Author details

Full Name

Gwo-Yu Chuang

Affiliation

ORCID

Career Start Year

2008

Papers

105

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37098956	Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.		2023
36265510	Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice.	Nat Med	2023
37989731	Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.		2023
35283191	Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.	Journal of Biological Chemistry	2022
35447072	mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron.	Cell	2022
35489332	Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.	Structure	2022
36263060	Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant.	bioRxiv	2022
35537058	-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity.	ACS Chemical Biology	2022
34864901	GLYCO: a tool to quantify glycan shielding of glycosylated proteins.		2022
34753907	Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces.	Nat Commun	2021
33803622	Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria.	Vaccines	2021
33688659	Multimeric nanobodies from camelid engineered mice and llamas potently neutralize SARS-CoV-2 variants.	bioRxiv	2021
33676924	N-terminal Transmembrane-Helix Epitope Tag for X-ray Crystallography and Electron Microscopy of Small Membrane Proteins.	Journal of Molecular Biology	2021
33453152	Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.	Immunity	2021
34098567	Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.	Nature	2021
34135892	Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses.	Front Immunol	2021
34244481	Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.	Nature Communications	2021
33649208	Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.	Proc Natl Acad Sci U S A	2021
33494381	Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses.	Vaccines (Basel)	2021
34408080	Blocking Î±Î² integrin delays viral rebound in SHIV-infected macaques treated with anti-HIV broadly neutralizing antibodies.	Science Translational Medicine	2021
34788599	Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.	Immunity	2021
34731616	Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies.	Cell Rep	2021
34551978	Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses.	Proceedings of the National Academy of Sciences of the United States of America	2021
33271067	Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.	Cell Host Microbe	2020
32268107	Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.	Cell Rep	2020
32130953	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.	Cell Host Microbe	2020
32295908	Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses.	Journal of Virology	2020
31603511	BCrystal: an interpretable sequence-based protein crystallization predictor.		2020
33318483	Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.	NPJ Vaccines	2020
33205023	Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies.	iScience	2020
32877670	Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.	Cell Rep	2020
32755575	Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.	Cell Rep	2020
32637958	Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains.	bioRxiv	2020
33238130	Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.	Cell Reports	2020
33121334	Removal of variable domain -linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies.	mAbs	2020
30713164	Iterative screen optimization maximizes the efficiency of macromolecular crystallization.	Acta Crystallographica Section F:Structural Biology Communications	2019
31586542	Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.	Immunity	2019
31893251	Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B.	Pathogens and Immunity	2019
30604750	Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.	Nature Communications	2019
30471922	Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.	Structure	2019
30876875	Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.	Immunity	2019
30760721	Improvement of antibody functionality by structure-guided paratope engraftment.	Nature Communications	2019
31275220	Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury.	Frontiers in Neurology	2019
31348886	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.	Cell	2019
30995238	Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting.	PLoS One	2019
29069295	PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine.		2018
30355496	Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth.	Cell Reports	2018
29975771	Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.	PLoS Pathog	2018
29867235	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.	Nat Med	2018
30290119	CRISPro: An Automated Pipeline for Protein Conformation Stabilization by Proline.	Journal of Chemical Information and Modeling	2018