Author details

Full Name

Robert J Fletterick

Affiliation

University of California San Francisco

ORCID

Career Start Year

1971

Papers

269

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
30853418	Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.	Cell Chem Biol	2019
30305617	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.	Nat Commun	2018
28981251	Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen.	ACS Chem Biol	2017
28445593	NR5A2 discovering compounds that block tumor growth in PDAC.	J Surg Oncol	2017
26829219	Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome.	J Mol Biol	2016
27467220	Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2).	PLoS One	2016
25499868	Advances in our structural understanding of orphan nuclear receptors.	Trends Biochem Sci	2015
26653140	A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.	Elife	2015
26416531	Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.	J Struct Biol	2015
26207810	The FKBP52 Cochaperone Acts in Synergy with Î²-Catenin to Potentiate Androgen Receptor Signaling.	PLoS One	2015
25825768	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	Proc Natl Acad Sci U S A	2015
25675535	Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.	Proc Natl Acad Sci U S A	2015
25686748	Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.	Nat Commun	2015
24906004	Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients.	Thyroid	2014
25288771	The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.	Proc Natl Acad Sci U S A	2014
24927529	Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.	Proc Natl Acad Sci U S A	2014
24936658	The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.	PLoS One	2014
23806029	Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease.	Thyroid	2013
23667258	Structure-based discovery of antagonists of nuclear receptor LRH-1.	J Biol Chem	2013
23805258	Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization.	PLoS One	2013
21878368	A conserved surface on the ligand binding domain of nuclear receptors for allosteric control.	Mol Cell Endocrinol	2012
22984442	Structure of a novel winged-helix like domain from human NFRKB protein.	PLoS One	2012
22187462	Structural basis of coactivation of liver receptor homolog-1 by Î²-catenin.	Proc Natl Acad Sci U S A	2012
21730179	Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.	Proc Natl Acad Sci U S A	2011
21949357	Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.	Proc Natl Acad Sci U S A	2011
20335180	Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.	J Biol Chem	2010
21041940	Decoration of microtubules in solution by the kinesin-14, Ncd.	Acta Crystallogr D Biol Crystallogr	2010
20493816	Conformation switching of clathrin light chain regulates clathrin lattice assembly.	Dev Cell	2010
20179344	Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.	Acta Crystallogr D Biol Crystallogr	2010
18988706	Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.	Mol Endocrinol	2009
19416847	Structure of the complex of a mitotic kinesin with its calcium binding regulator.	Proc Natl Acad Sci U S A	2009
18798561	Molecular basis for dimer formation of TRbeta variant D355R.	Proteins	2009
18513992	Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein.	J Struct Biol	2008
18790740	Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.	J Biol Chem	2008
18754610	6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.	J Med Chem	2008
19015525	The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.	Proc Natl Acad Sci U S A	2008
17502099	The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.	Structure	2007
23484530	Perspectives on designs of antiandrogens for prostate cancer.	Expert Opin Drug Discov	2007
17918822	Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.	J Med Chem	2007
18007036	Interaction between the androgen receptor and a segment of its corepressor SHP.	Acta Crystallogr D Biol Crystallogr	2007
17823305	Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.	Mol Endocrinol	2007
17278355	Ca ion and the troponin switch.	Adv Exp Med Biol	2007
16469331	An atomic model of the thin filament in the relaxed and Ca2+-activated states.	J Mol Biol	2006
16804159	A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.	Sci STKE	2006
16962610	Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.	J Mol Biol	2006
16864794	Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.	Proc Natl Acad Sci U S A	2006
16415057	Dynamics of the C-terminal region of TnI in the troponin complex in solution.	Biophys J	2006
15707893	Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.	Cell	2005
16263725	Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.	J Biol Chem	2005
16359432	Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer.	BJU Int	2005

1 - 50 of 269

Jeffrey B Bonanno

Albert Einstein College of Medicine

Career Start Year 1999

Number of shared co-authors 7

Sergey M Vorobiev

Columbia University

Career Start Year 1998

Number of shared co-authors 3

Orly Dym

Weizmann Institute of Science

Career Start Year 1995

Number of shared co-authors 5

Clemens Vonrhein

Global Phasing Ltd

Career Start Year 1995

Number of shared co-authors 1

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 2

Hee-Won Park

Kangwon National University College of Medicine

Career Start Year 1993

Number of shared co-authors 4

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 19

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Career Start Year 1989

Number of shared co-authors 4

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 11

Liang Tong

Columbia University

Career Start Year 1988

Number of shared co-authors 7

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 1

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 19

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 3

Mark S Johnson

Abo Akademi University

Career Start Year 1985

Number of shared co-authors 2

Aled M Edwards

University of Toronto

Career Start Year 1984

Number of shared co-authors 8

Mamoru Sato

Yokohama City University

Career Start Year 1982

Number of shared co-authors 1

Vladimir N Malashkevich

Albert Einstein College of Medicine

Career Start Year 1982

Number of shared co-authors 1

Stephen K Burley

The State University of New Jersey

Career Start Year 1982

Number of shared co-authors 11

John Kuriyan

University of California berkeley

Career Start Year 1982

Number of shared co-authors 4

Udo Heinemann

Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)

Career Start Year 1980

Number of shared co-authors 4

Ivan Rayment

College of Agricultural and Life Sciences, University of Wisconsin-Madison

Career Start Year 1976

Number of shared co-authors 2

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 7

Martino Bolognesi

University of Milano

Career Start Year 1975

Number of shared co-authors 2

George N Phillips

Rice University

Career Start Year 1974

Number of shared co-authors 2

Dino Moras

Laboratory IGBMC (Institute of Genetics and of Molecular and Cellular Biology)

Career Start Year 1973

Number of shared co-authors 0

Joel L Sussman

Weizmann Institute of Science

Career Start Year 1971

Number of shared co-authors 5

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 2

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 4

Sung-Hou Kim

University of California berkeley

Career Start Year 1967

Number of shared co-authors 5

David Eisenberg

university of california los angeles

Career Start Year 1963

Number of shared co-authors 4

row(s) 1 - 30 of 30

Charles S Craik

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 37

Fred E Cohen

University of California san francisco

Co-authored papers 13

Stanley B Prusiner

Weill Institute for Neurosciences, University of California San Francisco

Co-authored papers 11

Phuong Nguyen

Hoag Memorial Hospital Presbyterian

Co-authored papers 9

Christopher B Newgard

Duke Molecular Physiology Institute

Co-authored papers 7

Linda S Brinen

The Joint Center for Structural Genomics, Stanford University

Co-authored papers 6

James H McKerrow

Sandler Center for Drug Discovery, University of California San Francisco

Co-authored papers 6

Ashley M Deacon

Accelero Biostructures Inc., USA XPose Therapeutics Inc.

Co-authored papers 5

Stephanie X Wang

University of California san francisco

Co-authored papers 5

Hsiu-Ju Chiu

Joint Center for Structural Genomics

Co-authored papers 4

Matthew P Jacobson

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 4

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Co-authored papers 3

Debanu Das

Accelero Biostructures Inc., USA XPose Therapeutics Inc.

Co-authored papers 3

Marc-Andr?? Elsliger

Joint Center for Structural Genomics

Co-authored papers 3

Stuart Tugendreich

Co-authored papers 2

Adam Godzik

University of California Riverside

Co-authored papers 2

E Sigal

Institute of Biochemistry & Cell Biology

Co-authored papers 2

Philip J Rosenthal

University of California at San Francisco

Co-authored papers 2

Tharin M A Blumenschein

University of East Anglia

Co-authored papers 2

Robert Abarbanel

Co-authored papers 2

Scott A Lesley

Merck & Co., Inc.

Co-authored papers 2

Anang A Shelat

St. Jude Children's Research Hospital

Co-authored papers 2

Jennifer L Harris

Co-authored papers 2

Barry Honig

Columbia University Irving Medical Center

Co-authored papers 2

David Baker

University of Washington

Co-authored papers 2

Kailash C Gupta

National Centre for Cell Science, SP Pune University Campus

Co-authored papers 2

Bruce R Conklin

Gladstone Institutes

Co-authored papers 2

David A Agard

University of California, USA Quantitative Biosciences Institute (QBI) san francisco

Co-authored papers 2

Carol L Farr

Joint Center for Structural Genomics

Co-authored papers 2

Lukasz Jaroszewski

University of California Riverside School of Medicine

Co-authored papers 1

1 - 30

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