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Author Details

John A Widness
The University of Iowa, Roy J. and Lucille A. Carver College of Medicine
1978
221
44
PMIDPaper TitleJournal TitlePublished Year
35274303Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival.Transfusion2022
35691608A Full Target-Mediated Drug Disposition (TMDD) Model to Explain the Changes in Recombinant Human Erythropoietin (rhEpo) Pharmacokinetics in Patients with Different Bone Marrow Integrity Following Hematopoietic Transplantation.J Pharm Sci2022
35513716Early brain and abdominal oxygenation in extremely low birth weight infants.Pediatr Res2022
32564030Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss.Neonatology2020
33382931Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants.N Engl J Med2020
30618050A Mechanism-Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses.J Clin Pharmacol2019
31340188Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens.Eur J Pharm Sci2019
30897226Anemia induces gut inflammation and injury in an animal model of preterm infants.Transfusion2019
29193118In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage.Transfusion2018
30234385A Brief History of Milk Hygiene and Its Impact on Infant Mortality from 1875 to 1925 and Implications for Today: A Review.J Food Prot2018
29895839Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs.Pediatr Res2018
30478521Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs-a Case Example of Erythropoietin.AAPS J2018
29770455Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations.Transfusion2018
28261808Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.Transfusion2017
28189627Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing.J Pharm Sci2017
28099421Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities.Pediatr Res2017
25968472Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.J Clin Lab Anal2016
26502725A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis.AAPS J2016
27424006Research Opportunities to Improve Neonatal Red Blood Cell Transfusion.Transfus Med Rev2016
27215601A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups.AAPS J2016
27213618Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants.JAMA Pediatr2016
27040455Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model.Transfusion2016
27039311Models for the red blood cell lifespan.J Pharmacokinet Pharmacodyn2016
26756783Predictive factors and practice trends in red blood cell transfusions for very-low-birth-weight infants.Pediatr Res2016
26866907Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs.Pediatr Res2016
25362135Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates.Am J Physiol Heart Circ Physiol2015
26363547Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates.J Pediatr2015
25917767Erythropoiesis Stimulating Agents Demonstrate Safety and Show Promise as Neuroprotective Agents in Neonates.J Pediatr2015
26017162A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs.AAPS J2015
25228706High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria.Clin Infect Dis2015
24216541Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.Pediatr Res2014
24969019Measurement of posttransfusion red cell survival with the biotin label.Transfus Med Rev2014
25119336One size will never fit all: the future of research in pediatric transfusion medicine.Pediatr Res2014
24611672Mean remaining life span: a new clinically relevant parameter to assess the quality of transfused red blood cells.Transfusion2014
23033916A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia.Transfusion2013
24108188Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen-mismatched RBCs.Pediatr Res2013
24088873Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion.Pediatr Res2013
23485870Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin.Am J Physiol Regul Integr Comp Physiol2013
22023312Accelerated removal of antibody-coated red blood cells from the circulation is accurately tracked by a biotin label.Transfusion2012
22780899Posttransfusion red blood cell (RBC) survival determined using biotin-labeled RBCs has distinct advantages over labeling with (51) Cr.Transfusion2012
22818544International survey of transfusion practices for extremely premature infants.Semin Perinatol2012
22818543Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.Semin Perinatol2012
22229348Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [14C]cyanate: validation of a model to study human physiology and disease.Transfusion2012
22391632Multidose optimization simulation of erythropoietin treatment in preterm infants.Pediatr Res2012
20630041Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin.Transfusion2011
21678432Differential pharmacokinetic analysis of in vivo erythropoietin receptor interaction with erythropoietin and continuous erythropoietin receptor activator in sheep.Biopharm Drug Dispos2011
21460232Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy.Drug Metab Dispos2011
21456051Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep.Biopharm Drug Dispos2011
21097838Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia.Arch Dis Child Fetal Neonatal Ed2011
21062290Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities.Transfusion2011
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Collaborators

Peter Veng-Pedersen
Division of Pharmaceutics and Translational Therapeutics, University of Iowa
Co-authored papers 58
Ronald G Strauss
University of Iowa Carver College of Medicine
Co-authored papers 32
Donald M Mock
University of Arkansas for Medical Sciences
Co-authored papers 32
Michael K Georgieff
University of Minnesota
Co-authored papers 11
Arnold Pollak
Duke University
Co-authored papers 9
Robert S Franco
University of Cincinnati College of Medicine
Co-authored papers 5
Jose A Cancelas
Cincinnati Children's Hospital Medical Center
Co-authored papers 5
Alexander P J Vlaar
University of Amsterdam
Co-authored papers 3
Haresh Kirpalani
University of Pennsylvania
Co-authored papers 3
Cassandra D Josephson
Emory University School of Medicine
Co-authored papers 3
Brenda B Poindexter
Co-authored papers 2
Robert M Cohen
University of Cincinnati and Cincinnati VA Medical Center
Co-authored papers 2
M??ximo Vento
Neonatal Research Group at the Health Research Institute La Fe (IISLAFE)
Co-authored papers 1
Naomi L C Luban
Children's Research National Institute, Children's National Hospital
Co-authored papers 1
Christopher J Lindsell
Duke University
Co-authored papers 1
Aasma Chaudhary
The Hospital of the University of Pennsylvania
Co-authored papers 1
Nicole P Juffermans
Erasmus University Medical Center
Co-authored papers 1
Ursula Guillen
Sidney Kimmel Medical College of Thomas Jefferson University
Co-authored papers 1
Prakash M Nadkarni
College of Nursing, University of Iowa Hospitals and Clinics
Co-authored papers 1
Michael J Germain
Baystate Medical Center-University of Massachusetts Springfield
Co-authored papers 1
Myra H Wyckoff
University of Texas Southwestern Medical Center
Co-authored papers 1
Release 1.2