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Author Details

Susan L Hamilton
Baylor College of Medicine
1977
119
53
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37709832Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.Commun Biol2023
35697689Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility.Nat Commun2022
33403543Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients.Can J Anaesth2021
33905995How mutations in RYR1 that cause malignant hyperthermia increase RYR1 sensitivity to activators.Cell Calcium2021
33786938Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation.FASEB J2021
33037202Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation.Nat Commun2020
33198807MyoSight-semi-automated image analysis of skeletal muscle cross sections.Skelet Muscle2020
33190635Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature.Skelet Muscle2020
29930394TRPV1 variants impair intracellular Ca<sup>2+</sup> signaling and may confer susceptibility to malignant hyperthermia.Genet Med2019
28337975A chemical chaperone improves muscle function in mice with a RyR1 mutation.Nat Commun2017
25575511The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function.Hum Mol Genet2015
26245899Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.J Biol Chem2015
25717360Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.Skelet Muscle2015
25053409Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.J Biol Chem2014
25614869Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility.Mol Genet Genomic Med2014
25611019Improving awareness of nonanesthesia-related malignant hyperthermia presentations: a tale of two brothers.A A Case Rep2014
23364397Exome sequencing reveals SCO2 mutations in a family presented with fatal infantile hyperthermia.J Hum Genet2013
24004537Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin.Skelet Muscle2013
23773997MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development.Hum Mol Genet2013
23798496Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia.J Physiol2013
22231556AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.Nat Med2012
20544946Effect of prior exercise on thermal sensitivity of malignant hyperthermia-susceptible muscle.Muscle Nerve2010
20961976Ryanodine receptors: structure, expression, molecular details, and function in calcium release.Cold Spring Harb Perspect Biol2010
18927076Ryanodine receptor structure: progress and challenges.J Biol Chem2009
19966218Characterization and temporal development of cores in a mouse model of malignant hyperthermia.Proc Natl Acad Sci U S A2009
19473981Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin.J Biol Chem2009
19279214Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins.Proc Natl Acad Sci U S A2009
19246389A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice.Proc Natl Acad Sci U S A2009
18394989RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice.Cell2008
19081378Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.Neuron2008
18787086Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice.J Appl Physiol (1985)2008
18511525FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury.J Appl Physiol (1985)2008
18621707Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel.Proc Natl Acad Sci U S A2008
18199822Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK.J Neurophysiol2008
17261647FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure.Hypertension2007
18193641Diseases associated with altered ryanodine receptor activity.Subcell Biochem2007
16284304Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.FASEB J2006
17071618Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1.J Biol Chem2006
16873551Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.Proc Natl Acad Sci U S A2006
16685765Regulation of voltage-gated Ca2+ channels by calmodulin.Sci STKE2006
16227507A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity.Biophys J2006
15496482Calmodulin interactions with IQ peptides from voltage-dependent calcium channels.Am J Physiol Cell Physiol2005
16115682Ryanodine receptors.Cell Calcium2005
16338416Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel.Structure2005
16369047Regulation of voltage-gated Ca2+ channels by calmodulin.Sci STKE2005
15998242Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels.Antioxid Redox Signal2005
16084392The pore structure of the closed RyR1 channel.Structure2005
15583004Sites on calmodulin that interact with the C-terminal tail of Cav1.2 channel.J Biol Chem2005
15581887Structure of Ca2+ release channel at 14 A resolution.J Mol Biol2005
14672973Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle.J Appl Physiol (1985)2004
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Collaborators

McGovern Medical School at The University of Texas Health Science Center at Houston
Co-authored papers 11
Stanford University
Co-authored papers 8
Co-authored papers 7
Baylor College of Medicine
Co-authored papers 5
McGovern Medical School at the University of Texas Health Science Center
Co-authored papers 4
Co-authored papers 3
Co-authored papers 2
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University of California San Francisco
Co-authored papers 1
University of Tennessee Health Science Center
Co-authored papers 1
Baylor College of Medicine
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Baylor College of Medicine
Co-authored papers 1
Vanderbilt University Medical Center
Co-authored papers 1
Translational and Clinical Research Institute, Newcastle University
Co-authored papers 1
Leibniz-Institut fur Virologie (LIV)
Co-authored papers 1
Purdue University. Electronic address: .
Co-authored papers 1
University of Tennessee Health Sciences Centre
Co-authored papers 1
Co-authored papers 1
Baylor College of Medicine.
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
University of California at San Francisco
Co-authored papers 1
Co-authored papers 1
University of Chinese Academy of Sciences
Co-authored papers 1