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Author Details

Michael N Sack
1992
133
54
PMIDPaper TitleJournal TitlePublished Year
36535215The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis.Biochem Biophys Res Commun2023
37586364Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects.2023
37610299MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells.2023
36759571Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1.2023
37128607N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4<sup>+</sup>T cell responsiveness.iScience2023
35025762Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.Journal of Clinical Investigation2022
36216719Linking nutrient sensing, mitochondrial function, and PRR immune cell signaling in liver disease.Trends in Immunology2022
36070637Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutations.Stem Cell Res2022
35538890Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma.Clinical and Translational Medicine2022
36644286Tackling Inflammation at its Source in Heart Failure: Are Mitochondria the Key?2022
34449775Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans.PLoS Genetics2021
34079545Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance.Frontiers in Immunology2021
33796130Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection.Frontiers in Genetics2021
33629936BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation.2021
33463543Proteomic and metabolomic advances uncover biomarkers of mitochondrial disease pathophysiology and severity.Journal of Clinical Investigation2021
33723462Fasting-induced FOXO4 blunts human CD4<sup>+</sup> T helper cell responsiveness.Nat Metab2021
33980856Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling.Nature Communications2021
33924911Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4<sup>+</sup> T Cell Responsiveness.Nutrients2021
32599084The emerging roles of GCN5L1 in mitochondrial and vacuolar organelle biology.Biochimica et Biophysica Acta - Gene Regulatory Mechanisms2021
31344750Mitochondrial General Control of Amino Acid Synthesis 5 Like 1 Regulates Glutaminolysis, Mammalian Target of Rapamycin Complex 1 Activity, and Murine Liver Regeneration.Hepatology2020
31665251The enigma of anti-inflammatory therapy for the management of heart failure.Cardiovascular Research2020
32970530Rethinking Protein Acetylation in Pressure Overload-Induced Heart Failure.Circulation Research2020
30776374Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.Journal of Molecular and Cellular Cardiology2019
31733441Generation of two induced pluripotent stem cell lines (NHLBIi001-A and NHLBIi001-B) from a healthy Caucasian female volunteer with normal cardiac function.Stem Cell Res2019
31138772Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.Biochemical Journal2019
29477615GCN5L1/BLOS1 Links Acetylation, Organelle Remodeling, and Metabolism.Trends in Cell Biology2018
30021766A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.Journal of Immunology2018
30059015Mitochondrial fidelity and metabolic agility control immune cell fate and function.Journal of Clinical Investigation2018
30378174Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation.GLIA2018
30333138GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking.Journal of Cell Science2018
30373851Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4<sup>+</sup> T Cell Activation.J Immunol2018
30323061The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.Journal of Biological Chemistry2018
29988090Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.Nat Immunol2018
27942750The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome.Cellular and Molecular Life Sciences2017
28683968Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series.Journal of the American College of Cardiology2017
28900165GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis.Nature Communications2017
28584055Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2.Journal of Biological Chemistry2017
28522833Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress.Sci Rep2017
29259245ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells.Sci Rep2017
27647490The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation.Journal of Physiology2016
26799652Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy2016
27126807Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.Circ Res2016
26529255Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects.Journal of Clinical Investigation2015
25505263Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.Journal of Biological Chemistry2015
26388266Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.Journal of Molecular and Cellular Cardiology2015
24966184Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.Cardiovasc Res2014
24356961GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy.Journal of Biological Chemistry2014
24525425Regulation of autophagy and mitophagy by nutrient availability and acetylation.2014
24006259Restricted mitochondrial protein acetylation initiates mitochondrial autophagy.Journal of Cell Science2013
24039623Obesity and Cardiac Function - The Role of Caloric Excess and its Reversal.Drug Discovery Today: Disease Mechanisms2013
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