Author details

Full Name

David E Housman

Affiliation

ORCID

Career Start Year

1970

Papers

369

H Index

111

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35122065	Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis.	Nat Cancer	2021
34179825	FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.	Nat Cancer	2021
33759265	Striatal transcriptome changes linked to drug-induced repetitive behaviors.	European Journal of Neuroscience	2021
34371144	CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.	Neurobiol Dis	2021
32409608	Tenofovir prodrugs potently inhibit Epstein-Barr virus lytic DNA replication by targeting the viral DNA polymerase.	Proceedings of the National Academy of Sciences of the United States of America	2020
31088970	IKKÎ² slows Huntington's disease progression in R6/1 mice.	Proc Natl Acad Sci U S A	2019
31744868	Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.	Proceedings of the National Academy of Sciences of the United States of America	2019
30561649	Transcriptome alterations in myotonic dystrophy skeletal muscle and heart.	Hum Mol Genet	2019
29809168	Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.	Journal of Clinical Investigation	2018
29764981	Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.	EMBO J	2018
29510325	Could antiretrovirals be treating EBV in MS? A case report.	Multiple Sclerosis and Related Disorders	2018
28252579	Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists?	Nursing Research	2017
28887402	Detection of long repeat expansions from PCR-free whole-genome sequence data.	Genome Res	2017
28970536	HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models.	Scientific Reports	2017
28877480	A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) Repeats Associated with Friedreich's Ataxia.	Cell Reports	2017
28514657	Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.	Cell Reports	2017
27601654	Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.	Proc Natl Acad Sci U S A	2016
29263812	A perspective for sequencing familial hypercholesterolaemia in African Americans.	npj Genomic Medicine	2016
27398227	Lead toxicity and genetics in Flint, MI.	npj Genomic Medicine	2016
27647894	Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.	Proc Natl Acad Sci U S A	2016
25385587	Potential function for the Huntingtin protein as a scaffold for selective autophagy.	Proc Natl Acad Sci U S A	2014
25062729	Surveying the landscape of Huntington's disease mechanisms, measurements, and medicines.	Journal of Huntington's disease	2013
24256709	Aberrantly spliced HTT, a new player in Huntington's disease pathogenesis.	RNA Biology	2013
24180290	Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries.	BMC Mol Biol	2013
23872847	Targeting H3K4 trimethylation in Huntington disease.	Proc Natl Acad Sci U S A	2013
23341638	Extensive changes in DNA methylation are associated with expression of mutant huntingtin.	Proceedings of the National Academy of Sciences of the United States of America	2013
23341618	Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.	Proceedings of the National Academy of Sciences of the United States of America	2013
23577159	Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.	PLoS ONE	2013
23577104	Systematic identification of combinatorial drivers and targets in cancer cell lines.	PLoS One	2013
23365139	Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.	Proc Natl Acad Sci U S A	2013
25062730	In vivo identification of therapeutic constructs from pooled candidates in HD model mice.	Journal of Huntington's disease	2013
22020333	Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.	Oncogene	2012
22300544	Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.	Journal of the American Chemical Society	2012
22541556	Reduced expression of ribosomal proteins relieves microRNA-mediated repression.	Molecular Cell	2012
22529362	Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice.	Proceedings of the National Academy of Sciences of the United States of America	2012
22901804	Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.	Cell	2012
21987724	Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.	Cancer Res	2011
21315254	Huntington's disease: can mice lead the way to treatment?	Neuron	2011
20147317	CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.	Hum Mol Genet	2010
21034477	Rapid haplotype inference for nuclear families.		2010
20098615	Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.	PLoS ONE	2010
18712713	Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.	Am J Med Genet B Neuropsychiatr Genet	2009
19050450	The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort.	J Hypertens	2009
19492395	Development of a method for the high-throughput quantification of cellular proteins.	ChemBioChem	2009
19664996	Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease.	Anal Biochem	2009
19196966	Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.	Proceedings of the National Academy of Sciences of the United States of America	2009
19276365	Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas.	Cancer Research	2009
19194457	Association between arterial stiffness and variations in oestrogen-related genes.	J Hum Hypertens	2009
18481795	Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.	Genet Epidemiol	2008
18974345	Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.	Science	2008