Author details

Full Name

Luke L Lairson

Affiliation

The Scripps Research Institute

ORCID

Career Start Year

2003

Papers

H Index

Expertise

CM4AI Collaborator

Trey Ideker (CM4AI)

PMID	Paper Title	Journal Title	Published Year
35931610	Targeting STING to promote antitumor immunity.	Trends Cell Biol	2023
37017374	A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death.	J Am Chem Soc	2023
37248411	Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.	Nat Chem Biol	2023
37116763	Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.	Bioorg Med Chem Lett	2023
37467751	Hydroxyproline metabolism enhances IFN-Î³-induced PD-L1 expression and inhibits autophagic flux.	Cell Chem Biol	2023
36516003	Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.	J Med Chem	2023
36571959	Editorial overview: Modality, discovery, and class.	Curr Opin Chem Biol	2023
36037558	Promoting remyelination: A case study in regenerative medicine.	Curr Opin Chem Biol	2022
36001933	Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers.	Eur J Med Chem	2022
33113406	HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins.	Cell Chem Biol	2021
33508678	Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators.	Bioorg Chem	2021
33778785	Protocol for high-throughput compound screening using flow cytometry in THP-1 cells.	STAR Protoc	2021
34382264	Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base-Pair Behavior: A Biophysical Analysis of dNaM-dTPT3.	Chemistry	2021
34130216	Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.	Bioorg Med Chem	2021
34332037	Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen.	Bioorg Med Chem Lett	2021
32386552	Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis.	Cell Stem Cell	2020
32679091	Into the Unknown: A Chemical Biology Approach Provides Mechanistic Insight into HCV Entry.	Cell Chem Biol	2020
32820126	Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.	Science	2020
32730809	An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.	Cell	2020
30846550	A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.	Proc Natl Acad Sci U S A	2019
31801090	Discovery of Small Molecules for the Reversal of T Cell Exhaustion.	Cell Rep	2019
29131145	Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation.	Nat Chem Biol	2018
30323285	A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.	Nature	2018
30365304	Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.	Biochemistry	2018
29731362	Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.	Bioorg Med Chem Lett	2018
27983788	Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.	Anal Chem	2017
28448069	Systems biology guided by XCMS Online metabolomics.	Nat Methods	2017
28416697	Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.	Proc Natl Acad Sci U S A	2017
29087350	A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.	Proc Natl Acad Sci U S A	2017
28930429	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.	ACS Chem Biol	2017
26831078	Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.	Proc Natl Acad Sci U S A	2016
27652319	A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.	Mol Cell Oncol	2016
27560777	Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses.	Anal Chem	2016
27314875	High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes.	ACS Comb Sci	2016
26270491	A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer.	ACS Chem Biol	2015
24387280	Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.	J Med Chem	2014
23294307	Small molecule-based approaches to adult stem cell therapies.	Annu Rev Pharmacol Toxicol	2013
24107995	A regenerative approach to the treatment of multiple sclerosis.	Nature	2013
21184400	Chemical control of stem cell fate and developmental potential.	Angew Chem Int Ed Engl	2011
21832050	Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni.	J Biol Chem	2011
21547985	Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.	Angew Chem Int Ed Engl	2011
20085741	An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.	Cell Stem Cell	2010
20823227	A small molecule accelerates neuronal differentiation in the adult rat.	Proc Natl Acad Sci U S A	2010
19447925	Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.	Proc Natl Acad Sci U S A	2009
19824695	NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base.	Biochemistry	2009
18518825	Glycosyltransferases: structures, functions, and mechanisms.	Annu Rev Biochem	2008
17220972	Alternative donor substrates for inverting and retaining glycosyltransferases.	Chem Commun (Camb)	2007
17803263	S-alk(en)yl-L-cysteine sulfoxides and relative pungency measurements of photosynthetic and nonphotosynthetic tissues of Allium porrum.	J Agric Food Chem	2007
17518445	Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms.	Biochemistry	2007
16862135	High-throughput screening methodology for the directed evolution of glycosyltransferases.	Nat Methods	2006

1 - 50 of 56

Nehme El-Hachem

Centre Hospitalier Universitaire Sainte-Justine Research Centre

Career Start Year 2011

Number of shared co-authors 0

Ahmed Aman

Ontario Institute for Cancer Research, University Avenue

Career Start Year 2007

Number of shared co-authors 0

Kevin Lou

Howard Hughes Medical Institute, University of California san francisco

Career Start Year 2007

Number of shared co-authors 1

Guan Wang

Jilin University

Career Start Year 2005

Number of shared co-authors 0

Aleksandra A Pandyra

Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf

Career Start Year 2003

Number of shared co-authors 0

Anang A Shelat

St. Jude Children's Research Hospital

Career Start Year 2003

Number of shared co-authors 0

Noel Southall

National Center for Advancing Translational Sciences, National Institutes of Health

Career Start Year 2002

Number of shared co-authors 1

Gerald H Lushington

Inc. 16 Dekalb Pike

Career Start Year 2002

Number of shared co-authors 0

Craig J Thomas

Center for Cancer Research, National Cancer Institute

Career Start Year 2001

Number of shared co-authors 1

Jaime H Cheah

Johns Hopkins University School of Medicine

Career Start Year 2000

Number of shared co-authors 1

Alykhan F Shamji

Center for the Science of Therapeutics, Broad Institute

Career Start Year 1999

Number of shared co-authors 3

Rima Al-Awar

Ontario Institute for Cancer Research, University Avenue

Career Start Year 1999

Number of shared co-authors 0

Brent R Stockwell

Columbia University

Career Start Year 1998

Number of shared co-authors 2

Kenneth D Westover

University of Texas Southwestern Medical Center

Career Start Year 1998

Number of shared co-authors 0

Anne Marinier

Institute for Research in Immunology and Cancer

Career Start Year 1997

Number of shared co-authors 0

Ranjini K Sundaram

Yale University

Career Start Year 1996

Number of shared co-authors 0

Jack Taunton

University of California san francisco

Career Start Year 1996

Number of shared co-authors 3

Paul J Hergenrother

University of Illinois at Urbana-Champaign

Career Start Year 1995

Number of shared co-authors 2

Huy Nguyen

The University of Danang-University of Science and Technology

Career Start Year 1993

Number of shared co-authors 0

Michael Ohlmeyer

Atux Iskay LLC

Career Start Year 1993

Number of shared co-authors 0

Marc Ferrer

National Institutes of Health, National Center for Advancing Translational Sciences

Career Start Year 1992

Number of shared co-authors 1

Zhiqiang An

Zhengzhou University

Career Start Year 1992

Number of shared co-authors 0

Carolyn R Bertozzi

Stanford University

Career Start Year 1992

Number of shared co-authors 1

Alessandro Datti

University of Perugia

Career Start Year 1991

Number of shared co-authors 1

Timothy A Lewis

National Institute of Allergy and Infectious Diseases, National Institutes of Health

Career Start Year 1990

Number of shared co-authors 1

Christopher P Austin

St. George's University Medical School

Career Start Year 1990

Number of shared co-authors 4

Mark Namchuk

Blavatnik Institute, Harvard Medical School

Career Start Year 1990

Number of shared co-authors 0

Sally Freeman

Division of Pharmacy and Optometry, University of Manchester

Career Start Year 1988

Number of shared co-authors 1

Kevan M Shokat

University of California San Francisco

Career Start Year 1987

Number of shared co-authors 2

Stefan Knapp

Institute of Pharmaceutical Chemistry, Goethe University

Career Start Year 1983

Number of shared co-authors 2

row(s) 1 - 30 of 30

Costas A Lyssiotis

Co-authored papers 10

Reza Beheshti Zavareh

The Scripps Research Institute

Co-authored papers 7

Natalie C J Strynadka

The University of British Columbia

Co-authored papers 6

Gary Siuzdak

Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute

Co-authored papers 5

Lewis C Cantley

Co-authored papers 4

Hilary P Benton

Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute

Co-authored papers 3

Duane Rinehart

Scripps Center for Metabolomics, The Scripps Research Institute

Co-authored papers 3

Mingliang Fang

Nanyang Technological University, Fudan University

Co-authored papers 3

Tao Huan

University of British Columbia

Co-authored papers 3

Erica M Forsberg

Viral Information Institute, San Diego State University

Co-authored papers 3

Benjamin F Cravatt

Scripps Research Institute

Co-authored papers 3

Aries Aisporna

Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute

Co-authored papers 3

Julijana Ivanisevic

University of Lausanne

Co-authored papers 2

Laura J Niedernhofer

University of Minnesota

Co-authored papers 2

Gregory Krantz

Montana State University

Co-authored papers 2

Farris L Poole

University of Georgia

Co-authored papers 2

Paul S Mischel

Stanford University

Co-authored papers 2

Michael P Thorgersen

University of Georgia

Co-authored papers 2

Michael W W Adams

University of Georgia

Co-authored papers 2

Paul D Robbins

University of Minnesota

Co-authored papers 2

Matthew W Fields

Center for Biofilm Engineering (CBE), Montana State University

Co-authored papers 2

Mansun Law

The Scripps Research Institute

Co-authored papers 1

Erica L Majumder

University of Missouri

Co-authored papers 1

Judy D Wall

University of Missouri

Co-authored papers 1

Rebekah J Karadeema

Co-authored papers 1

Chih-Yuan Chiang

United States Army Medical Research Institute of Infectious Diseases

Co-authored papers 1

Patrick R Griffin

The Scripps Research Institute

Co-authored papers 1

Peter K Vogt

Co-authored papers 1

Markus M Rinschen

Co-authored papers 1

Anthony P Orth

Genomics Institute of the Novartis Research Foundation

Co-authored papers 1

1 - 30

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