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Author Details

Elena Evdokimova
University of Toronto
2002
61
25
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37973888Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.Nat Chem Biol2024
36719236Thermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins.Appl Environ Microbiol2023
35338238Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.Commun Biol2022
35512834Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <i>Candida albicans</i>.Life Sci Alliance2022
36229448Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections.Nat Commun2022
34081630Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.JCI Insight2021
33563840ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin.mBio2021
34235498Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies.Cell Rep Methods2021
31886667One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases.J Am Chem Soc2020
31876342Structure of the full-length Serratia marcescens acetyltransferase AAC(3)-Ia in complex with coenzyme A.Protein Sci2020
31924499Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.Cell Chem Biol2020
31891426Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa.Protein Sci2020
29317655The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.Nat Commun2018
30382091Identification and characterization of a large family of superbinding bacterial SH2 domains.Nat Commun2018
29642013Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.Cell Rep2018
29634241Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.ACS Infect Dis2018
29631403Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.ACS Chem Biol2018
29301934The <i>Legionella pneumophila</i> effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.J Biol Chem2018
27785912Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.ACS Infect Dis2017
28130301Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies.Appl Environ Microbiol2017
27986836Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.Mol Syst Biol2016
26507654Structure-Function Analysis of a Mixed-linkage β-Glucanase/Xyloglucanase from the Key Ruminal Bacteroidetes Prevotella bryantii B(1)4.J Biol Chem2016
25406313Structural and functional characterization of a ketosteroid transcriptional regulator of Mycobacterium tuberculosis.J Biol Chem2015
26265719Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases.mBio2015
26426142Crystal structure of the Legionella pneumophila Lem10 effector reveals a new member of the HD protein superfamily.Proteins2015
26071590Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.J Biol Chem2015
25900373Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).J Mol Biol2015
24711382Structural basis for the evolution of vancomycin resistance D,D-peptidases.Proc Natl Acad Sci U S A2014
25223995Potential for reduction of streptogramin A resistance revealed by structural analysis of acetyltransferase VatA.Antimicrob Agents Chemother2014
24590716High-throughput crystallization screening.Methods Mol Biol2014
23229889Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.Proteins2013
23745136Structural and functional insight into the universal stress protein family.Evol Appl2013
23758273Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.Biochem J2013
22128181Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase.J Biol Chem2012
22439787Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801.Biochem J2012
22519667Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica.Biochem J2012
21084294Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.J Biol Chem2011
22195561A small molecule discrimination map of the antibiotic resistance kinome.Chem Biol2011
21548881Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme.Biochem J2011
20670890PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica.Mol Cell2010
18056714Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.J Biol Chem2008
19898606Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1.Cryst Growth Des2008
19001261Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria.Proc Natl Acad Sci U S A2008
17426033Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator.J Biol Chem2007
17982461In situ proteolysis for protein crystallization and structure determination.Nat Methods2007
17588774Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.J Struct Biol2007
17586769Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene.Protein Sci2007
17669425Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non-ribosomal peptide synthases.J Mol Biol2007
16582479Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
164936571.6 A crystal structure of a PA2721 protein from pseudomonas aeruginosa--a potential drug-resistance protein.Proteins2006
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Collaborators

University of Toronto
Co-authored papers 57
University of Toronto
Co-authored papers 18
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 13
University of Toronto
Co-authored papers 8
University of South Carolina, Michigan State University
Co-authored papers 4
University of Virginia
Co-authored papers 4
University of Toronto
Co-authored papers 4
University of Western Ontario
Co-authored papers 3
University of Toronto
Co-authored papers 3
Yale University
Co-authored papers 2
EMBL--European Bioinformatics Institute
Co-authored papers 2
University of Toronto
Co-authored papers 2
University of Toronto
Co-authored papers 2
European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 2
Miami University
Co-authored papers 1
Kangwon National University College of Medicine
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1
West China Hospital, Sichuan University
Co-authored papers 1
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Co-authored papers 1
Ecole Polytechnique Federale de Lausanne, Global Health Institute
Co-authored papers 1
University of Windsor
Co-authored papers 1
Karolinska Institutet, BioClinicum J6
Co-authored papers 1
University of Florida
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
College Street, University of Toronto
Co-authored papers 1
MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh
Co-authored papers 1
University of Virginia
Co-authored papers 1
Pacific Northwest National Laboratory
Co-authored papers 1