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Author Details

Angela Cacace
O.W.) and University of Rochester Medical Center
1991
35
22
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36372569Fragile X Syndrome Patient-Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes.Biol Psychiatry2023
34581500Current directions in tau research: Highlights from Tau 2020.Alzheimers Dement2022
35166597Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.Nucleic Acid Ther2022
32576599p38<i>α</i> Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy.J Pharmacol Exp Ther2020
31880363Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons.Eur J Neurosci2020
32092825Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.Mol Ther Nucleic Acids2020
29456084Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.Cell2018
29806693Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.J Neurochem2018
28395743Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line.Stem Cell Res2017
25560755Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder.Mol Psychiatry2015
26109678Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.J Pharmacol Exp Ther2015
25933020Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.PLoS One2015
25690789Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.Bioorg Med Chem Lett2015
25754495The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.Bioorg Med Chem Lett2015
24637750The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.Acta Crystallogr F Struct Biol Commun2014
25153994Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.PLoS One2014
23368907Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.J Med Chem2013
23809366Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease.Alzheimers Dement2013
22024716The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex.Neurobiol Dis2012
18566482Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening.J Biomol Screen2008
17259590Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay.J Biomol Screen2007
17272827A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.J Biomol Screen2007
12946641An ultra-HTS process for the identification of small molecule modulators of orphan G-protein-coupled receptors.Drug Discov Today2003
10891492Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling.Mol Cell Biol2000
9858547Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.Mol Cell Biol1999
9572476Overexpression of PKCepsilon in R6 fibroblasts causes increased production of active TGFbeta.J Cell Physiol1998
9371754KSR stimulates Raf-1 activity in a kinase-independent manner.Proc Natl Acad Sci U S A1997
9000126PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.Oncogene1996
7586146Altered expression of cyclins and c-fos in R6 cells that overproduce PKC epsilon.Carcinogenesis1995
9815893Effects of suramin-related and other clinically therapeutic polyanions on protein kinase C activity.Clin Cancer Res1995
7898937Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth.Oncogene1995
7767974Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression.Carcinogenesis1995
8247550Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.Oncogene1993
8336936The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.Oncogene1993
1887896Fatty acids stereospecifically stimulate neurotensin release and increase [Ca2+]i in enteric endocrine cells.Am J Physiol1991
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Collaborators

Hartford Hospital Research Program, Hartford Hospital
Co-authored papers 4
Center for Cancer Research, National Cancer Institute-Frederick
Co-authored papers 3
Whitehead Institute for Biomedical Research
Co-authored papers 2
The University of Florida
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Massachusetts General Hospital
Co-authored papers 2
Gladstone Institute of Neurological Disease
Co-authored papers 2
Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
Co-authored papers 1
National Institute of Neurological Disorders and Stroke
Co-authored papers 1
University of Texas Health Science Center San Antonio
Co-authored papers 1
New York University.
Co-authored papers 1
Massachusetts General Hospital/Harvard Medical School
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Harvard Medical School and McLean Hospital
Co-authored papers 1
University of Kentucky
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 1
Kerwin Research Center and Memory Care Dallas Texas USA.
Co-authored papers 1
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University of Virginia
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
Eisai Inc.
Co-authored papers 1
Queen Square Institute of Neurology, University College London
Co-authored papers 1