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Author Details

David Fushman
University of Maryland, College Park
1990
138
43
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37185902Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.Nat Commun2023
37788430Conformational Tuning Shapes the Balance between Functional Promiscuity and Specialization in Paralogous <i>Plasmodium</i> Acyl-CoA Binding Proteins.Biochemistry2023
37938554Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation.Nat Commun2023
35547846Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.bioRxiv2023
35107780Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa.Biomol NMR Assign2022
35380792Site-Specific Detection and Characterization of Ubiquitin Carbamylation.Biochemistry2022
36624758Quantum computation of molecular structure using data from challenging-to-classically-simulate nuclear magnetic resonance experiments.PRX quantum2022
36370534Editorial overview: Biophysical methods: Exploring structures in motions, from biomolecules to cells, and how to drug them.Curr Opin Struct Biol2022
36183447Reweighting methods for elucidation of conformation ensembles of proteins.Curr Opin Struct Biol2022
35120596Tsg101/ESCRT-I recruitment regulated by the dual binding modes of K63-linked diubiquitin.Structure2022
34027941<sup>15</sup>N NMR studies provide insights into physico-chemical properties of room-temperature ionic liquids.Phys Chem Chem Phys2021
33617881Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1.J Biol Chem2021
34761751Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions.Elife2021
34458819Correction: <i>In vivo</i> modulation of ubiquitin chains by <i>N</i>-methylated non-proteinogenic cyclic peptides.RSC Chem Biol2021
34559559Ubiquitin is a carbon dioxide-binding protein.Sci Adv2021
34364874A novel recognition site for polyubiquitin and ubiquitin-like signals in an unexpected region of proteasomal subunit Rpn1.J Biol Chem2021
32350255Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.Nat Commun2020
31970984High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1.J Am Chem Soc2020
31677892Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1.Structure2020
32752665SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations.J Chem Phys2020
32364696Mechanism of Catalysis by l-Asparaginase.Biochemistry2020
30668904Ubiquitin Chains Bearing Genetically Encoded Photo-Cross-Linkers Enable Efficient Covalent Capture of (Poly)ubiquitin-Binding Domains.Biochemistry2019
31699778Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.Genes Dev2019
31182821De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains.Nat Chem2019
31040281A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair.Nat Commun2019
30347468Top-down analysis of novel synthetic branched proteins.J Mass Spectrom2019
29513006Top-Down Analysis of Branched Proteins Using Mass Spectrometry.Anal Chem2018
30097175Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.Biophys J2018
30269291Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention.Biophys Rev2018
30605130Neutron scattering in the biological sciences: progress and prospects.Acta Crystallogr D Struct Biol2018
29422536Impact of different ionization states of phosphorylated Serine-65 on ubiquitin structure and interactions.Sci Rep2018
27991780Graded Structural Polymorphism in a Bacterial Thermosensor Protein.J Am Chem Soc2017
28197608The dynamic mechanism of RASSF5 and MST kinase activation by Ras.Phys Chem Chem Phys2017
28330605Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.Cell Chem Biol2017
28267209Identification of primary and secondary UBA footprints on the surface of ubiquitin in cell-mimicking crowded solution.FEBS Lett2017
29153505Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.Structure2017
28597297Intrinsic protein disorder in oncogenic KRAS signaling.Cell Mol Life Sci2017
28530812Probing the Binding Modes of a Multidomain Protein to Lipid-based Nanoparticles by Relaxation-based NMR.J Phys Chem Lett2017
28686836Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.Anal Chem2017
28052234Exploring Polyubiquitin as a Flexible Multiple-Ligand Binding Platform.Structure2017
26876099Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.Structure2016
28239975Preparing to read the ubiquitin code: top-down analysis of unanchored ubiquitin tetramers.J Mass Spectrom2016
26422168Linkage-specific conformational ensembles of non-canonical polyubiquitin chains.Phys Chem Chem Phys2016
27643882RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro.Curr Opin Struct Biol2016
27861798Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB<sup>+1</sup>.FEBS Lett2016
27041663Preparing to read the ubiquitin code: characterization of ubiquitin trimers by top-down mass spectrometry.J Mass Spectrom2016
25389291Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.J Biol Chem2015
26182356Base-CP proteasome can serve as a platform for stepwise lid formation.Biosci Rep2015
26182167Unexpected trypsin cleavage at ubiquitinated lysines.Anal Chem2015
26044033Information content of long-range NMR data for the characterization of conformational heterogeneity.J Biomol NMR2015
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Collaborators

Carlos A Casta??eda
Syracuse University, USA Bioinspired Institute
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David Cowburn
Albert Einstein College of Medicine
Co-authored papers 15
Michael H Glickman
Technion-Israel Institute of Technology
Co-authored papers 11
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Co-authored papers 8
Hyunbum Jang
Co-authored papers 7
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University of Maryland, College Park
Co-authored papers 7
Ruth Nussinov
Sackler School of Medicine, Tel Aviv University
Co-authored papers 7
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The Fenway Institute
Co-authored papers 5
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Technion-Israel Institute of Technology
Co-authored papers 4
Zanlin Yu
University of California at San Francisco
Co-authored papers 3
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University of California davis
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Princeton University
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Center for Structural Biology of Infectious Diseases, University of Chicago
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Molecular Biology Institute, University of California los angeles
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University of California San Francisco
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Leiden University Medical Center
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Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Timothy A Lewis
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Daniela Hoeller
Institute of Biochemistry II, Goethe University
Co-authored papers 1
Elah Pick
University of Haifa
Co-authored papers 1
Allan M Weissman
Center for Cancer Research, National Institutes of Health
Co-authored papers 1
Clinton Yu
University of California Irvine
Co-authored papers 1
Farid El Oualid
The Netherlands Cancer Institute
Co-authored papers 1
Lan Huang
University of California Irvine
Co-authored papers 1
Steven P Gygi
Harvard Medical School
Co-authored papers 1
Frank Gabel
University Grenoble Alpes, CNRS
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Paul W Fenimore
Co-authored papers 1
Alexandre M J J Bonvin
Bijvoet Center for Biomolecular Research, Utrecht University
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Daniel Virgil
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Release 1.2