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Author Details

Heath E Klock
Merck & Co., Inc.
2002
128
27
PMIDPaper TitleJournal TitlePublished Year
37456510TraceTrack, an open-source software for batch processing, alignment and visualization of sanger sequencing chromatograms.Bioinform Adv2023
32822567A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.Cell2020
30389991TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells.Sci Rep2018
30297964Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.Nat Methods2018
28590752Optimization of an Enzymatic Antibody-Drug Conjugation Approach Based on Coenzyme A Analogs.Bioconjug Chem2017
26588668Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Phosphopantetheinyl Transferases.Bioconjug Chem2015
24888348Molecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome.Protein Sci2014
25044324Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake.Protein Sci2014
23572527Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.J Biol Chem2013
24123814Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.J Bacteriol2013
22211578Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization.Mol Microbiol2012
22984442Structure of a novel winged-helix like domain from human NFRKB protein.PLoS One2012
22844465Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.PLoS One2012
22467785The structure of Mlc titration factor A (MtfA/YeeI) reveals a prototypical zinc metallopeptidase related to anthrax lethal factor.J Bacteriol2012
21082721Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima.Protein Sci2011
21799766Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites.PLoS One2011
21799754Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake.PLoS One2011
21445265Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein.PLoS One2011
19913036Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.J Mol Biol2010
20836087The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu.Protein Sci2010
20869368Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.J Mol Biol2010
20944232Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944231Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944230Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944229Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944228The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944225Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944224Structure of Bacteroides thetaiotaomicron BT2081 at 2.05⿿ÿ resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944223A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2⿿ÿ resolution.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944222Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944221The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944219The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944218Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944217Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944216Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5⿿ÿ resolution.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944214Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944213The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944212Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944211The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45⿿ÿ resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944209Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944208The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944207Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944206The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944205Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20133595Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency.Proc Natl Acad Sci U S A2010
20122942Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair.J Mol Biol2010
20399190Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module.Structure2010
19000695A structural basis for the regulatory inactivation of DnaA.J Mol Biol2009
19482004Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.Anal Biochem2009
19450606Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus.J Mol Biol2009
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Collaborators

Merck & Co., Inc.
Co-authored papers 122
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 105
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
Co-authored papers 104
Joint Center for Structural Genomics
Co-authored papers 103
University of California Riverside
Co-authored papers 103
Rice University
Co-authored papers 102
University of California Riverside School of Medicine
Co-authored papers 97
Genomics Institute of the Novartis Research Foundation
Co-authored papers 93
Stanford University
Co-authored papers 90
University of California
Co-authored papers 90
University of California San Francisco
Co-authored papers 89
Argonne National Laboratory
Co-authored papers 86
Joint Center for Structural Genomics
Co-authored papers 85
Co-authored papers 78
Regeneron Pharmaceuticals, Inc.
Co-authored papers 74
Co-authored papers 71
Co-authored papers 67
Genomics Institute of the Novartis Research Foundation
Co-authored papers 64
Joint Center for Structural Genomics
Co-authored papers 63
Bridge Institute, University of Southern California
Co-authored papers 58
Joint Center for Structural Genomics
Co-authored papers 55
Institute of Science, Banaras Hindu University
Co-authored papers 52
The Joint Center for Structural Genomics, Stanford University
Co-authored papers 50
iHuman Institute, ShanghaiTech University
Co-authored papers 48
University of Tubingen
Co-authored papers 47
Co-authored papers 47
Cardiovascular Institute, Stanford University School of Medicine
Co-authored papers 47
Brown University
Co-authored papers 46
Celgene/Bristol-Myers Squibb Corporation
Co-authored papers 45
Co-authored papers 45