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Author Details

Alice Dawson
University of Dundee
2002
39
17
PMIDPaper TitleJournal TitlePublished Year
36048081Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (-)-hosieine-A.Acta Crystallogr F Struct Biol Commun2022
36442320Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification.EBioMedicine2022
36037410Toolkit of Approaches To Support Target-Focused Drug Discovery for <i>Plasmodium falciparum</i> Lysyl tRNA Synthetase.ACS Infect Dis2022
36220877Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.Nat Commun2022
34484803Hemi-paraplegia and hemi-anaesthesia in the inflammatory bowel disease clinic.JRSM Open2021
31859406A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels.Chembiochem2020
30950822The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei.Acta Crystallogr F Struct Biol Commun2019
31709057Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein.IUCrJ2019
30839287An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement.Acta Crystallogr F Struct Biol Commun2019
28983525Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit <i>Trypanosoma brucei</i> Pteridine Reductase in Support of Early-Stage Drug Discovery.ACS Omega2017
28333400An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.ChemMedChem2017
27391210The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme.FEBS Lett2016
24410837Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.BMC Struct Biol2014
23722836Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
22015585On the electronic structure of nitro-substituted bipyridines and their platinum complexes.Dalton Trans2012
22289056Conserved signal peptide recognition systems across the prokaryotic domains.Biochemistry2012
21513522Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity.BMC Struct Biol2011
20600129Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis.J Mol Biol2010
21123874High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target.Acta Crystallogr D Biol Crystallogr2010
20693687Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery.Acta Crystallogr D Biol Crystallogr2010
20801163Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid.Mol Biochem Parasitol2010
19035598Isotopic polymorphism in pyridine.Angew Chem Int Ed Engl2009
19320487A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.J Med Chem2009
18385152TarO: a target optimisation system for structural biology.Nucleic Acids Res2008
18983854Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase).J Mol Biol2008
18682650(S,S)-4''-Cyano-7,7''-dimethoxy-3',6'-dioxodispiro[indane-2,2'-piperazine-5',2''-indane]-4-carboxamide methanol solvate: interrupting the amide-to-amide hydrogen-bonded tape.Acta Crystallogr C2008
17360522Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis.Proc Natl Acad Sci U S A2007
18001112Photoelectron spectroscopy and electronic structure calculations of d1 vanadocene compounds with chelated dithiolate ligands: implications for pyranopterin Mo/W enzymes.Inorg Chem2007
16263102Synthesis, structure and reactivity of 5-pyranosyl-1,3,4-oxathiazol-2-ones.Carbohydr Res2006
17077484The nucleotide-binding site of Aquifex aeolicus LpxC.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
17154516Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands.J Med Chem2006
16813405Models of the cytochromes: crystal structures and EPR spectral characterization of low-spin bis-imidazole complexes of (OETPP)Fe(III) having intermediate ligand plane dihedral angles.Inorg Chem2006
16968221Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.Mol Microbiol2006
16470886A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin.Chemistry2006
15987150Synthesis of 1,10-dimethylbicyclo[8.8.8]hexacosane and 1,10-dihydroxybicyclo[8.8.8]hexacosane.Org Lett2005
16296844Barriers to racemization in C3-symmetric complexes containing the hydrotris(2-mercapto-1-ethylimidazolyl)borate (Tm(Et)) ligand.Inorg Chem2005
14657383Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.Proc Natl Acad Sci U S A2003
14703829Pressure-induced formation of a solvate of paracetamol.Chem Commun (Camb)2003
12456981Pressure-induced polymorphism in phenol.Acta Crystallogr B2002
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Collaborators

University of Western Ontario
Co-authored papers 1
University Hospital of Parma
Co-authored papers 1
Vrije Universiteit Amsterdam
Co-authored papers 1
Location Vrije Universiteit Amsterdam
Co-authored papers 1
The University of Illinois at Chicago
Co-authored papers 1
Jewish General Hospital, McGill University
Co-authored papers 1
University of Western Ontario
Co-authored papers 1
Maastricht University Medical Centre
Co-authored papers 1
Center for Molecular Biology (ZMBH), Heidelberg University
Co-authored papers 1
Schulich School of Medicine & Dentistry, Western University
Co-authored papers 1
University of British Columbia
Co-authored papers 1
University of British Columbia
Co-authored papers 1
University of Western Ontario
Co-authored papers 1
University of St Andrews
Co-authored papers 1
University of Western Ontario
Co-authored papers 1
Western University
Co-authored papers 1
Fondazione IRCCS Istituto Nazionale dei Tumouri
Co-authored papers 1
Heidelberg Institute for Theoretical Studies (HITS gGmbH)
Co-authored papers 1
Heinrich-Heine University
Co-authored papers 1
University of Dundee
Co-authored papers 1
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, University of Milan
Co-authored papers 1
Jewish General Hospital
Co-authored papers 1
University of Western Ontario
Co-authored papers 1
Stanford University
Co-authored papers 1
Western University
Co-authored papers 1
University of Western Ontario
Co-authored papers 1
Cumming School of Medicine, University of Calgary
Co-authored papers 1
University of California los angeles
Co-authored papers 1
University of Western Ontario
Co-authored papers 1
Schulich School of Medicine & Dentistry, Western University, Victoria Hospital
Co-authored papers 1