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Author Details

Evripidis Gavathiotis
Albert Einstein College of Medicine
2000
59
36
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36496299Mitochondrial dynamics proteins as emerging drug targets.Trends Pharmacol Sci2023
38051103Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.Cancer Res Commun2023
37821702Apoptotic stress causes mtDNA release during senescence and drives the SASP.Nature2023
37100955Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell Death Differ2023
36383673Chaperone-mediated autophagy regulates adipocyte differentiation.Sci Adv2022
35864098Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.Nat Commun2022
33442062Chaperone-mediated autophagy sustains haematopoietic stem-cell function.Nature2021
33602934Eltrombopag directly inhibits BAX and prevents cell death.Nat Commun2021
33891876Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell2021
34110247Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis.Autophagy2021
32421206In Response to Regarding: Apoptosis Signaling Molecules as Treatment Targets in Head and Neck Squamous Carcinoma.Laryngoscope2020
31894587Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma.Laryngoscope2020
31048321Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment.Cancer Discov2019
29677443ICBS 2017 in Shanghai-Illuminating Life with Chemical Innovation.ACS Chem Biol2018
29674596MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.Science2018
29362479Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.Cell Death Differ2018
29492188Pulling the BAX trigger for tumor cell death.Oncotarget2018
29461827Current Insights of BRAF Inhibitors in Cancer.J Med Chem2018
28735187Progress in targeting the BCL-2 family of proteins.Curr Opin Chem Biol2017
28465352Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.J Biol Chem2017
29083320Pharmacological inhibition of the transcription factor PU.1 in leukemia.J Clin Invest2017
28984291New perspectives for targeting RAF kinase in human cancer.Nat Rev Cancer2017
29017059Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.Cancer Cell2017
28801102Editorial overview: Chemical genetics and epigenetics.Curr Opin Chem Biol2017
26799652Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy2016
26565029Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.J Biol Chem2016
27768876An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.Mol Cell2016
27702998Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.J Biol Chem2016
27626173Self-regulation of BAX-induced cell death.Oncotarget2016
27775718Correcting mitochondrial fusion by manipulating mitofusin conformations.Nature2016
27622340An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.Cancer Cell2016
27425408An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.Mol Cell2016
27523909An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.Cancer Cell2016
27315536Chemical genetics: Unraveling cell death mysteries.Nat Chem Biol2016
25437618Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.Eur J Med Chem2015
26344567An interconnected hierarchical model of cell death regulation by the BCL-2 family.Nat Cell Biol2015
25684204Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Mol Cell2015
24358963Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.ACS Chem Biol2014
25049413Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.Proc Natl Acad Sci U S A2014
25076060Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.Mar Drugs2014
23584676Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives.Nat Chem Biol2013
23890007Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3.Chem Biol2013
22622039A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.J Clin Invest2012
22999885A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.Chem Biol2012
22493254Bax regulates primary necrosis through mitochondrial dynamics.Proc Natl Acad Sci U S A2012
22634637Direct and selective small-molecule activation of proapoptotic BAX.Nat Chem Biol2012
21325897Tracking BAX once its trigger is pulled.Cell Cycle2011
21978892BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.Trends Biochem Sci2011
20660316Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.Proc Natl Acad Sci U S A2010
21070973BH3-triggered structural reorganization drives the activation of proapoptotic BAX.Mol Cell2010
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Collaborators

Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 8
Richard N Kitsis
Co-authored papers 5
Qisheng Xin
Albert Einstein College of Medicine
Co-authored papers 5
Gerald W Dorn
Co-authored papers 4
Susmita Kaushik
Albert Einstein College of Medicine
Co-authored papers 4
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 3
Ted M Dawson
Johns Hopkins University School of Medicine
Co-authored papers 3
Antonio Diaz
Albert Einstein College of Medicine, USA Institute for Aging Studies
Co-authored papers 3
Brent R Stockwell
Columbia University
Co-authored papers 3
Inmaculada Tasset
Albert Einstein College of Medicine
Co-authored papers 3
Valina L Dawson
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Co-authored papers 3
Jan Paul Medema
Oncode Institute
Co-authored papers 3
Stuart A Lipton
The Scripps Research Institute, University of California
Co-authored papers 2
Mathieu Bourdenx
University College London, UK Dementia Research Institute
Co-authored papers 2
Michael Karin
Co-authored papers 2
Yves R Juste
Albert Einstein College of Medicine
Co-authored papers 2
Milton H Werner
Inhibikase Therapeutics Inc.
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Jerry E Chipuk
Co-authored papers 2
Rosario Rizzuto
Co-authored papers 2
Peter D Adams
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Meenhard Herlyn
Ellen and Ronald Caplan Cancer Center, The Wistar Institute
Co-authored papers 2
Simone Fulda
Co-authored papers 2
Brian D Dynlacht
New York University Cancer Institute, New York University School of Medicine
Co-authored papers 2
Nicola Di Daniele
University of Rome Tor Vergata
Co-authored papers 2
Laura Santambrogio
Weill Cornell School of Medicine
Co-authored papers 2
Vladimir N Malashkevich
Albert Einstein College of Medicine
Co-authored papers 2
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 2
Ian G Mills
Queen's University Belfast
Co-authored papers 1
Il??ana Antony-Debr??
INSERM, France Villejuif Universite Paris-Saclay
Co-authored papers 1
Hirotaka Watada
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Release 1.2