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Author Details

Claire Palles
Institute of Cancer and Genomic Sciences, University of Birmingham
2006
83
34
PMIDPaper TitleJournal TitlePublished Year
36286845Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.Cancer Res2023
37256751Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency.Cell Rep2023
36993383Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls.Res Sq2023
37380644Author Correction: Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair.Nat Commun2023
37336879Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair.Nat Commun2023
37066289Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls.medRxiv2023
36782065Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.Nat Genet2023
36539618Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.Nat Genet2023
35882562GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.Gut2023
33948826The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management.Fam Cancer2022
35709760eQTL Set-Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma.Cancer Epidemiol Biomarkers Prev2022
35504971Publisher Correction: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.Nature2022
35467766Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome.Int J Cancer2022
35460607Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.Am J Hum Genet2022
35655252Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes.Genome Med2022
36564402Germline genetic variation and predicting immune checkpoint inhibitor induced toxicity.NPJ Genom Med2022
36108087Familial component of early-onset colorectal cancer: opportunity for prevention.Br J Surg2022
35188551Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19.JAMA Netw Open2022
35140396Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.Nature2022
34761389Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy.Br J Haematol2022
34187846Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.Gut2022
34301621COVID-19 in children with haematological malignancies.Arch Dis Child2022
32851660Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.Int J Cancer2021
33558336Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response.Cancer Res2021
33805100An Evaluation of the Diagnostic Accuracy of a Panel of Variants in <i>DPYD</i> and a Single Variant in ENOSF1 for Predicting Common Capecitabine Related Toxicities.Cancers (Basel)2021
34758253100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.N Engl J Med2021
34594041Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.Nat Genet2021
34270794Genome-wide association studies of toxicity to oxaliplatin and fluoropyrimidine chemotherapy with or without cetuximab in 1800 patients with advanced colorectal cancer.Int J Cancer2021
33300568Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma.Carcinogenesis2021
32229180Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration.J Mol Diagn2020
31668584Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.Lancet Gastroenterol Hepatol2020
31838077Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis.Pharmacol Res2020
31748258Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies.Cancer Epidemiol Biomarkers Prev2020
31822785Reply to: "Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient".J Hum Genet2020
32473682COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study.Lancet2020
30649440Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer.J Natl Cancer Inst2019
31530880The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.Sci Rep2019
31486228ToxNav germline genetic testing and PROMinet digital mobile application toxicity monitoring: Results of a prospective single-center clinical utility study-PRECISE study.Cancer Med2019
31095950A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer.Gastroenterology2019
30716477No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study.Clin Gastroenterol Hepatol2019
28960316Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.Int J Cancer2018
30177804The evolutionary landscape of colorectal tumorigenesis.Nat Ecol Evol2018
30093612Identification of nine new susceptibility loci for endometrial cancer.Nat Commun2018
30042065Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.Lancet Gastroenterol Hepatol2018
29604063Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.J Pathol2018
27486097Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.Gut2017
28340513Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.Int J Cancer2017
28829991Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.Eur J Cancer2017
26691890The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer.J Clin Endocrinol Metab2016
27329137Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.Nat Commun2016
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Collaborators

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Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg
Co-authored papers 6
German Cancer Research Center (DKFZ)
Co-authored papers 6
Institute of Human Genetics, University Hospital Bonn
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University of Cambridge
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UCSF Helen Diller Family Comprehensive Cancer Center
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Netherlands Cancer Institute
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Cancer Research UK Cambridge Institute, University of Cambridge
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