Skip to Main Content

Author Details

Kelli Kuhen
Genomics Institute of the Novartis Research Foundation
1992
51
32
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
31929001Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.Virology2020
30282735The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.Proc Natl Acad Sci U S A2018
26749441High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.Cell Host Microbe2016
25322084Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.ACS Chem Biol2015
26276895No robust evidence of lumefantrine resistance.Antimicrob Agents Chemother2015
26081265The emerging threat of artemisinin resistance in malaria: focus on artemether-lumefantrine.Expert Rev Anti Infect Ther2015
25984567A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.ACS Infect Dis2015
25568071Direct inhibitors of InhA are active against Mycobacterium tuberculosis.Sci Transl Med2015
24366744KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.Antimicrob Agents Chemother2014
25147620Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.ACS Med Chem Lett2014
24913172KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.Antimicrob Agents Chemother2014
24090347Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents.J Med Chem2013
24900693Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.ACS Med Chem Lett2013
24284631Targeting Plasmodium PI(4)K to eliminate malaria.Nature2013
24307692Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis.Sci Transl Med2013
22524250Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.J Med Chem2012
22500615A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.ACS Chem Biol2012
20813141Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Mol Biochem Parasitol2011
22096101Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.Science2011
21644570Imidazolopiperazines: hit to lead optimization of new antimalarial agents.J Med Chem2011
21502533Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV).Proc Natl Acad Sci U S A2011
20568778Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.J Med Chem2010
21037109Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes.Proc Natl Acad Sci U S A2010
20975714A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.Nat Commun2010
20610151Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.Bioorg Med Chem Lett2010
19879133Cell-based optimization of novel benzamides as potential antimalarial leads.Bioorg Med Chem Lett2009
18579783In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.Proc Natl Acad Sci U S A2008
18854154Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.Cell2008
170350194-Aminopyrimidines as novel HIV-1 inhibitors.Bioorg Med Chem Lett2007
17257639Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening.Virology2007
16352537"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection.J Virol2006
17092919Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries.J Biomol Screen2006
16782337Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.Bioorg Med Chem Lett2006
16781149Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.Bioorg Med Chem Lett2006
16480865Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I.Bioorg Med Chem Lett2006
16464578Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.Bioorg Med Chem Lett2006
16632349Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.Bioorg Med Chem Lett2006
16093555Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities.J Biomol Screen2005
15542635Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach.J Virol2004
12696103Generation of dendritic cells from lentiviral vector-transduced CD34+ cells from HIV+ donors.J Med Virol2003
11602580Differential effects of HIV-1 protease inhibitors on dendritic cell immunophenotype and function.J Biol Chem2001
10942374Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro.Blood2000
10544135Alternative splice variants of the human PKR protein kinase possessing different 5'-untranslated regions: expression in untreated and interferon-treated cells and translational activity.Virology1999
10690406Lentivirus replication and regulation.Annu Rev Genet1999
9927585Mechanism of interferon action: functional characterization of positive and negative regulatory domains that modulate transcriptional activation of the human RNA-dependent protein kinase Pkr promoter.Virology1999
9811730Mechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr gene.J Virol1998
9007065Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes.Virology1997
9114594The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation.Int J Hematol1997
8812437Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog.Genomics1996
8921913Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.Gene1996
  • 1 - 50 of 51

Recommended Authors

Gladstone Institutes
Career Start Year 2015
Number of shared co-authors 0
Johns Hopkins School of Medicine
Career Start Year 2008
Number of shared co-authors 0
University of California San Diego
Career Start Year 2007
Number of shared co-authors 9
St. Jude Children's Research Hospital
Career Start Year 2007
Number of shared co-authors 0
Yale School of Medicine, USA Howard Hughes Medical Institute
Career Start Year 2005
Number of shared co-authors 0
University of Minnesota
Career Start Year 2002
Number of shared co-authors 0
National Center for Advancing Translational Sciences, National Institutes of Health
Career Start Year 2002
Number of shared co-authors 2
Center for Cancer Research, National Cancer Institute
Career Start Year 2001
Number of shared co-authors 1
Pfizer Inc. San Diego
Career Start Year 1998
Number of shared co-authors 1
MRC - University of Glasgow Centre for Virus Research, University of Glasgow
Career Start Year 1998
Number of shared co-authors 1
Pondicherry University
Career Start Year 1997
Number of shared co-authors 1
University of Illinois at Urbana-Champaign
Career Start Year 1995
Number of shared co-authors 2
University of Dundee
Career Start Year 1995
Number of shared co-authors 2
Gladstone Institute of Virology
Career Start Year 1993
Number of shared co-authors 3
University of California los angeles
Career Start Year 1992
Number of shared co-authors 5
National Institutes of Health, National Center for Advancing Translational Sciences
Career Start Year 1992
Number of shared co-authors 2
University of Utah
Career Start Year 1991
Number of shared co-authors 5
Blavatnik Institute, Harvard Medical School
Career Start Year 1990
Number of shared co-authors 0
St. George's University Medical School
Career Start Year 1990
Number of shared co-authors 1
Institute for Genomic Medicine, University of California San Diego
Career Start Year 1990
Number of shared co-authors 1
Merck & Co., Inc.
Career Start Year 1989
Number of shared co-authors 7
Vrije Universiteit Amsterdam (VU)
Career Start Year 1987
Number of shared co-authors 4
University of Southampton Highfield Southampton SO17 1BJ UK.
Career Start Year 1986
Number of shared co-authors 0
UK System Immunity Research Institute, Cardiff University
Career Start Year 1985
Number of shared co-authors 0
Institute of Pharmaceutical Chemistry, Goethe University
Career Start Year 1983
Number of shared co-authors 3
Merck & Co. Inc.
Career Start Year 1983
Number of shared co-authors 7
University of Texas Medical Branch
Career Start Year 1983
Number of shared co-authors 1
University of Washington
Career Start Year 1978
Number of shared co-authors 2
University of Pittsburgh School of Medicine
Career Start Year 1977
Number of shared co-authors 0
Vir Biotechnology Inc.
Career Start Year 1977
Number of shared co-authors 3

Collaborators

University of California San Diego
Co-authored papers 14
Sirna Therapeutics a former subsidiary of Merck & Co., Inc.
Co-authored papers 10
a division of The Scripps Research Institute La Jolla
Co-authored papers 7
Genomics Institute of the Novartis Research Foundation
Co-authored papers 7
Yale University School of Medicine
Co-authored papers 4
Harvard Medical School
Co-authored papers 3
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
The Scripps Research Institute
Co-authored papers 2
Prestige BioPharma Ltd
Co-authored papers 2
Paul-Ehrlich-Institut
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
The Children's Hospital of Philadelphia
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Merck & Co., Inc.
Co-authored papers 1
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 1
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Co-authored papers 1
Institute of Molecular Genetics of the Czech Academy of Sciences
Co-authored papers 1
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
United States Army Medical Research Institute of Infectious Diseases
Co-authored papers 1
Sanford-Burnham Medical Research Institute
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
The Scripps Research Institute
Co-authored papers 1
The Salk Institute for Biological Studies
Co-authored papers 1
University of California irvine
Co-authored papers 1
Merck & Co., Inc.
Co-authored papers 1
Co-authored papers 1
Roche Pharma
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
Merck & Co. Inc.
Co-authored papers 1