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| 35266827 | An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase. | Antimicrob Agents Chemother | 2022 |
| 33318657 | Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax. | Br J Cancer | 2021 |
| 33887438 | Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition. | Bioorg Med Chem Lett | 2021 |
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| 33914534 | Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. | J Med Chem | 2021 |
| 34468177 | The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking <i>De Novo</i> Formation of the Membranous Replication Compartment. | J Virol | 2021 |
| 34719594 | Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator. | Chem Pharm Bull (Tokyo) | 2021 |
| 34452102 | Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme. | Pharmaceutics | 2021 |
| 33414172 | Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth. | Cancer Res | 2021 |
| 31509234 | Inhibition of tissue-nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD-MBD mouse model. | J Pathol | 2020 |
| 31882297 | Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma. | Bioorg Med Chem Lett | 2020 |
| 32360899 | Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization impairment. | Bone | 2020 |
| 32470395 | β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. | Cell | 2020 |
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| 30771432 | Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells. | Cancer Lett | 2019 |
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| 30208056 | Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization. | PLoS One | 2018 |
| 30308156 | Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis. | Cell Host Microbe | 2018 |
| 28543567 | TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. | Hepatology | 2017 |
| 28461069 | Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists. | Antiviral Res | 2017 |
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| 28346406 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. | Nat Chem Biol | 2017 |
| 29416592 | Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. | Oncotarget | 2017 |
| 29023576 | Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia. | PLoS One | 2017 |
| 28881801 | A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer. | Oncotarget | 2017 |
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| 28522407 | High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. | Biochem Pharmacol | 2017 |
| 27119457 | ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. | ACS Chem Biol | 2016 |
| 26642438 | PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. | Nat Med | 2016 |
| 25544056 | Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines. | ACS Chem Neurosci | 2015 |
| 26603897 | SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. | Cancer Res | 2015 |
| 26046436 | Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. | Cell | 2015 |
| 25946346 | Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. | ACS Chem Biol | 2015 |
| 25675381 | Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target. | J Clin Endocrinol Metab | 2015 |
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| 25530830 | Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. | ACS Med Chem Lett | 2014 |
| 25382610 | Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia. | Blood Cancer J | 2014 |
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| 24412070 | Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. | Bioorg Med Chem Lett | 2014 |
| 23035722 | Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11. | Pigment Cell Melanoma Res | 2013 |
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