| 21937983 | Alzheimer's therapeutics: translation of preclinical science to clinical drug development. | | 2012 |
| 22608070 | Rodent models of TDP-43: recent advances. | Brain Research | 2012 |
| 20382452 | Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. | Neurobiology of Aging | 2012 |
| 22140537 | Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. | PLoS One | 2011 |
| 21490216 | Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. | Journal of Neuroscience | 2011 |
| 20966549 | Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice. | Journal of Alzheimer's Disease | 2011 |
| 22036569 | Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. | Cell | 2011 |
| 20660762 | Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. | Proceedings of the National Academy of Sciences of the United States of America | 2010 |
| 20736350 | Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. | Proceedings of the National Academy of Sciences of the United States of America | 2010 |
| 20371462 | Modeling an anti-amyloid combination therapy for Alzheimer's disease. | Science Translational Medicine | 2010 |
| 19661626 | Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). | J Alzheimers Dis | 2009 |
| 18187333 | Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. | Neurobiol Dis | 2008 |
| 19091971 | Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. | Journal of Neuroscience | 2008 |
| 18305234 | Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. | J Neurosci | 2008 |
| 18385378 | Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. | Proceedings of the National Academy of Sciences of the United States of America | 2008 |
| 17483689 | The etiopathogenesis of Parkinson disease and suggestions for future research. Part II. | J Neuropathol Exp Neurol | 2007 |
| 17913918 | Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. | J Neurosci | 2007 |
| 17827153 | Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. | J Biol Chem | 2007 |
| 17413315 | The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. | J Neuropathol Exp Neurol | 2007 |
| 17093100 | Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. | Journal of Neuroscience | 2006 |
| 16399671 | Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. | Journal of Neuroscience | 2006 |
| 16354928 | BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. | Journal of Neuroscience | 2005 |
| 16107644 | Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. | J Neurosci | 2005 |
| 15755686 | Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. | Neurobiology of Disease | 2005 |
| 15745965 | Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. | J Neurosci | 2005 |
| 15634781 | APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. | Journal of Neuroscience | 2005 |
| 15684072 | Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. | Proc Natl Acad Sci U S A | 2005 |
| 14978286 | Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. | Proc Natl Acad Sci U S A | 2004 |
| 15317865 | Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. | Journal of Neuroscience | 2004 |
| 14690528 | Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations. | Journal of Neurochemistry | 2004 |
| 12716934 | Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. | Journal of Neuroscience | 2003 |
| 12514700 | Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. | Nature Medicine | 2003 |
| 12742740 | Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. | Neurobiology of Disease | 2003 |
| 13678674 | Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. | Neurobiology of Disease | 2003 |
| 14769400 | The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain. | Experimental Neurology | 2003 |
| 11733539 | High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. | J Biol Chem | 2002 |
| 12460454 | Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation. | BMC Cancer | 2002 |
| 11889469 | Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. | Nature Neuroscience | 2002 |
| 12085093 | Genetically engineered mouse models of neurodegenerative diseases. | Nature Neuroscience | 2002 |
| 12084935 | Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. | Proc Natl Acad Sci U S A | 2002 |
| 12427835 | Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. | Journal of Neuroscience | 2002 |
| 11804700 | Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice. | Neurobiology of Aging | 2002 |
| 11224536 | BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. | Nature Neuroscience | 2001 |
| 11765820 | Choroid plexus carcinoma presenting as an intraparenchymal mass. | Journal of Neurosurgery | 2001 |
| 11709540 | Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. | Human Molecular Genetics | 2001 |
| 11526940 | The brain's susceptibility to amyloid plaques. | Science | 2001 |
| 11816796 | Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics. | Journal of Molecular Neuroscience | 2001 |
| 11442350 | Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA. | Neurobiology of Disease | 2001 |
| 11741389 | Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. | Neurobiology of Disease | 2001 |
| 11788049 | beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology. | DNA and Cell Biology | 2001 |