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Author Details

Kalappa Muniyappa
Indian Institute of Science
1979
142
33
PMIDPaper TitleJournal TitlePublished Year
36455103Design and Synthesis of Xanthone Analogues Conjugated with Aza-aromatic Substituents as Promising G-Quadruplex Stabilizing Ligands and their Selective Cancer Cell Cytotoxic Action.Chembiochem2023
37649278SUMOylation of yeast Pso2 enhances its translocation and accumulation in the mitochondria and suppresses methyl methanesulfonate-induced mitochondrial DNA damage.Mol Microbiol2023
37082748New Xanthone Derivatives as Potent G-Quadruplex Binders for Developing Anti-Cancer Therapeutics.ACS Pharmacol Transl Sci2023
36459831Macrophage activation highlight an important role for NER proteins in the survival, latency and multiplication of Mycobacterium tuberculosis.Tuberculosis (Edinb)2023
36161519Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G-Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity.ChemMedChem2022
35810330Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function.Biophys J2022
35482533Dual targeting of Saccharomyces cerevisiae Pso2 to mitochondria and the nucleus, and its functional relevance in the repair of DNA interstrand crosslinks.G3 (Bethesda)2022
32602194The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function.FEBS J2021
33933468Novel insights into ATP-Stimulated Cleavage of branched DNA and RNA Substrates through Structure-Guided Studies of the Holliday Junction Resolvase RuvX.J Mol Biol2021
32289341Genome-wide analysis reveals a regulatory role for G-quadruplexes during Adenovirus multiplication.Virus Res2020
35685402Targeting G-quadruplex DNA with synthetic dendritic peptide: modulation of the proliferation of human cancer cells.RSC Adv2020
32001794Identification and characterization of two conserved G-quadruplex forming motifs in the Nipah virus genome and their interaction with G-quadruplex specific ligands.Sci Rep2020
31923481Deciphering the essentiality and function of SxSx motif in Mycobacterium tuberculosis UvrB.Biochimie2020
31705809UvrA and UvrC subunits of the Mycobacterium tuberculosis UvrABC excinuclease interact independently of UvrB and DNA.FEBS Lett2020
33216839Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11-Rad50-Nbs1 complex in the repair of cisplatin-induced DNA cross-links.Oncotarget2020
32526474The extended N-terminus of Mycobacterium smegmatis RecX potentiates its ability to antagonize RecA functions.Biochim Biophys Acta Proteins Proteom2020
32302880Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity.Eur J Med Chem2020
30325243TRPV4 activation in rat carotid artery in DOCA hypertension involves eNOS and endothelium-derived contractile factor (EDCF).Clin Exp Hypertens2019
31358794Elucidating the functional role of Mycobacterium smegmatis recX in stress response.Sci Rep2019
30726069The Anionic Phospholipids in the Plasma Membrane Play an Important Role in Regulating the Biochemical Properties and Biological Functions of RecA Proteins.Biochemistry2019
29459277Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazoleâ¿¿carbazole ligands.Eur J Med Chem2018
29873124The second messenger cyclic di-AMP negatively regulates the expression of Mycobacterium smegmatis recA and attenuates DNA strand exchange through binding to the C-terminal motif of mycobacterial RecA proteins.Mol Microbiol2018
29632232Correction for Sharadamma et al., "Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination".J Bacteriol2018
29485247Structural Characterization of i-Motif Structure in the Human Acetyl-CoA Carboxylaseâ¿¿1 Gene Promoters and Their Role in the Regulation of Gene Expression.Chembiochem2018
28642366<i>Saccharomyces cerevisiae</i> Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA.J Biol Chem2017
28165710Enhanced G-Quadruplex DNA Stabilization and Telomerase Inhibition by Novel Fluorescein Derived Salen and Salphen Based Ni(II) and Pd(II) Complexes.Bioconjug Chem2017
28538144Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.Biophys J2017
28910739Novel ruthenium azo-quinoline complexes with enhanced photonuclease activity in human cancer cells.Eur J Med Chem2017
28696279Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination.J Bacteriol2017
26817626Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain.Mol Microbiol2016
27618337Mycobacterium tuberculosis UvrB Is a Robust DNA-Stimulated ATPase That Also Possesses Structure-Specific ATP-Dependent DNA Helicase Activity.Biochemistry2016
27604686Novel Oligopyrrole Carboxamide based Nickel(II) and Palladium(II) Salens, Their Targeting of Human G-Quadruplex DNA, and Selective Cancer Cell Toxicity.Chem Asian J2016
27966484Genetic and biochemical evidences reveal novel insights into the mechanism underlying <i>Saccharomyces cerevisiae</i> Sae2-mediated abrogation of DNA replication stress.J Biosci2016
26915388Molecular Mechanism Underlying ATP-Induced Conformational Changes in the Nucleoprotein Filament of Mycobacterium smegmatis RecA.Biochemistry2016
27058681Discovery and Structural Characterization of G-quadruplex DNA in Human Acetyl-CoA Carboxylase Gene Promoters: Its Role in Transcriptional Regulation and as a Therapeutic Target for Human Disease.J Med Chem2016
25740138Structural studies on Mycobacterium tuberculosis RecA: molecular plasticity and interspecies variability.J Biosci2015
26276393Mycobacterium tuberculosis RecG protein but not RuvAB or RecA protein is efficient at remodeling the stalled replication forks: implications for multiple mechanisms of replication restart in mycobacteria.J Biol Chem2015
26149178New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer.Org Biomol Chem2015
26067376Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction.Biochemistry2015
25973364Functional roles of N-terminal and C-terminal domains in the overall activity of a novel single-stranded DNA binding protein of Deinococcus radiodurans.FEBS Open Bio2015
25802334Molecular and Functional Characterization of RecD, a Novel Member of the SF1 Family of Helicases, from Mycobacterium tuberculosis.J Biol Chem2015
24067899RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.Carcinogenesis2014
25294832Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis.Nucleic Acids Res2014
25324543Molecular dissection of Mycobacterium tuberculosis integration host factor reveals novel insights into the mode of DNA binding and nucleoid compaction.J Biol Chem2014
25062468Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells.J Med Chem2014
24814187The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins, has unanticipated diverse functions.Gene2014
24722837Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery.J Antimicrob Chemother2014
23221642Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein.Nucleic Acids Res2013
23825559Dynamics and Regulation of RecA Polymerization and De-Polymerization on Double-Stranded DNA.PLoS One2013
23841450N-terminal disordered domain of Saccharomyces cerevisiae Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation.Biochemistry2013
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Collaborators

NYU Langone Medical Center
Co-authored papers 6
Sloan Kettering Institute
Co-authored papers 3
Indian Institute of Science Education and Research Pune
Co-authored papers 1
Indian Institute of Technology Gandhinagar
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Los Alamos National Laboratory
Co-authored papers 1
Los Alamos National Laboratory
Co-authored papers 1
Banaras Hindu University
Co-authored papers 1
Indian Institute of Science Education and Research (IISER)
Co-authored papers 1
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Co-authored papers 1
Los Alamos National Laboratory
Co-authored papers 1
Los Alamos National Laboratory
Co-authored papers 1