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Author Details

Paul D Allen
Leeds Institute of Medical Research, University of Leeds
1981
202
60
PMIDPaper TitleJournal TitlePublished Year
37392848Putative malignant hyperthermia mutation Ca<sub>V</sub>1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance.J Biol Chem2023
36541369Expression of Concern: RyR1 and RyR3 isoforms provide distinct intracellular Ca2+ signals in HEK 293 cells.J Cell Sci2022
33301562Molecular Modification of Transient Receptor Potential Canonical 6 Channels Modulates Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia.Anesthesiology2021
33510646Senescence Is Associated With Elevated Intracellular Resting [Ca<sup>2 +</sup>] in Mice Skeletal Muscle Fibers. An <i>in vivo</i> Study.Front Physiol2021
33532996Unravelling the unseen metabolic changes in patients with malignant hyperthermia.Can J Anaesth2021
34705503Ryanodine receptor leak triggers fiber Ca<sup>2+</sup> redistribution to preserve force and elevate basal metabolism in skeletal muscle.Sci Adv2021
34257294A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.Nat Commun2021
32367593Sex-specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia-susceptible mice.FASEB J2020
32665491Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia.Anesthesiology2020
32826313Bioenergetic defects in muscle fibers of <i>RYR1</i> mutant knock-in mice associated with malignant hyperthermia.J Biol Chem2020
32765253Memory and Learning Deficits Are Associated With Ca<sup>2+</sup> Dyshomeostasis in Normal Aging.Front Aging Neurosci2020
32244622TRPCs: Influential Mediators in Skeletal Muscle.Cells2020
30579410Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel.Br J Anaesth2019
30916033Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals.Br J Anaesth2019
30579418Is malignant hyperthermia associated with hyperglycaemia?Br J Anaesth2019
30236258Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1.Br J Anaesth2018
28403410Assessing the pathogenicity of RYR1 variants in malignant hyperthermia.Br J Anaesth2017
25857619Altered ROS production, NF-κB activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells.Biochim Biophys Acta2015
26998172Best Practice BioBanking of Human Heart Tissue.Biophys Rev2015
24662047Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.Mol Cell Biol2014
25181488Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice.PLoS One2014
24847052Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle.J Biol Chem2014
24916688Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability.Stem Cells2014
23148320Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle.J Physiol2013
24349043Nifedipine treatment reduces resting calcium concentration, oxidative and apoptotic gene expression, and improves muscle function in dystrophic mdx mice.PLoS One2013
23159934Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia.FASEB J2013
22131268Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.FASEB J2012
23118233Three-dimensional localization of the α and β subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel.J Biol Chem2012
23071848Blood-based biomarkers of aggressive prostate cancer.PLoS One2012
22768324Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.PLoS One2012
22549782Increased resting intracellular calcium modulates NF-κB-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes.J Biol Chem2012
22547813Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.Proc Natl Acad Sci U S A2012
22411973Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion.Cardiovasc Res2012
22139840Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.J Biol Chem2012
20978128Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice.J Biol Chem2011
22164205Mice null for calsequestrin 1 exhibit deficits in functional performance and sarcoplasmic reticulum calcium handling.PLoS One2011
21788611Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle.J Gen Physiol2011
21511385[Dysfunction of diastolic [Ca²⁺] in cardiomyocytes isolated from chagasic patients].Rev Esp Cardiol2011
21310482Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.Cell Calcium2011
21441923Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.Nat Neurosci2011
21482776Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak.Proc Natl Acad Sci U S A2011
21156754Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.Mol Pharmacol2011
20032806Heart and skeletal muscle are targets of dengue virus infection.Pediatr Infect Dis J2010
20713548Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle.J Gen Physiol2010
20926377Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+.J Biol Chem2010
20937810Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes.J Biol Chem2010
20479110A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR.J Gen Physiol2010
20479108A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels.J Gen Physiol2010
20471964Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1).Biochem Pharmacol2010
20634947Frog alpha- and beta-ryanodine receptors provide distinct intracellular Ca2+ signals in a myogenic cell line.PLoS One2010
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Collaborators

Xandra O Breakefield
Massachusetts General Hospital
Co-authored papers 5
James P Morgan
Co-authored papers 4
Seigo Izumo
Beth Israel Deaconess Medical Center.
Co-authored papers 3
Victor J Dzau
National Academy of Medicine.
Co-authored papers 3
Henry W Querfurth
Tufts Medical Center and Neuroscience, Tufts University
Co-authored papers 2
Michel Komajda
Saint Joseph Hospital, Paris-Sorbonne University
Co-authored papers 2
Hiroshi Takeshima
Co-authored papers 2
Cristobal G Dos Remedios
Victor Chang Cardiac Research Institute
Co-authored papers 2
Norbert H??bner
Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 1
Burkert Pieske
Charite University Medicine, Berlin Institute of Health (BIH)
Co-authored papers 1
Dan L Crimmins
Co-authored papers 1
Kenneth Walsh
University of Virginia School of Medicine
Co-authored papers 1
Steven R Houser
Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University
Co-authored papers 1
David N Louis
Co-authored papers 1
William T Pu
Boston Children's Hospital, Harvard Medical School
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Edward G Lakatta
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Jin Seok Woo
Co-authored papers 1
Hao Zhang
Co-authored papers 1
Richard J Shemin
David Geffen School of Medicine, University of California los angeles
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Todd R Golub
Broad Institute of MIT and Harvard
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Egbert Bisping
Medical University of Graz
Co-authored papers 1
Ronglih Liao
Co-authored papers 1
Michael J Dunn
Co-authored papers 1
Elisabeth R Barton
University of Florida
Co-authored papers 1
Anne Keogh
Co-authored papers 1
Ronald V Lacro
Boston Children's Hospital
Co-authored papers 1
Sadakatsu Ikeda
Tokyo Medical and Dental University Hospital
Co-authored papers 1
Huang-Tian Yang
Co-authored papers 1
Sek Won Kong
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
Co-authored papers 1
Jennifer E Van Eyk
Smidt Heart Institute, Cedars-Sinai Medical Center
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Release 1.2