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Author Details

Shawn S-C Li
University of Western Ontario
2002
68
29
PMIDPaper TitleJournal TitlePublished Year
36442320Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification.EBioMedicine2022
34081630Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.JCI Insight2021
34480897Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors.J Biol Chem2021
34235498Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies.Cell Rep Methods2021
32668242Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome.Cell Rep2020
32643287MMS2plot: An R Package for Visualizing Multiple MS/MS Spectra for Groups of Modified and Non-Modified Peptides.Proteomics2020
30431205Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis.Protein Sci2019
31484049Single-Layer β Sheets as Versatile Protein-Binding Modules.Structure2019
29217616Interactome Mapping Uncovers a General Role for Numb in Protein Kinase Regulation.Mol Cell Proteomics2018
30205513Phosphorylation-Dependent Inhibition of Akt1.Genes (Basel)2018
30091902Reverse Binding Mode of Phosphotyrosine Peptides with SH2 Protein.Biochemistry2018
30395435Affinity Purification of Methyllysine Proteome by Site-Specific Covalent Conjugation.Anal Chem2018
30469473The Transcriptional Repressor BS69 is a Conserved Target of the E1A Proteins from Several Human Adenovirus Species.Viruses2018
30382091Identification and characterization of a large family of superbinding bacterial SH2 domains.Nat Commun2018
29773654Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.J Biol Chem2018
29037858Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay.Am J Pathol2018
27880036Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS.Proteomics2017
28192900Biphasic Affinity Chromatographic Approach for Deep Tyrosine Phosphoproteome Analysis.Anal Chem2017
28092048Using Reciprocal Protein-Peptide Array Screening to Unravel Protein Interaction Networks.Methods Mol Biol2017
28092036Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain.Methods Mol Biol2017
28092028SH2 Ligand Prediction-Guidance for In-Silico Screening.Methods Mol Biol2017
29220647SnapShot: Lysine Methylation beyond Histones.Mol Cell2017
27440912Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands.Mol Cell Proteomics2016
27642862Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.Nat Chem Biol2016
25491103Non-histone protein methylation as a regulator of cellular signalling and function.Nat Rev Mol Cell Biol2015
26166433A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.Nat Commun2015
25776560Cell regulation by phosphotyrosine-targeted ubiquitin ligases.Mol Cell Biol2015
25449829Systematic investigation of hierarchical phosphorylation by protein kinase CK2.J Proteomics2015
24410844Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation.Cell Commun Signal2014
25381250Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.J Biol Chem2014
24556848An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation.Mol Cell Proteomics2014
23313216Systematic characterization of the specificity of the SH2 domains of cytoplasmic tyrosine kinases.J Proteomics2013
23452850Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.Cell2013
21947442Reactive oxygen species and the neuronal fate.Cell Mol Life Sci2012
23012655Superbinder SH2 domains act as antagonists of cell signaling.Sci Signal2012
23134684Phosphotyrosine recognition domains: the typical, the atypical and the versatile.Cell Commun Signal2012
21227701Evolving specificity from variability for protein interaction domains.Trends Biochem Sci2011
21558555A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling.Sci Signal2011
21397687Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration.Biochim Biophys Acta2011
19322654NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics.Breast Cancer Res Treat2010
20836566Systematic identification of methyllysine-driven interactions for histone and nonhistone targets.J Proteome Res2010
20567495NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response.Int J Biol Sci2010
20188166Insulin-like growth factor binding protein-6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to regulate cell fate.Cell Signal2010
20233719Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.J Biol Chem2010
20168079Numb: A new player in EMT.Cell Adh Migr2010
19900592Regulation of cell proliferation and survival: convergence of protein kinases and caspases.Biochim Biophys Acta2010
19150402SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux.Cell Signal2009
19649594CelluSpots: a reproducible means of making peptide arrays for the determination of SH2 domain binding specificity.Methods Mol Biol2009
19649589Using peptide array to identify binding motifs and interaction networks for modular domains.Methods Mol Biol2009
18042676The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin-like fold.Protein Sci2008
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Collaborators

Tony Pawson
Co-authored papers 6
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 6
Elena Evdokimova
University of Toronto
Co-authored papers 3
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 3
Adelinda Yee
University of Toronto
Co-authored papers 3
William L Stanford
Ottawa Hospital Research Institute
Co-authored papers 2
Jiefei Tong
Hospital for Sick Children
Co-authored papers 2
Michael F Moran
Hospital for Sick Children, University of Toronto
Co-authored papers 2
Joe S Mymryk
University of Western Ontario
Co-authored papers 2
Suzanne Ackloo
University of Toronto
Co-authored papers 2
Alexei Savchenko
University of Toronto
Co-authored papers 1
Tito Poli
University Hospital of Parma
Co-authored papers 1
Ruud H Brakenhoff
Vrije Universiteit Amsterdam
Co-authored papers 1
Charles R Leemans
Location Vrije Universiteit Amsterdam
Co-authored papers 1
Xinyi Liu
The University of Illinois at Chicago
Co-authored papers 1
Michael P Hier
Jewish General Hospital, McGill University
Co-authored papers 1
Kevin R Brown
College Street, University of Toronto
Co-authored papers 1
Frank J P Hoebers
Maastricht University Medical Centre
Co-authored papers 1
Ari Elson
The Weizmann Institute of Science
Co-authored papers 1
Francisco Laxague
Schulich School of Medicine & Dentistry, Western University
Co-authored papers 1
Eitan Prisman
University of British Columbia
Co-authored papers 1
Catherine F Poh
University of British Columbia
Co-authored papers 1
Sarah E B Ryan
University of Western Ontario
Co-authored papers 1
Mushfiq H Shaikh
University of Western Ontario
Co-authored papers 1
Christopher J Howlett
Western University
Co-authored papers 1
Julie D Forman-Kay
Hospital for Sick Children
Co-authored papers 1
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
Mara S Serafini
Fondazione IRCCS Istituto Nazionale dei Tumouri
Co-authored papers 1
Kathrin Scheckenbach
Heinrich-Heine University
Co-authored papers 1
Steven F Gameiro
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