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Author Details

Donald L Price
1953
419
122
PMIDPaper TitleJournal TitlePublished Year
21937983Alzheimer's therapeutics: translation of preclinical science to clinical drug development.2012
22608070Rodent models of TDP-43: recent advances.Brain Research2012
20382452Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Neurobiology of Aging2012
22140537Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.PLoS One2011
21490216Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.Journal of Neuroscience2011
20966549Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice.Journal of Alzheimer's Disease2011
22036569Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.Cell2011
20660762Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.Proceedings of the National Academy of Sciences of the United States of America2010
20736350Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America2010
20371462Modeling an anti-amyloid combination therapy for Alzheimer's disease.Science Translational Medicine2010
19661626Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA).J Alzheimers Dis2009
18187333Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.Neurobiol Dis2008
19091971Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.Journal of Neuroscience2008
18305234Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking.J Neurosci2008
18385378Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.Proceedings of the National Academy of Sciences of the United States of America2008
17483689The etiopathogenesis of Parkinson disease and suggestions for future research. Part II.J Neuropathol Exp Neurol2007
17913918Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.J Neurosci2007
17827153Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.J Biol Chem2007
17413315The etiopathogenesis of Parkinson disease and suggestions for future research. Part I.J Neuropathol Exp Neurol2007
17093100Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.Journal of Neuroscience2006
16399671Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.Journal of Neuroscience2006
16354928BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Journal of Neuroscience2005
16107644Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress.J Neurosci2005
15755686Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities.Neurobiology of Disease2005
15745965Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.J Neurosci2005
15634781APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.Journal of Neuroscience2005
15684072Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.Proc Natl Acad Sci U S A2005
14978286Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.Proc Natl Acad Sci U S A2004
15317865Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.Journal of Neuroscience2004
14690528Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.Journal of Neurochemistry2004
12716934Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Journal of Neuroscience2003
12514700Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.Nature Medicine2003
12742740Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE.Neurobiology of Disease2003
13678674Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice.Neurobiology of Disease2003
14769400The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain.Experimental Neurology2003
11733539High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.J Biol Chem2002
12460454Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation.BMC Cancer2002
11889469Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading.Nature Neuroscience2002
12085093Genetically engineered mouse models of neurodegenerative diseases.Nature Neuroscience2002
12084935Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.Proc Natl Acad Sci U S A2002
12427835Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.Journal of Neuroscience2002
11804700Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.Neurobiology of Aging2002
11224536BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.Nature Neuroscience2001
11765820Choroid plexus carcinoma presenting as an intraparenchymal mass.Journal of Neurosurgery2001
11709540Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.Human Molecular Genetics2001
11526940The brain's susceptibility to amyloid plaques.Science2001
11816796Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics.Journal of Molecular Neuroscience2001
11442350Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.Neurobiology of Disease2001
11741389Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.Neurobiology of Disease2001
11788049beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology.DNA and Cell Biology2001
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Harvard Medical School and McLean Hospital
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Emory University School of Medicine
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Emory University School of Medicine
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University of California San Diego
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Mayo Clinic
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Mayo Clinic Jacksonville
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Institute for Genomic Medicine, University of California San Diego
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Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
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Johns Hopkins University School of Medicine
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Johns Hopkins School of Medicine
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Wilmer Eye Institute, Johns Hopkins Medical Institutions
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Johns Hopkins Hospital
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College of Sciences, The University of Texas at San Antonio
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Baylor College of Medicine
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Johns Hopkins School of Medicine
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Icahn School of Medicine at Mount Sinai
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University of Alabama at Birmingham
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New York Presbyterian Hospital, Columbia University Medical Center
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