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Author Details

Ivaylo Ivanov
Georgia State University, GA 30302 USA Center for Diagnostics and Therapeutics
2002
80
33
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36477609A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair.Nucleic Acids Res2023
37179334Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases.Nat Commun2023
37264880Isolation and characterization of natural inhibitors of post-proline specific peptidases from the leaves of Cotinus coggygria Scop.J Ethnopharmacol2023
34853308Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.Nat Commun2021
32202798Simulation-Based Methods for Model Building and Refinement in Cryoelectron Microscopy.J Chem Inf Model2020
34046601Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases.RSC Med Chem2020
33097731Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path.Nat Commun2020
33007515Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.DNA Repair (Amst)2020
32669428Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.Proc Natl Acad Sci U S A2020
31051173Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps.J Mol Biol2019
31110295Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.Nat Struct Mol Biol2019
29784784Uncovering universal rules governing the selectivity of the archetypal DNA glycosylase TDG.Proc Natl Acad Sci U S A2018
30083386Structural visualization of RNA polymerase III transcription machineries.Cell Discov2018
29641204Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.J Med Chem2018
29389071Combinatorial Probes for High-Throughput Electrochemical Analysis of Circulating Nucleic Acids in Clinical Samples.Angew Chem Int Ed Engl2018
29610463Single-cell mRNA cytometry via sequence-specific nanoparticle clustering and trapping.Nat Chem2018
28623663Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.Elife2017
28230529Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1.Elife2017
28180310DNA microstructure influences selective binding of small molecules designed to target mixed-site DNA sequences.Nucleic Acids Res2017
28649316Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.Medchemcomm2017
27109703Secondary Interaction Interfaces with PCNA Control Conformational Switching of DNA Polymerase PolB from Polymerization to Editing.J Phys Chem B2016
26553876Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.J Biol Chem2016
27241473Rational design of a protein that binds integrin αvβ3 outside the ligand binding site.Nat Commun2016
27263093Effect of acute hypoxic shock on the rat brain morphology and tripeptidyl peptidase I activity.Acta Histochem2016
27262595Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.Bioorg Med Chem Lett2016
27193682Near-atomic resolution visualization of human transcription promoter opening.Nature2016
27513828DNA Clutch Probes for Circulating Tumor DNA Analysis.J Am Chem Soc2016
26715749Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.Proc Natl Acad Sci U S A2016
25377874Nanoparticle-mediated binning and profiling of heterogeneous circulating tumor cell subpopulations.Angew Chem Int Ed Engl2015
26557958Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution.Comput Struct Biotechnol J2015
26100805An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum.Nat Chem2015
25905604Bifunctionalized Allenes. Part XVI. Synthesis of 3-Phosphoryl-2,5-dihydrofurans by Coinage Metal-Catalyzed Cyclo-isomerization of Phosphorylated α-Hydroxyallenes.Molecules2015
26009151Sample-to-Answer Isolation and mRNA Profiling of Circulating Tumor Cells.Anal Chem2015
26004442Functional dynamics in replication protein A DNA binding and protein recruitment domains.Structure2015
25773143Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response.Structure2015
24564570Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.J Med Chem2014
24992034Alkylpurine glycosylase D employs DNA sculpting as a strategy to extrude and excise damaged bases.PLoS Comput Biol2014
25076142Bifunctionalized allenes. Part XV. Synthesis of 2,5-dihydro-1,2-oxaphospholes by electrophilic cyclization reaction of phosphorylated α-hydroxyallenes.Molecules2014
24840901Bifunctionalized allenes. Part XIII. A convenient and efficient method for regioselective synthesis of phosphorylated α-hydroxyallenes with protected and unprotected hydroxy group.Molecules2014
23303776A new structural framework for integrating replication protein A into DNA processing machinery.Nucleic Acids Res2013
24038358Opening pathways of the DNA clamps proliferating cell nuclear antigen and Rad9-Rad1-Hus1.Nucleic Acids Res2013
23783571Probing DNA clamps with single-molecule force spectroscopy.Nucleic Acids Res2013
23167816Chip-based nanostructured sensors enable accurate identification and classification of circulating tumor cells in prostate cancer patient blood samples.Anal Chem2013
23247167Enzyme cofactors: double-edged sword for catalysis.Nat Chem2013
23355472Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.J Biol Chem2013
22185679Comparison of the activity levels and localization of dipeptidyl peptidase IV in normal and tumor human lung cells.Tissue Cell2012
23007433Molecular dynamics.Methods Mol Biol2012
22586102Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.Proc Natl Acad Sci U S A2012
21244835Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel.Biophys J2011
21996941Developmental study of tripeptidyl peptidase I activity in the mouse central nervous system and peripheral organs.Cell Tissue Res2011
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Collaborators

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and Center for Structural Biology, Vanderbilt University
Co-authored papers 3
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Institute of Molecular Biology "Roumen Tsanev",Bulgarian Academy of Sciences
Co-authored papers 2
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College of Pharmaceutical Sciences, Zhejian University
Co-authored papers 1
University of Missouri
Co-authored papers 1
Ottawa Institute of Systems Biology, Carleton University
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
University of California
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University of California San Francisco
Co-authored papers 1
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Carleton University
Co-authored papers 1
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
C. H. Best Institute, University of Toronto
Co-authored papers 1
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University of Toronto
Co-authored papers 1
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