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Author Details

Michael C Ostrowski
Hollings Cancer Center, Medical University of South Carolina
1979
176
62
PMIDPaper TitleJournal TitlePublished Year
36596776The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.Nat Commun2023
37315788Hepatic protein kinase Cbeta deficiency mitigates late-onset obesity.J Biol Chem2023
37399416Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.Proc Natl Acad Sci U S A2023
36868225Cancer cachexia: involvement of an expanding macroenvironment.Cancer Cell2023
33949915Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.Small GTPases2022
35803738STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.Life Sci Alliance2022
35533313Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner.Mol Cancer Res2022
35459474Preface.Adv Cancer Res2022
35459469Origin, activation and heterogeneity of fibroblasts associated with pancreas and breast cancers.Adv Cancer Res2022
32327406Stromal Platelet-Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain.Cancer Res2021
33534863Pten regulates collagen fibrillogenesis by fibroblasts through SPARC.PLoS One2021
34622807Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesis.JCI Insight2021
34503228Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry.Cancers (Basel)2021
34103528PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.Nat Commun2021
34118960The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.Breast Cancer Res2021
33271332Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis.Mol Metab2021
32924017Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia.Blood Cancer Discov2020
30670148Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition.BMB Rep2019
31213464Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.Cancer Res2019
31182750Nanofiber-expanded human CD34<sup>+</sup> cells heal cutaneous wounds in streptozotocin-induced diabetic mice.Sci Rep2019
31427286PTEN in the Stroma.Cold Spring Harb Perspect Med2019
31390573Modeling Human Cancer-induced Cachexia.Cell Rep2019
31130414Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.Cell Rep2019
30634169Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation.iScience2019
30550871Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland.Neoplasia2019
27797936IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.Gut2018
30018330Stromal PTEN determines mammary epithelial response to radiotherapy.Nat Commun2018
30297868Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair.Cell Res2018
30456390Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.Life Sci Alliance2018
30479334PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.Nat Commun2018
29720724Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation.Oncogene2018
29440354<i>Csf1r</i>-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System.J Immunol2018
29464534A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer.Breast Cancer Res Treat2018
29592899Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.Mol Cancer Res2018
29619268Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.Bone Res2018
27797378Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.Oncogene2017
28450705The ETS family of oncogenic transcription factors in solid tumours.Nat Rev Cancer2017
28496202Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.Sci Rep2017
28501760Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.Neoplasia2017
29035387Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.Oncogene2017
28934293Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele.PLoS One2017
29021240Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.Genes Dev2017
28535374Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.Dev Cell2017
28842466IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.J Immunol2017
26218069Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.J Cell Physiol2016
26549026E2f3 in tumor macrophages promotes lung metastasis.Oncogene2016
27633013Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.Genes Dev2016
27659014Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.Neoplasia2016
26764128FGFR and PTEN signaling interact during lens development to regulate cell survival.Dev Biol2016
25376607Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies.Mol Cancer Ther2015
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Collaborators

David A Hume
Mater Research Institute-UQ, Translational Research Institute
Co-authored papers 23
Soledad Fernandez
McGill University
Co-authored papers 18
Lianbo Yu
The Ohio State University
Co-authored papers 14
Agnieszka Bronisz
Mossakowski Medical Research Institute, Polish Academy of Sciences
Co-authored papers 13
Gordon L Hager
National Cancer Institute, National Institutes of Health
Co-authored papers 6
Clay B Marsh
West Virginia University School of Medicine
Co-authored papers 5
Jianying Zhang
City of Hope National Medical Center
Co-authored papers 4
Rong Hu
Co-authored papers 4
Martine F Roussel
St. Jude Children's Research Hospital
Co-authored papers 3
Norman L Lehman
Co-authored papers 3
Michael Rehli
University Hospital Regensburg
Co-authored papers 3
Sandya Liyanarachchi
The Ohio State University Comprehensive Cancer Center, Comprehensive Cancer Center
Co-authored papers 3
Matthew D Ringel
The Ohio State University College of Medicine and Comprehensive Cancer Center
Co-authored papers 2
Peggi M Angel
Co-authored papers 2
Joel Saltz
Stony Brook University
Co-authored papers 2
Tim H-M Huang
University of Texas Health San Antonio (UTHSA)
Co-authored papers 2
Rebecca Nagy
Guardant Health Inc.
Co-authored papers 1
Peter Libby
Co-authored papers 1
Albert de la Chapelle
The Ohio State University Comprehensive Cancer Center
Co-authored papers 1
Kinga Dymecka
Co-authored papers 1
Gordon B Mills
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 1
Huiling He
The Ohio State University Comprehensive Cancer Center
Co-authored papers 1
Zbigniew Puch
M. Sklodowska-Curie National Research Institute of Oncology
Co-authored papers 1
Arvind Rao
University of Michigan-Ann Arbor
Co-authored papers 1
Yungui Huang
Research Institute at Nationwide Childrens Hospital, University of Iowa
Co-authored papers 1
Ma??gorzata Czetwerty??ska
Maria Sklodowska-Curie Institute - Oncology Centre
Co-authored papers 1
Marek Krawczyk
Medical University of Warsaw
Co-authored papers 1
Helong Zhao
Versiti Blood Research Institute and Medical College of Wisconsin
Co-authored papers 1
Keiko Akagi
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Geoffrey J Faulkner
Mater Research Institute - University of Queensland
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Release 1.2