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Author Details

Sandra A Rempel
Henry Ford Hospital
1988
52
31
PMIDPaper TitleJournal TitlePublished Year
24862407Loss of Sparc in p53-null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival.Brain Pathol2015
24477622Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas.J Neurooncol2014
23144078TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo.Neuro Oncol2013
23390502MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.PLoS One2013
23382286PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma.Neuro Oncol2013
23548312Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal.Oncotarget2013
22114076Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma.Carcinogenesis2012
22480225Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival.Mol Cancer2012
22422183Correlation of perfusion parameters with genes related to angiogenesis regulation in glioblastoma: a feasibility study.AJNR Am J Neuroradiol2012
21688302Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model.J Cell Biochem2011
21788343Cilengitide induces autophagy-mediated cell death in glioma cells.Neuro Oncol2011
20472716PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling.Neuro Oncol2010
19027948Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability.Biomaterials2009
18403493GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.Neuro Oncol2008
18442089HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion.Glia2008
18350569SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion.Int J Cancer2008
17490812SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells.Neurosci Lett2007
17344888Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response.Genes Immun2007
17297440PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.Oncogene2007
16115889SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity.J Biol Chem2005
15230275International Hermelin brain tumor symposium on matricellular proteins in normal and cancer cell-matrix interactions.Matrix Biol2004
14555516Meningiomas: analysis of loss of heterozygosity on chromosome 10 in tumor progression and the delineation of four regions of chromosomal deletion in common with other cancers.Clin Cancer Res2003
14565160SPARC affects glioma cell growth differently when grown on brain ECM proteins in vitro under standard versus reduced-serum stress conditions.Neuro Oncol2003
14555517Meningiomas: loss of heterozygosity on chromosome 10 and marker-specific correlations with grade, recurrence, and survival.Clin Cancer Res2003
11774351Studying the heterogeneity of brain tumors using medium throughput LOH analysis.Cytometry2002
12414657Secreted protein acidic and rich in cysteine promotes glioma invasion and delays tumor growth in vivo.Cancer Res2002
12510773cDNA array analysis of SPARC-modulated changes in glioma gene expression.J Neurooncol2002
11770303Molecular biology of nervous system tumors.Hematol Oncol Clin North Am2001
11716067SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins.J Neurooncol2001
11696458New approaches to the molecular biology, classification, and therapy of nervous system tumors: a workshop of the National Institutes of Health Pathology B study section.Am J Pathol2001
11692657New innovations and developments for glioma treatment.Clin Neurosurg2001
10778947Carboxyamido-triazole induces apoptosis in bovine aortic endothelial and human glioma cells.Clin Cancer Res2000
11302248Use of horizontal ultrathin gel electrophoresis to analyze allelic deletions in chromosome band 11p15.5 in gliomas.Neuro Oncol2000
10861485Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC.Int J Cancer2000
10995878A study of SPARC and vitronectin localization and expression in pediatric and adult gliomas: high SPARC secretion correlates with decreased migration on vitronectin.Int J Oncol2000
10888600Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas.Hum Mol Genet2000
10656438Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.Clin Cancer Res2000
10571408Increased SPARC expression promotes U87 glioblastoma invasion in vitro.Int J Dev Neurosci1999
10037170SPARC: a potential diagnostic marker of invasive meningiomas.Clin Cancer Res1999
9862633SPARC: a signal of astrocytic neoplastic transformation and reactive response in human primary and xenograft gliomas.J Neuropathol Exp Neurol1998
10235000Expression of transforming growth factor-beta complex in arteriovenous malformations.Neurol Med Chir (Tokyo)1998
10343969Temporal profile of connexin 43 mRNA expression in a tetanus toxin-induced seizure disorder.Mol Chem Neuropathol1998
10030674Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast.Oncogene1998
9619352Molecular biology of central nervous system tumors.Curr Opin Oncol1998
9437659Connexin 43 mRNA expression in two experimental models of epilepsy.Mol Chem Neuropathol1997
9184118Hippocampal connexin 43 expression in human complex partial seizure disorder.Exp Neurol1997
9347980Cathepsin B and middle cerebral artery occlusion in the rat.J Neurosurg1997
7862624Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.Proc Natl Acad Sci U S A1995
7954439Cathepsin B expression and localization in glioma progression and invasion.Cancer Res1994
8439970Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene.Cancer Res1993
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Collaborators

Ontario Brain Institute
Co-authored papers 11
Case Western Reverse University School of Medicine
Co-authored papers 11
Henry Ford Hospital
Co-authored papers 8
MD Anderson Cancer Center
Co-authored papers 6
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Co-authored papers 6
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 5
Co-authored papers 4
9Virginia Commonwealth University
Co-authored papers 3
Ludwig Institute for Cancer Research, University of California San Diego
Co-authored papers 3
Mahidol University
Co-authored papers 2
Co-authored papers 2
Oakland University William Beaumont School of Medicine
Co-authored papers 2
Heersink School of Medicine, University of Alabama at Birmingham
Co-authored papers 2
Brady Urological Institute, Johns Hopkins University School of Medicine
Co-authored papers 2
Charite - Universitatsmedizin Berlin
Co-authored papers 1
Co-authored papers 1
Rutgers Cancer Institute of New Jersey
Co-authored papers 1
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Co-authored papers 1
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Co-authored papers 1
Co-authored papers 1
UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Co-authored papers 1
Regeneron Pharmaceuticals Inc.
Co-authored papers 1
University of Pennsylvania School of Medicine
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Division of Pharmacovigilance I, Center for Drug Evaluation and Research
Co-authored papers 1
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University of California Davis
Co-authored papers 1