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Author Details

Michael P Vitek
Duke University Medical Center
1981
164
60
PMIDPaper TitleJournal TitlePublished Year
37111572ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers.Pharmaceutics2023
36081797Apolipoprotein E mimetic peptide COG1410 combats pandrug-resistant <i>Acinetobacter baumannii</i>.Front Microbiol2022
35814385PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449.Front Oncol2022
36523654Caspase-1 and the inflammasome promote polycystic kidney disease progression.Front Mol Biosci2022
33457489Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.Alzheimers Dement (N Y)2021
34121475Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease.ASN Neuro2021
32569675Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma.Eur J Pharmacol2020
29330298Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.Mol Cancer Res2018
30225551Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice.Transl Stroke Res2018
29556174Apolipoprotein E-Mimetic Peptide COG1410 Promotes Autophagy by Phosphorylating GSK-3β in Early Brain Injury Following Experimental Subarachnoid Hemorrhage.Front Neurosci2018
27411737Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An <sup>18</sup>F-Fluorodeoxyglucose PET/CT Study.J Neurotrauma2017
28830934OP449 inhibits breast cancer growth without adverse metabolic effects.Endocr Relat Cancer2017
27796945Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.Transl Stroke Res2017
27597652Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.Ann Rheum Dis2017
26192010Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury.J Neurotrauma2016
27705940Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.Oncotarget2016
27241720An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.Neurosci Lett2016
27463015Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.Oncotarget2016
25878270Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.J Neurosci2015
26563471Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.Sci Rep2015
26062569The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma.J Vet Med Sci2015
25833944The N-terminal Set-β Protein Isoform Induces Neuronal Death.J Biol Chem2015
24436473Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.Clin Cancer Res2014
25249536[Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].Biomed Khim2014
25403885The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment.Mol Neurodegener2014
25003233mNos2 deletion and human NOS2 replacement in Alzheimer disease models.J Neuropathol Exp Neurol2014
24781014Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity.Leukemia2014
24586873Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.PLoS One2014
24667985Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.Mol Cancer Res2014
24633884ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.J Neurosci Res2014
23131782A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma.J Vet Med Sci2013
25642353Apolipoprotein E Mimetic Promotes Functional and Histological Recovery in Lysolecithin-Induced Spinal Cord Demyelination in Mice.J Neurol Neurophysiol2013
23219883ApolipoproteinE mimetic peptides improve outcome after focal ischemia.Exp Neurol2013
22965147The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features.Neurodegener Dis2013
21989844The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.Neurocrit Care2012
23935764Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage.Transl Stroke Res2012
23016931Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1.J Neurochem2012
23118226Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.J Biol Chem2012
22524518Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.BMC Gastroenterol2012
22635103Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice.J Alzheimers Dis2012
22326991APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics.Neurodegener Dis2012
22408624Apolipoprotein mimetic peptides: a new approach for the treatment of asthma.Front Pharmacol2012
21233414Nitric oxide and redox mechanisms in the immune response.J Leukoc Biol2011
22359955[Potential role of presenilin 1 in regulation of synaptic function].Tsitologiia2011
21844565SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target.Blood2011
21893353Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.Trends Pharmacol Sci2011
21297667Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy.Oncogene2011
21289314Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.J Immunol2011
21289177Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.J Neurosci2011
21115487The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis.J Biol Chem2011
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Collaborators

Daniel T Laskowitz
Duke University
Co-authored papers 19
Dale J Christensen
TFF Pharmaceuticals, Inc.
Co-authored papers 13
David S Warner
Duke University Medical Center
Co-authored papers 7
Michael Graham Espey
National Cancer Institute, National Institutes of Health
Co-authored papers 4
John R Lynch
Medical College of Wisconsin
Co-authored papers 4
George Perry
College of Sciences, The University of Texas at San Antonio
Co-authored papers 4
Christine M Hulette
Duke University
Co-authored papers 3
Rosalie C Sears
Oregon Health and Science University
Co-authored papers 3
Raffaella Pippa
University of Navarra, Center for Applied Medical Research (CIMA)
Co-authored papers 3
Ellen R Bennett
Duke University
Co-authored papers 3
Sudhir Sahasrabudhe
University of Medicine and Dentistry of New Jersey, New Jersey Medical School
Co-authored papers 3
Mar??a D Odero
University of Navarra
Co-authored papers 3
Stephen Salloway
Butler Hospital, and Warren Alpert Medical School of Brown University
Co-authored papers 2
Leila K Needham
Co-authored papers 2
Jeffrey W Tyner
Oregon Health & Science University School of Medicine
Co-authored papers 2
Anupriya Agarwal
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Christopher D Lascola
Duke Cancer Institute
Co-authored papers 2
Huaxin Sheng
Duke University Medical Center
Co-authored papers 2
Nameeta P Richard
Randall Children's Hospital at Legacy Emanuel
Co-authored papers 1
Ryan J Mackenzie
Oregon Health & Science University, USA [2] Knight Cancer Institute
Co-authored papers 1
Ronald A Cohen
College of Public Health and Health Professions, University of Florida
Co-authored papers 1
Peter X Shaw
Shiley Eye Institute, University of California San Diego
Co-authored papers 1
Martin E Gleave
University of British Columbia
Co-authored papers 1
Robert D Pearlstein
Duke University Medical Center
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Ladan Fazli
University of British Columbia
Co-authored papers 1
Stephen Correia
RR&D Center for Neurorestoration and Neurotechnology, VA Providence Healthcare System
Co-authored papers 1
Talaignair N Venkatraman
Duke University
Co-authored papers 1
Shawn Mahmood
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
Jeffrey L Goldberg
Spencer Center for Vision Research, Byers Eye Institute, Stanford University
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Release 1.2