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Author Details

Heng Xu
National Cancer Institute, National Institutes of Health
1986
86
29
PMIDPaper TitleJournal TitlePublished Year
2301695214-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.J Med Chem2012
19953652Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.Synapse2010
21039196Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models.Nanomedicine (Lond)2010
21036244In vitro and in vivo assessment of mu opioid receptor constitutive activity.Methods Enzymol2010
19505829Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging.Bioorg Med Chem2009
19423001Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH.Nucl Med Biol2009
19555072A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives.Bioconjug Chem2009
18359632A novel bifunctional maleimido CHX-A'' chelator for conjugation to thiol-containing biomolecules.Bioorg Med Chem Lett2008
18472184Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors.Peptides2008
18639745Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.Brain Res Bull2008
18597510Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.Bioconjug Chem2008
18620447Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules.Bioconjug Chem2008
17152090A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.Synapse2007
17552504Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.J Med Chem2007
17711320Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.Bioconjug Chem2007
17725340Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.J Med Chem2007
17060492Salvinorin A: allosteric interactions at the mu-opioid receptor.J Pharmacol Exp Ther2007
16165252Regulation of the rat brain endothelin system by endogenous beta-endorphin.Peptides2006
16672569Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.J Pharmacol Exp Ther2006
15987828Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor.J Pharmacol Exp Ther2005
15937150(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane.J Pharmacol Exp Ther2005
15065220Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.Synapse2004
15541896Intracerebroventricular administration of anti-endothelin-1 IgG selectively upregulates endothelin-A and kappa opioid receptors.Neuroscience2004
152665563,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein.Synapse2004
12422367Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu opioid receptor.Synapse2003
12732339Endogenous CART peptide regulates mu opioid and serotonin 5-HT(2A) receptors.Peptides2003
12825951Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.J Med Chem2003
11954042In vitro and in vivo characterization of [125I]iodomethyllycaconitine in the rat.Synapse2002
12139463Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.J Med Chem2002
12535696Endogenous corticotropin releasing factor regulates adrenergic and opioid receptors.Peptides2002
11071711Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.Synapse2001
11311071Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.J Med Chem2001
11309842Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.Synapse2001
11300879Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.J Med Chem2001
11543951SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.Brain Res Bull2001
11495579Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.J Med Chem2001
11418937[(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter.Synapse2001
10649969Synthesis and pharmacological characterization of [(125)I]iodomethyllycaconitine ([(125)I]iodo-MLA). A new ligand for the alpha(7) nicotinic acetylcholine receptor.J Med Chem2000
108664004-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.Bioorg Med Chem Lett2000
10956228Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers.J Med Chem2000
10479286Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.J Med Chem1999
10188634Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands.Synapse1999
10612597Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.Bioorg Med Chem Lett1999
10571174(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.Bioorg Med Chem Lett1999
9857089Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.J Med Chem1998
9450512Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.Synapse1998
9873693N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.Bioorg Med Chem Lett1998
9599247Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.J Med Chem1998
9493867Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors.Peptides1998
9667975Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.J Med Chem1998
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Collaborators

National Institutes of Health
Co-authored papers 10
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 5
National Cancer Institute, National Institutes of Health
Co-authored papers 5
Center for Interventional Oncology, National Institutes of Health
Co-authored papers 4
Center for Cancer Research
Co-authored papers 3
Boston Children's Hospital
Co-authored papers 1
Co-authored papers 1
College of Medicine, The Ohio State University
Co-authored papers 1
Boston Children's Hospital and Harvard Medical School
Co-authored papers 1
University of Fukui.
Co-authored papers 1
UNC Chapel Hill School of Medicine
Co-authored papers 1
Boston Children's Hospital
Co-authored papers 1
Lieber Institute for Brain Development (LIBD)
Co-authored papers 1
Office of Cancer Clinical Proteomics Research, National Cancer Institute
Co-authored papers 1