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Author Details

Zhiguo Zhang
Institute for Cancer Genetics, Columbia University Irving Medical Center
1997
101
42
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37028413Histone chaperones: A multinodal highway network inside the cell.Mol Cell2023
37616371Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.Science2023
37467745Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.Cell Metab2023
36973430Specific regulation of BACH1 by the hotspot mutant p53<sup>R175H</sup> reveals a distinct gain-of-function mechanism.Nat Cancer2023
35102600Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II.EMBO J2022
35544640H3K4me3 recognition by the COMPASS complex facilitates the restoration of this histone mark following DNA replication.Sci Adv2022
35792957Mechanisms of chromatin-based epigenetic inheritance.Sci China Life Sci2022
35725587Publisher Correction: Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions.Nat Commun2022
35523900Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions.Nat Commun2022
35778827Rad53 arrests leading and lagging strand DNA synthesis via distinct mechanisms in response to DNA replication stress.Bioessays2022
36305747Epigenome Programming by H3.3K27M Mutation Creates a Dependence of Pediatric Glioma on SMARCA4.Cancer Discov2022
36354740Mcm2 promotes stem cell differentiation via its ability to bind H3-H4.Elife2022
34010645The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin.Cell Rep2021
33911256Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells.Nat Protoc2021
34531325A mechanism for Rad53 to couple leading- and lagging-strand DNA synthesis under replication stress in budding yeast.Proc Natl Acad Sci U S A2021
32923642DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands.Sci Adv2020
30922218Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq.BMC Genomics2019
31586391Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit.Nucleic Acids Res2019
31209047Pak2 kinase promotes cellular senescence and organismal aging.Proc Natl Acad Sci U S A2019
29292063Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity.Trends Biochem Sci2018
30054476A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma.Nat Commun2018
29915027Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation.Proc Natl Acad Sci U S A2018
29802243Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation.Nat Commun2018
30073537Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations.Methods Mol Biol2018
29932419H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.Elife2018
30115745A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.Science2018
30057113Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.Cell2018
30244834The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands.Mol Cell2018
29043628Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.Methods Mol Biol2018
27679476H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.Nucleic Acids Res2017
28107649RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.Mol Cell2017
28129023Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.Cell Cycle2017
29033319Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.Mol Cell2017
28934509Yeast CAF-1 assembles histone (H3-H4) 2 tetramers prior to DNA deposition.Nucleic Acids Res2017
29268714Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application.BMC Genomics2017
28784720Both DNA Polymerases δ and ε Contact Active and Stalled Replication Forks Differently.Mol Cell Biol2017
26972001Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins.Cell Rep2016
26376656Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR.J Neurooncol2016
27666592FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription.Mol Cell2016
27922816The progeroid gene BubR1 regulates axon myelination and motor function.Aging (Albany NY)2016
27803105BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer.Cancer Res2016
27229140The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.Science2016
27141053Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.Mol Cell Biol2016
27217568O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.Proc Natl Acad Sci U S A2016
26908650A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks.Nucleic Acids Res2016
27083998USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.Genes Dev2016
25365782Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases.Crit Rev Biochem Mol Biol2015
26318992Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Bioorg Med Chem Lett2015
25634295PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.J Med Chem2015
24573675The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast.J Biol Chem2014
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Co-authored papers 4
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Umea University
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The University of Texas at Austin
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University of California San Francisco
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Andre J van Wijnen
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Jennifer J Westendorf
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Benjamin Cheng
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Derek J Hook
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National Marine Biodiversity Institute of Korea
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James E Bradner
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Release 1.2