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| 21660661 | Cruzain : the path from target validation to the clinic. | Adv Exp Med Biol | 2011 |
| 20088534 | Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. | J Med Chem | 2010 |
| 20856868 | In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. | PLoS Negl Trop Dis | 2010 |
| 20544024 | Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei. | PLoS Negl Trop Dis | 2010 |
| 20378535 | A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. | J Biol Chem | 2010 |
| 19128015 | Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. | J Med Chem | 2009 |
| 19620707 | Vinyl sulfones as antiparasitic agents and a structural basis for drug design. | J Biol Chem | 2009 |
| 19753483 | Two approaches to discovering and developing new drugs for Chagas disease. | Mem Inst Oswaldo Cruz | 2009 |
| 19773167 | Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. | Bioorg Med Chem Lett | 2009 |
| 19111576 | The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. | Mol Biochem Parasitol | 2009 |
| 18160404 | Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. | J Biol Chem | 2008 |
| 17502099 | The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. | Structure | 2007 |
| 17503785 | Stability for function trade-offs in the enolase superfamily "catalytic module". | Biochemistry | 2007 |
| 17403677 | The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal. | J Biol Chem | 2007 |
| 16864794 | Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. | Proc Natl Acad Sci U S A | 2006 |
| 15727867 | Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. | Bioorg Med Chem | 2005 |
| 15162496 | Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution. | Proteins | 2004 |
| 15229895 | Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution. | Proteins | 2004 |
| 15229893 | Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution. | Proteins | 2004 |
| 15229894 | Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution. | Proteins | 2004 |
| 15229892 | Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold. | Proteins | 2004 |
| 15211526 | Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. | Proteins | 2004 |
| 15211524 | Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution. | Proteins | 2004 |
| 15211523 | Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution. | Proteins | 2004 |
| 15211522 | Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution. | Proteins | 2004 |
| 15326606 | Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution. | Proteins | 2004 |
| 14705036 | Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution. | Proteins | 2004 |
| 14705032 | Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution. | Proteins | 2004 |
| 14997577 | Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution. | Proteins | 2004 |
| 14997579 | Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution. | Proteins | 2004 |
| 14997578 | Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution. | Proteins | 2004 |
| 15048837 | Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution. | Proteins | 2004 |
| 15146505 | Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution. | Proteins | 2004 |
| 15103640 | Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution. | Proteins | 2004 |
| 15103638 | Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution. | Proteins | 2004 |
| 15162497 | Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution. | Proteins | 2004 |
| 12467703 | Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain. | Bioorg Med Chem | 2003 |
| 12945057 | Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution. | Proteins | 2003 |
| 14604516 | Can mosquitoes be bitten? A new hope for anti-malarial drug design. | Structure | 2003 |
| 12834348 | The extended interactions and Gla domain of blood coagulation factor Xa. | Biochemistry | 2003 |
| 12486729 | Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. | Proteins | 2003 |
| 11755183 | Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. | Mol Biochem Parasitol | 2002 |
| 12193646 | Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. | Proc Natl Acad Sci U S A | 2002 |
| 12211025 | Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. | Proteins | 2002 |
| 12000756 | The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. | J Biol Chem | 2002 |
| 11388810 | Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. | Protein Expr Purif | 2001 |
| 11704274 | Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. | Mol Biochem Parasitol | 2001 |
| 11070225 | Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. | Arch Med Res | 2000 |
| 10997902 | A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. | Structure | 2000 |
| 10347181 | Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. | J Biol Chem | 1999 |