Author details

Full Name

Gen-Sheng Feng

Affiliation

ORCID

Career Start Year

1988

Papers

204

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36801205	Osr1 Is a Critical Regulator of Macrophage Polarization in NASHÂ Progression.		2023
35503714	Pharmaceutical SH2 domain-containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity.	Hepatology	2023
37846866	Identification of CD133 intercellsomes in intercellular communication to offset intracellular signal deficit.		2023
36828281	Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages.	Cell Mol Gastroenterol Hepatol	2023
34810213	Concurrent Disruption of the Ras/MAPK and NF-ÎºB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis.	Molecular Cancer Research	2022
36002018	Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling.	Journal of Molecular Cell Biology	2022
34860431	Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice.	Hepatology	2022
35025868	Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy.	PLoS Genetics	2022
35134346	Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics.	Developmental Cell	2022
34758313	Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.	Cell Reports	2021
33637697	Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice.	Cell Death and Disease	2021
34233845	Androgen receptor, neovascularization and liver cancer metastasis.	Journal of Hepatology	2021
32715491	Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies.	Hepatology	2021
34764263	Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis.	Nature Communications	2021
31210146	The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis.		2020
33615152	Human-specific polymorphic pseudogenization of <i>SIGLEC12</i> protects against advanced cancer progression.	FASEB Bioadv	2020
32546483	Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.	Journal of Biological Chemistry	2020
30716082	Lens differentiation is controlled by the balance between PDGF and FGF signaling.	PLoS Biol	2019
31843886	A tumorigenic index for quantitative analysis of liver cancer initiation and progression.	Proceedings of the National Academy of Sciences of the United States of America	2019
30520052	Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury.	Hepatology	2019
30622311	High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice.	International Journal of Obesity	2019
31090263	Tumor immunology and immunotherapy: a journey I started from Hangzhou.		2019
30693544	An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice.	Hepatology	2019
31216480	TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.	Cell Rep	2019
31208945	Stress Conditions Induced by Locoregional Therapies Stimulate Enrichment and Proliferation of Liver Cancer Stem Cells.	Journal of Vascular and Interventional Radiology	2019
29360039	Crk proteins transduce FGF signaling to promote lens fiber cell elongation.	Elife	2018
29505847	Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic Î²-Catenin, PIK3CA and MET.	Journal of Hepatology	2018
29152756	Î²-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic Î²-catenin and MET.	Hepatology	2018
27935860	T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.	Oncotarget	2017
28424251	Nuclear Shp2 directs normal embryo implantation via facilitating the ERÎ± tyrosine phosphorylation by the Src kinase.	Proc Natl Acad Sci U S A	2017
28842424	Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.	FASEB Journal	2017
28660979	Gel-seq: whole-genome and transcriptome sequencing by simultaneous low-input DNA and RNA library preparation using semi-permeable hydrogel barriers.	Lab Chip	2017
29028795	Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.	PLoS Genet	2017
29141219	Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.	Cell Rep	2017
29255148	Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.	Nature Communications	2017
27662665	Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China.	Oncotarget	2017
27582544	SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.	Oncotarget	2016
25905985	PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression.		2016
27100271	SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis.	Journal of Cellular Physiology	2016
27282405	Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease.	Journal of Molecular Cell Biology	2016
27275015	Abnormal <i>PTPN11</i> enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.	JCI Insight	2016
26826310	Treating leukemia at the risk of inducing severe anemia.	Exp Hematol	2016
26858399	Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting.	Proc Natl Acad Sci U S A	2016
27799550	Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.	Proceedings of the National Academy of Sciences of the United States of America	2016
27974211	Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.	Cell Rep	2016
26460004	Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.	Proc Natl Acad Sci U S A	2015
25500873	Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis.	Acta Pharmacologica Sinica	2015
25919282	SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice.	Journal of Bone and Mineral Research	2015
25915733	Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.	Nat Immunol	2015
25538234	Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst.	Journal of Biological Chemistry	2015