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Author Details

Sina Ghaemmaghami
University of Rochester
1998
50
25
PMIDPaper TitleJournal TitlePublished Year
37966721Long lifetime and tissue-specific accumulation of lamin A/C in Hutchinson-Gilford progeria syndrome.J Cell Biol2024
36929723Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes.Mol Syst Biol2023
38064566In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.Sci Adv2023
37162946Long lifetime and selective accumulation of the A-type lamins accounts for the tissue specificity of Hutchinson-Gilford progeria syndrome.bioRxiv2023
35584362Accurate Proteomewide Measurement of Methionine Oxidation in Aging Mouse Brains.J Proteome Res2022
33369227MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.EMBO Mol Med2021
33639418Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.Mol Cell Proteomics2021
34079900Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization.ACS Cent Sci2021
32612191Global analysis of protein degradation in prion infected cells.Sci Rep2020
31801345Quantitative Analysis of in Vivo Methionine Oxidation of the Human Proteome.J Proteome Res2020
33144500Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain.Proc Natl Acad Sci U S A2020
32719387Publisher Correction: Global analysis of protein degradation in prion infected cells.Sci Rep2020
32744136Methionine oxidation within the prion protein.Prion2020
30846556Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome.Proc Natl Acad Sci U S A2019
30810280JNK modifies neuronal metabolism to promote proteostasis and longevity.Aging Cell2019
29321186Cross-species Comparison of Proteome Turnover Kinetics.Mol Cell Proteomics2018
30044219Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in <i>Drosophila</i> embryos.Elife2018
29503614Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice.Front Aging Neurosci2018
27920025Biology and Genetics of PrP Prion Strains.Cold Spring Harb Perspect Med2017
29133406Proteome-wide modulation of degradation dynamics in response to growth arrest.Proc Natl Acad Sci U S A2017
28673962Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.Biochem J2017
26947064Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy.Cell Rep2016
26650791Ion-Current-Based Temporal Proteomic Profiling of Influenza-A-Virus-Infected Mouse Lungs Revealed Underlying Mechanisms of Altered Integrity of the Lung Microvascular Barrier.J Proteome Res2016
27765818Time-resolved Analysis of Proteome Dynamics by Tandem Mass Tags and Stable Isotope Labeling in Cell Culture (TMT-SILAC) Hyperplexing.Mol Cell Proteomics2016
27248575Global analysis of cellular protein flux quantifies the selectivity of basal autophagy.Autophagy2016
24791984Analysis of proteome dynamics in mice by isotopic labeling.Methods Mol Biol2014
25301408Kinetics of precursor labeling in stable isotope labeling in cell cultures (SILAC) experiments.Anal Chem2014
24762293Successes and challenges in phenotype-based lead discovery for prion diseases.J Med Chem2014
23438476Convergent replication of mouse synthetic prion strains.Am J Pathol2013
24059341Strain specificity and drug resistance in anti-prion therapy.Curr Top Med Chem2013
24183589Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.Bioorg Med Chem2013
22444387Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling.Anal Chem2012
23344724Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.Mol Ther Nucleic Acids2012
22768295Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.PLoS One2012
21610081A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.J Biol Chem2011
21839745Conformational transformation and selection of synthetic prion strains.J Mol Biol2011
21937731A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling.Mol Cell Proteomics2011
20032192Discovery of 2-aminothiazoles as potent antiprion compounds.J Virol2010
20699386Analysis of proteome dynamics in the mouse brain.Proc Natl Acad Sci U S A2010
19955177Chemical induction of misfolded prion protein conformers in cell culture.J Biol Chem2010
19213877Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.Science2009
19956709Continuous quinacrine treatment results in the formation of drug-resistant prions.PLoS Pathog2009
17989223Cell division modulates prion accumulation in cultured cells.Proc Natl Acad Sci U S A2007
16699522Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.Nature2006
18629296Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.Comp Funct Genomics2005
14562106Global analysis of protein expression in yeast.Nature2003
12197709A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution.J Am Chem Soc2002
11573094Quantitative protein stability measurement in vivo.Nat Struct Biol2001
10890887A quantitative, high-throughput screen for protein stability.Proc Natl Acad Sci U S A2000
9636065Folding kinetics of a fluorescent variant of monomeric lambda repressor.Biochemistry1998
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Collaborators

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John J Irwin
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Abby Oehler
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Nabora S Reyes
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