Author details

Full Name

Mark Mercola

Affiliation

ORCID

Career Start Year

1980

Papers

170

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36563695	A deep learning platform to assess drug proarrhythmia risk.		2023
37961166	Genetic analysis and multimodal imaging identify novel mtDNA 12148T>C leading to multisystem dysfunction with tissue-specific heteroplasmy.		2023
36503723	Cellular and subcellular optogenetic approaches towards neuroprotection and vision restoration.	Prog Retin Eye Res	2023
35606425	Repurposing drugs to treat cardiovascular disease in the era of precision medicine.	Nature Reviews Cardiology	2022
35763671	Reengineering Ponatinib to Minimize Cardiovascular Toxicity.	Cancer Res	2022
36018047	Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes.	Stem cells translational medicine	2022
35637317	Phenotypic drug discovery: recent successes, lessons learned and new directions.	Nature Reviews Drug Discovery	2022
35944901	Designing Novel BCR-ABL Inhibitors for Chronic Myeloid Leukemia with Improved Cardiac Safety.	Journal of Medicinal Chemistry	2022
35688887	Publisher Correction: Phenotypic drug discovery: recent successes, lessons learned and new directions.	Nature Reviews Drug Discovery	2022
35728000	Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.	Eur Heart J	2022
34417601	Highlights from Stanford Drug Discovery Symposium 2021.	Cardiovascular Research	2021
33542270	CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes.	Sci Rep	2021
34232272	The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease.	Transl Vis Sci Technol	2021
34062251	Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs.	Bioorganic and Medicinal Chemistry Letters	2021
33742276	miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury.	Basic Res Cardiol	2021
33740432	Human iPSC modeling of heart disease for drug development.	Cell Chemical Biology	2021
33731358	Temporal mechanisms of myogenic specification in human induced pluripotent stem cells.	Sci Adv	2021
34104945	Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release.	European Heart Journal	2021
33942619	Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes.	Journal of Medicinal Chemistry	2021
34099864	Mapping genetic variability in mature miRNAs and miRNA binding sites in prostate cancer.	Journal of Human Genetics	2021
33928785	Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.	Circulation	2021
33503403	Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness.	Cell Chemical Biology	2021
34327875	Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs.	Pharmacology Research and Perspectives	2021
33816571	miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a.	Frontiers in Cardiovascular Medicine	2021
34604804	Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.	JACC: CardioOncology	2021
34648073	Cardiomyocyte Na and Ca mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors.	Basic Research in Cardiology	2021
32905764	iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy.	Cell Rep	2020
32134364	Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes.	Circulation Research	2020
32931730	Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.	Cell Stem Cell	2020
32538237	Sacubitril/Valsartan Improves Cardiac Function and Decreases Myocardial Fibrosis Via Downregulation of Exosomal miR-181a in a Rodent Chronic Myocardial Infarction Model.	Journal of the American Heart Association	2020
32925938	A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy.	PLoS Genetics	2020
32697997	Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.	Cell Rep	2020
33074758	Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome.	Circulation	2020
31346210	Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ.	Scientific Reports	2019
31849643	<i>Crataegus</i> Extract WSÂ®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?	Front Pharmacol	2019
31877162	AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes.	PLoS ONE	2019
30586709	A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.	Circulation	2019
30951657	Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening.		2019
29768213	miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway.	Cell Rep	2018
30075999	Novel tertiary sulfonamides as potent anti-cancer agents.	Bioorganic and Medicinal Chemistry	2018
30201292	b-Annulated 1,4-dihydropyridines as Notch inhibitors.	Bioorganic and Medicinal Chemistry Letters	2018
30413796	Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity.		2018
30081259	Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?	Current Opinion in Pharmacology	2018
30032112	A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer.	Cancer Research	2018
29273502	miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure.	Molecular Therapy	2018
29802473	Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function.	Current Cardiology Reports	2018
28131760	Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound.	Life Sciences	2017
28794185	Id genes are essential for early heart formation.	Genes and Development	2017
29075196	An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.	Front Physiol	2017
27940555	The CSRP2BP histone acetyltransferase drives smooth muscle gene expression.	Nucleic Acids Research	2017