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Author Details

Frank McCormick
Frederick National Laboratory for Cancer Research
1975
495
127
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36689660Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.Proc Natl Acad Sci U S A2023
37968881Report From a Multidisciplinary Symposium on the Future of Living Kidney Donor Transplantation.Prog Transplant2023
37450595RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.Sci Adv2023
37149146The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.J Biol Chem2023
37245145RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights.J Invest Dermatol2023
37268708Reduced dynamic complexity allows structure elucidation of an excited state of KRAS<sup>G13D</sup>.Commun Biol2023
34686998NMR <sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation.Biomol NMR Assign2022
35613620ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.Mol Cell2022
35467524Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.Elife2022
35831509Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.Nature2022
35690519Projecting the Economic Impact of Compensating Living Kidney Donors in the United States: Cost-Benefit Analysis Demonstrates Substantial Patient and Societal Gains.Value Health2022
35561303More to the RAS Story: KRAS<sup>G12C</sup> Inhibition, Resistance Mechanisms, and Moving Beyond KRAS<sup>G12C</sup>.Am Soc Clin Oncol Educ Book2022
36144235Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells.Metabolites2022
35904492Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.Cancer Discov2022
36175670Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.Nat Struct Mol Biol2022
35961479Workload for infection prevention and control teams in preventing nosocomial tuberculosis: an underestimated burden.J Hosp Infect2022
35046096RAS at 40: Update from the RAS Initiative.Cancer Discov2022
35101227A brief history of RAS and the RAS Initiative.Adv Cancer Res2022
34983849Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.Proc Natl Acad Sci U S A2022
35091470Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors.Proc Natl Acad Sci U S A2022
35213144Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics.J Am Chem Soc2022
34872108Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models.Blood Adv2022
32822265Evidence-Based Physical Examination for the Diagnosis of Subscapularis Tears: A Systematic Review.Sports Health2021
33541252Promoting Ethical Payment in Human Infection Challenge Studies.Am J Bioeth2021
33846634Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.Nat Genet2021
33870211The Metabolic Landscape of RAS-Driven Cancers from biology to therapy.Nat Cancer2021
33896272Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition.SLAS Discov2021
33837738Correction: DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs.J Biol Chem2021
33749935Estimated impact of novel coronavirus-19 and transplant center inactivity on end-stage renal disease-related patient mortality in the United States.Clin Transplant2021
33689566Plumbing the Depths of Ethical Payment for Research Participation.Am J Bioeth2021
33608534KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.Nat Commun2021
34671754Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling.Cell Rep Methods2021
34380736RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.Proc Natl Acad Sci U S A2021
34514432Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis.Blood Cancer Discov2021
33990767RAS-targeted therapies.Nat Rev Drug Discov2021
33988344Cost Structures of US Organ Procurement Organizations.Transplantation2021
34237269The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression.Curr Biol2021
34307350A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness.Front Cell Dev Biol2021
34330832UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.Proc Natl Acad Sci U S A2021
33271212Reducing the Shortage of Transplant Kidneys: A Lost Opportunity for the US Health Resources and Services Administration (HRSA).Am J Kidney Dis2021
33410398DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs.J Biol Chem2021
32603749Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Kα/δ and HDAC.J Invest Dermatol2021
32341551The duality of human oncoproteins: drivers of cancer and congenital disorders.Nat Rev Cancer2020
33872193SPRED proteins and their roles in signal transduction, development, and malignancy.Genes Dev2020
31667990The cost of procuring deceased donor kidneys: Evidence from OPO cost reports 2013-2017.Am J Transplant2020
31958057Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.Elife2020
31836666Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.J Biol Chem2020
32047043The small molecule BI-2852 induces a nonfunctional dimer of KRAS.Proc Natl Acad Sci U S A2020
31951561Sticking it to KRAS: Covalent Inhibitors Enter the Clinic.Cancer Cell2020
31772119Romidepsin Plus Liposomal Doxorubicin Is Safe and Effective in Patients with Relapsed or Refractory T-Cell Lymphoma: Results of a Phase I Dose-Escalation Study.Clin Cancer Res2020
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Collaborators

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University of California San Francisco
Co-authored papers 9
Oregon Health and Science University
Co-authored papers 7
University of California San Francisco
Co-authored papers 6
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
Frederick National Laboratory for Cancer Research, Inc.
Co-authored papers 5
Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Co-authored papers 4
Co-authored papers 4
Co-authored papers 4
Co-authored papers 4
Brain Tumor Institute, Children's National Hospital
Co-authored papers 4
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 3
Co-authored papers 3
Children's Tumor Foundation
Co-authored papers 3
Co-authored papers 3
University of California san francisco
Co-authored papers 3
Hospital for Sick Children, University of Toronto
Co-authored papers 3
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 3
University Hospitals Cleveland Medical Center and Case Comprehensive Cancer Center
Co-authored papers 3
Co-authored papers 3
Johns Hopkins University
Co-authored papers 3
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 3
University of California los angeles
Co-authored papers 3
College of Life Science, Zhejiang University
Co-authored papers 3
Oregon Health & Science University Hospital.
Co-authored papers 2
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University of California San Francisco
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University of Pennsylvania Perelman School of Medicine.
Co-authored papers 2
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