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Author Details

Mitchell J Frederick
Baylor College of Medicine
1995
73
33
PMIDPaper TitleJournal TitlePublished Year
36689560Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma.Clin Cancer Res2023
37012319Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.Br J Cancer2023
37307602Machine learning driven index of tumor multinucleation correlates with survival and suppressed anti-tumor immunity in head and neck squamous cell carcinoma patients.Oral Oncol2023
35301263A general calculus of fitness landscapes finds genes under selection in cancers.Genome Res2022
36002187Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response.J Immunother Cancer2022
35972731Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.Clin Cancer Res2022
36169922Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma.Cancer Res2022
36124629Inhibition of the Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib in Loss-of-Function NOTCH1-Mutant Head and Neck Cancer.Oncologist2022
35184149Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration.Mod Pathol2022
32073931Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.Int J Radiat Biol2021
34732714Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.Nat Commun2021
34455983Biology of the Radio- and Chemo-Responsiveness in HPV Malignancies.Semin Radiat Oncol2021
33947685Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress.Mol Cancer Ther2021
32286489High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung.Sci Rep2020
31648864Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting.Oral Oncol2020
33322834NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma.Cells2020
30626753Variations in HPV function are associated with survival in squamous cell carcinoma.JCI Insight2019
30770351PDK1 Mediates <i>NOTCH1</i>-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition.Clin Cancer Res2019
29229598<i>CDKN2A/p16</i> Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition.Cancer Res2018
29625050Oncogenic Signaling Pathways in The Cancer Genome Atlas.Cell2018
28790110Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk <i>TP53</i> Mutation.Clin Cancer Res2017
28126323Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.Cancer Lett2017
29156801Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.Oncotarget2017
27574101Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.Nat Commun2016
25504633Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.Mol Cancer Ther2015
26342026New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development.Cancer Prev Res (Phila)2015
26124202Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.Clin Cancer Res2015
25892230Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy.Cell Rep2015
25634208Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.Cancer Res2015
25691460Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients.Cancer Res2015
23729178Src inhibitors in suppression of papillary thyroid carcinoma growth.Head Neck2014
25303977Mutational landscape of aggressive cutaneous squamous cell carcinoma.Clin Cancer Res2014
24786473Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.Epigenetics2014
24874835Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers.Clin Cancer Res2014
24123531HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells.Head Neck2014
22907887Lessons learned from next-generation sequencing in head and neck cancer.Head Neck2013
23839309Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53.Mol Cancer Ther2013
23619168Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.Cancer Discov2013
23764725CT imaging correlates of genomic expression for oral cavity squamous cell carcinoma.AJNR Am J Neuroradiol2013
23436414Reverse phase protein microarrays and their utility in drug development.Methods Mol Biol2013
23032744Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma.Clin Cancer Res2012
20629091Targeted molecular therapy of head and neck squamous cell carcinoma with the tyrosine kinase inhibitor vandetanib in a mouse model.Head Neck2011
21798897Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.Science2011
21692052Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.Cancer2011
21220477Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model.Clin Cancer Res2011
21281788Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.Am J Pathol2011
20587665MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo.Mol Cancer Ther2010
19218429CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth.Proc Natl Acad Sci U S A2009
19109182Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections.J Immunol2009
18004979LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation.DNA Cell Biol2008
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Collaborators

Jeffrey N Myers
The University of Texas MD Anderson Cancer Center
Co-authored papers 33
Adel K El-Naggar
MD Anderson Cancer Center
Co-authored papers 16
David A Wheeler
Baylor College of Medicine
Co-authored papers 6
Olivier Lichtarge
Baylor College of Medicine
Co-authored papers 5
Stephen Y Lai
The University of Texas MD Anderson Cancer Center
Co-authored papers 5
Richard A Gibbs
Baylor College of Medicine
Co-authored papers 4
Andrew G Sikora
Co-authored papers 4
Timothy P Heffernan
Co-authored papers 3
Chenfei Huang
Celularity Inc.
Co-authored papers 3
John N Weinstein
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
Gary A Silverman
Washington University School of Medicine
Co-authored papers 3
Donna M Muzny
Baylor College of Medicine
Co-authored papers 3
Joseph A Califano
University of California
Co-authored papers 3
Steven H Lin
University of Texas MD Anderson Cancer Center
Co-authored papers 2
Min Gao
College of Horticulture, China Agricultural University
Co-authored papers 2
Emanuel F Petricoin
Center for Applied Proteomics and Molecular Medicine, George Mason University
Co-authored papers 2
Scott M Lippman
Moores Cancer Center, university of california san diego
Co-authored papers 2
Kyle R Covington
Baylor College of Medicine
Co-authored papers 2
Wayne M Koch
Johns Hopkins University School of Medicine
Co-authored papers 2
Stephanie C Hicks
Johns Hopkins Bloomberg School of Public Health
Co-authored papers 2
William H Westra
Icahn School of Medicine at Mount Sinai Hospital.
Co-authored papers 2
Chetan Bettegowda
Co-authored papers 2
Jean-Pierre J Issa
Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine
Co-authored papers 2
Beth M Beadle
Stanford University
Co-authored papers 2
Sahil Seth
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Ryan Li
Oregon Health & Science University
Co-authored papers 2
Victor E Velculescu
Co-authored papers 2
Matthew Meyerson
Broad Institute
Co-authored papers 1
Alexander J Lazar
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Theresa Guo
Moores Cancer Center, University of California
Co-authored papers 1
Release 1.2