of Medicine

Career Start Year 1989

Number of shared co-authors 4

John D Aitchison

Center for Global Infectious Disease Research, Seattle Children's Research Institute

Career Start Year 1988

Number of shared co-authors 2

Ineke Braakman

Utrecht University

Career Start Year 1987

Number of shared co-authors 0

Hediye Erdjument-Bromage

Neuroscience Institute, NYU Grossman School of Medicine

Career Start Year 1984

Number of shared co-authors 2

J. Wade Harper

Harvard Medical School

Career Start Year 1981

Number of shared co-authors 4

Richard A Rachubinski

University of Alberta

Career Start Year 1980

Number of shared co-authors 3

Robert Ernst

Saarland University, Center for Molecular Signaling

Career Start Year 1978

Number of shared co-authors 0

Peter Walter

University of California san francisco

Career Start Year 1977

Number of shared co-authors 1

Suresh Subramani

University of California San Diego

Career Start Year 1975

Number of shared co-authors 3

John R Yates

TheScripps Research Institute

Career Start Year 1960

Number of shared co-authors 5

row(s) 1 - 30 of 30

Christian R H Raetz

Co-authored papers 8

Sonya E Neal

University of California San Diego, United States Howard Hughes Medical Institute

Co-authored papers 7

Jasper Rine

University of California berkeley

Co-authored papers 4

Sascha H Duttke

College of Veterinary Medicine, Washington State University

Co-authored papers 4

Philipp A Jaeger

University of California

Co-authored papers 3

Trey Ideker (CM4AI)

University of California San Diego

Co-authored papers 3

Christopher Benner

Michigan State University College of Human Medicine

Co-authored papers 3

David Ron

Cambridge Institute for Medical Research, University of Cambridge

Co-authored papers 2

Christopher K Glass

University of California San Diego

Co-authored papers 2

Wolfgang Baumeister

Max Planck Institute of Biochemistry

Co-authored papers 2

Chandra L Theesfeld

Lewis-Sigler Institute for Integrative Genomics, Princeton University

Co-authored papers 2

Pamela A Silver

Harvard Medical School

Co-authored papers 1

Cameron McElfresh

University of California los angeles

Co-authored papers 1

Charles Boone

University of Toronto

Co-authored papers 1

James E Haber

Brandeis University

Co-authored papers 1

Alexandra C Newton

Co-authored papers 1

Neal Silverman

Co-authored papers 1

Allan M Weissman

Center for Cancer Research, National Institutes of Health

Co-authored papers 1

Catherine Dargemont

Institute of Human Genetics, UMR 9002 CNRS - University of Montpellier

Co-authored papers 1

Peter K Jackson

Stanford University School of Medicine, Center for Clinical Sciences Research

Co-authored papers 1

Scott D Emr

Weill Institute for Cell and Molecular Biology, Cornell University

Co-authored papers 1

Lilia Ornelas

University of California

Co-authored papers 1

Amy Hin Yan Tong

University of Toronto

Co-authored papers 1

Katherine A Fitzgerald

Co-authored papers 1

Gwendolyn M Swarbrick

Oregon Health and Science University

Co-authored papers 1

Mike Tyers

Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal

Co-authored papers 1

Daniel Chen

Shiley Eye Institute, University of California San Diego

Co-authored papers 1

Daniel L Kastner

Co-authored papers 1

Lily R Wong

San Jose State University

Co-authored papers 1

1 - 29

Author Details

Column Actions

Recommended Authors

Collaborators