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Author Details

Joachim Frank
Columbia University
1972
351
92
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36747778Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling.bioRxiv2023
34799235Contributions of single-particle cryoelectron microscopy toward fighting COVID-19.Trends Biochem Sci2022
35617047RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis.J Clin Invest2022
35822879Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.EMBO J2022
35931078Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential.Stem Cell Reports2022
36258699Recovery of Conformational Continuum From Single-Particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth.IEEE Trans Comput Imaging2022
33007145A Time-Resolved Cryo-EM Study of Saccharomyces cerevisiae 80S Ribosome Protein Composition in Response to a Change in Carbon Source.Proteomics2021
33619492A glycan gate controls opening of the SARS-CoV-2 spike protein.bioRxiv2021
34916296Symmetric activation and modulation of the human calcium-sensing receptor.Proc Natl Acad Sci U S A2021
34509504What is in the black box? - A perspective on software in cryoelectron microscopy.Biophys J2021
34413500A glycan gate controls opening of the SARS-CoV-2 spike protein.Nat Chem2021
34077195"Just in Time": The Role of Cryo-Electron Microscopy in Combating Recent Pandemics.Biochemistry2021
33252739Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids.Subcell Biochem2021
32483338Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.Nat Struct Mol Biol2020
31999117POLARIS: Path of Least Action Analysis on Energy Landscapes.J Chem Inf Model2020
33188030Nanobubble-controlled nanofluidic transport.Sci Adv2020
32948759Retrieving functional pathways of biomolecules from single-particle snapshots.Nat Commun2020
32665714Author Correction: Structure of human GABA<sub>B</sub> receptor in an inactive state.Nature2020
32581365Structure of human GABA<sub>B</sub> receptor in an inactive state.Nature2020
32207941Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding.J Chem Inf Model2020
32270040Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.Sci Adv2020
31108498Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.Nature2019
29903714New Insights into Ribosome Structure and Function.Cold Spring Harb Perspect Biol2019
31609474The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.EMBO J2019
31189921The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy.Nat Commun2019
29733411Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A.Nucleic Acids Res2018
30242932On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation.Protein Sci2018
30002838Identification of ions in experimental electrostatic potential maps.IUCrJ2018
30240627Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography.iScience2018
30211483Identification of Changing Ribosome Protein Compositions using Mass Spectrometry.Proteomics2018
29978534Single-Particle Reconstruction of Biological Molecules-Story in a Sample (Nobel Lecture).Angew Chem Int Ed Engl2018
30285306Critical Role for Saccharomyces cerevisiae Asc1p in Translational Initiation at Elevated Temperatures.Proteomics2018
30509977Structure and activity of lipid bilayer within a membrane-protein transporter.Proc Natl Acad Sci U S A2018
29494255The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes: A Decade of Structures Unraveling the Mechanics of the Process.Annu Rev Biophys2018
29605908Time-Resolved Cryo-electron Microscopy Using a Microfluidic Chip.Methods Mol Biol2018
29464565Ryanodine Receptor Structure and Function in Health and Disease.Subcell Biochem2018
29368918New Opportunities Created by Single-Particle Cryo-EM: The Mapping of Conformational Space.Biochemistry2018
27750394Determination of the ribosome structure to a resolution of 2.5 ÿ by single-particle cryo-EM.Protein Sci2017
28199113Quantitative Characterization of Domain Motions in Molecular Machines.J Phys Chem B2017
28138066The translation elongation cycle-capturing multiple states by cryo-electron microscopy.Philos Trans R Soc Lond B Biol Sci2017
28472657Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.Neuron2017
28344776The mechanism of translation.F1000Res2017
28179369Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.EMBO J2017
28286002A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM.Structure2017
28625887Time-resolved cryo-electron microscopy: Recent progress.J Struct Biol2017
28737760Channel opening and gating mechanism in AMPA-subtype glutamate receptors.Nature2017
28055037Advances in the field of single-particle cryo-electron microscopy over the last decade.Nat Protoc2017
26884261Continuous changes in structure mapped by manifold embedding of single-particle data in cryo-EM.Methods2016
26566976Generalized single-particle cryo-EM--a historical perspective.Microscopy (Oxf)2016
26520784Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule.Microscopy (Oxf)2016
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Collaborators

Pawel A Penczek
The University of Texas, McGovern Medical School
Co-authored papers 43
Rajendra K Agrawal
School of Public Health, University at Albany
Co-authored papers 33
Christian M T Spahn
Institut fur Medizinische Physik und Biophysik, Charite-Universitatsmedizin Berlin
Co-authored papers 21
Jayati Sengupta
Institute of Child Health
Co-authored papers 18
Mikel Valle
Center for Cooperative Research in Biosciences (CIC bioGUNE)
Co-authored papers 15
Haixiao Gao
Howard Hughes Medical Institute, Inc. at the Wadsworth Center
Co-authored papers 14
Jose Maria Carazo
National Centre for Biotechnology (CNB CSIC), Campus Universidad Autonoma de Madrid
Co-authored papers 12
Ming Sun
Columbia University
Co-authored papers 10
Derek J Taylor
Case Western Reserve University
Co-authored papers 8
Roland Beckmann
University of Munich
Co-authored papers 7
Wayne A Hendrickson
Columbia University
Co-authored papers 7
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 6
Wah Chiu
Stanford University
Co-authored papers 6
Stephen C Harvey
University of Pennsylvania
Co-authored papers 5
Nenad Ban
Institute of Molecular Biology and Biophysics, ETH Zurich
Co-authored papers 4
William J Rice
New York University Grossman School of Medicine
Co-authored papers 4
G??nter Blobel
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 4
Narayanan Eswar
University of California at San Francisco
Co-authored papers 4
Lawrence Shapiro
Zuckerman Mind Brain Behaviour Institute
Co-authored papers 3
James Andrew McCammon
Co-authored papers 3
Scott M Stagg
Florida State University
Co-authored papers 3
Bridget Carragher
Columbia University
Co-authored papers 3
Lillian T Chong
Co-authored papers 2
Rommie E Amaro
University of California
Co-authored papers 2
Rick K Huang
National Cancer Institute, National Institutes of Health
Co-authored papers 2
J. B Heymann
Frederick National Laboratory for Cancer Research, Inc.
Co-authored papers 2
Willy Wriggers
Old Dominion University
Co-authored papers 2
Alasdair C Steven
National Institutes of Health
Co-authored papers 2
Charles L Brooks
University of Michigan ann arbor
Co-authored papers 2
Michael S Chapman
University of Missouri
Co-authored papers 2
Release 1.2