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Author Details

Alexander K Buell
Institut fur Physikalische Biologie, Heinrich-Heine-Universitat Dusseldorf
2007
93
35
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36939220Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats.MAbs2023
37306611Pyroglutamate-modified amyloid β(3-42) monomer has more β-sheet content than the amyloid β(1-42) monomer.Phys Chem Chem Phys2023
37337111Mass photometric detection and quantification of nanoscale α-synuclein phase separation.Nat Chem2023
37065450Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR.Front Mol Biosci2023
36737754Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains.BMC Biol2023
34991078Cancer cell migration on straight, wavy, loop and grid microfibre patterns.Biofabrication2022
35580288Interaction of Therapeutic d-Peptides with Aβ42 Monomers, Thermodynamics, and Binding Analysis.ACS Chem Neurosci2022
35831316The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.Nat Commun2022
36277637Stability matters, too - the thermodynamics of amyloid fibril formation.Chem Sci2022
34982538A Protein Corona Modulates Interactions of α-Synuclein with Nanoparticles and Alters the Rates of the Microscopic Steps of Amyloid Formation.ACS Nano2022
35314196Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition.J Biol Chem2022
35139467Corrigendum to "Thermodynamics of amyloid fibril formation from non-equilibrium experiments of growth and dissociation" [Biophysical Chemistry 271 (2021) 106549].Biophys Chem2022
33333378β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation.Biophys Chem2021
33881594Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.Eur Biophys J2021
33713996Editorial for the special issue "Protein misfolding and amyloid aggregation" of Biophysical Chemistry.Biophys Chem2021
33831785Microfluidics and the quantification of biomolecular interactions.Curr Opin Struct Biol2021
33578107Thermodynamics of amyloid fibril formation from non-equilibrium experiments of growth and dissociation.Biophys Chem2021
34911929Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation.Nat Commun2021
34570963Hydroxy-Porphyrin as an Effective, Endogenous Molecular Clamp during Early Stages of Amyloid Fibrillization.Chem Asian J2021
34652497Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.Eur Biophys J2021
33937341Secondary Nucleation and the Conservation of Structural Characteristics of Amyloid Fibril Strains.Front Mol Biosci2021
34292722<i>De Novo</i> Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma.Anal Chem2021
33399148Compact fibril-like structure of amyloid β-peptide (1-42) monomers.Chem Commun (Camb)2021
32211238Biochemical and biophysical characterisation of immunoglobulin free light chains derived from an initially unbiased population of patients with light chain disease.PeerJ2020
32069013The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain.ACS Chem Neurosci2020
32365068The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth.PLoS Comput Biol2020
32183378The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of <i>α</i>-Synuclein Amyloid Fibril Formation.Int J Mol Sci2020
30826264α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation.Chem Phys Lipids2019
31790267Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils.J Phys Chem Lett2019
31755512Thermodynamics of amyloid fibril formation from chemical depolymerization.Phys Chem Chem Phys2019
31835741The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG.Biomolecules2019
31713197The Kinetics, Thermodynamics and Mechanisms of Short Aromatic Peptide Self-Assembly.Adv Exp Med Biol2019
31654060The growth of amyloid fibrils: rates and mechanisms.Biochem J2019
31389332An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils.Elife2019
31434882Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy.Nat Commun2019
29313342Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.Anal Chem2018
30061982C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH.Chem Sci2018
29951679Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.Chem Commun (Camb)2018
29893543Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers.ACS Chem Neurosci2018
30271927Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation.Commun Biol2018
29581486Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.Nat Chem2018
28918091Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.J Mol Biol2017
28109328The Nucleation of Protein Aggregates - From Crystals to Amyloid Fibrils.Int Rev Cell Mol Biol2017
28434341Acceleration of α-synuclein aggregation.Amyloid2017
29233218Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.Q Rev Biophys2017
29147538Scaling behaviour and rate-determining steps in filamentous self-assembly.Chem Sci2017
28994295Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.J Am Chem Soc2017
28970886Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways.Chem Sci2017
28673288Nanobodies raised against monomeric É¿-synuclein inhibit fibril formation and destabilize toxic oligomeric species.BMC Biol2017
28640595Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.ACS Chem Neurosci2017
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Collaborators

Christopher M Dobson
University of Cambridge
Co-authored papers 44
Michele Vendruscolo
University of Cambridge
Co-authored papers 13
Dieter Willbold
Institute of Physical Biology, Heinrich Heine University Dusseldorf
Co-authored papers 8
Soumav Nath
Institut fur Physikalische Biologie, Heinrich-Heine-Universitat Dusseldorf
Co-authored papers 4
Gunnar F Schr??der
Institute of Biological Information Processing (Structural Biochemistry)
Co-authored papers 2
Chad A Brautigam
UT Southwestern Medical Center
Co-authored papers 2
David A Weitz
Co-authored papers 2
Julia Chamot-Rooke
Institut Pasteur, Universite Paris Cite, CNRS UAR4
Co-authored papers 2
John Christodoulou
University of Melbourne, The Royal Children's Hospital
Co-authored papers 2
Maike Langini
Institute for Molecular Medicine, Heinrich Heine University
Co-authored papers 1
Sven Diederichs
Medical Center - University of Freiburg, University of Freiburg
Co-authored papers 1
Julie Talbot
Institut Curie, Inserm, CNRS, Universite Paris-Saclay
Co-authored papers 1
Idriss Mahoungou Koumba
and Clinical Immunology, Heinrich Heine University
Co-authored papers 1
Antoine Forget (CM4AI)
University of California San Francisco
Co-authored papers 1
Marcel Kool
Hopp Children's Cancer Center (KiTZ)
Co-authored papers 1
Flavia Bernardi
Institut Curie, PSL Research University, CNRS UMR, INSERM
Co-authored papers 1
Nan Qin
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 1
Gerhard Steger
Institut fur Pysikalische Biologie, Heinrich Heine University Dusseldorf
Co-authored papers 1
Anja Stefanski
Universitatsklinikum
Co-authored papers 1
Marc Remke
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 1
Lena Bl??mel
German Cancer Research Center (DKFZ)
Co-authored papers 1
Anthony E Oro
Stanford University
Co-authored papers 1
Frauke-Dorothee Meyer
German Cancer Research Center (DKFZ)
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Stefan M Pfister
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Vijay Ramaswamy
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Mark A Williams
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Fran??ois Kuonen
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Release 1.2