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Author Details

Lily Jun-Shen Huang
University of Texas Southwestern Medical Center
1997
44
26
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37491347Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice.Nat Commun2023
31399524Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis.Haematologica2020
33101709MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation.Cell Death Discov2020
32983414Erythropoietin regulation of red blood cell production: from bench to bedside and back.F1000Res2020
32556132A master erythroid regulator gets its own GPS.Blood2020
30528456Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.EBioMedicine2019
29187371Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.Am J Physiol Renal Physiol2018
27941793Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.Nat Med2017
28507533Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K.Front Endocrinol (Lausanne)2017
28868519Dynamic Change of Transcription Pausing through Modulating NELF Protein Stability Regulates Granulocytic Differentiation.Blood Adv2017
28057939Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm.Leukemia2017
27029346Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.Biochem J2016
26166573Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.Cell Rep2015
26314863Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity.Elife2015
24569476Structural basis for the prion-like MAVS filaments in antiviral innate immunity.Elife2014
25158716Genome editing of mouse fibroblasts by homologous recombination for sustained secretion of PDGF-B and augmentation of wound healing.Plast Reconstr Surg2014
23592968Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure.PLoS Comput Biol2013
24129700Using functional signature ontology (FUSION) to identify mechanisms of action for natural products.Sci Signal2013
24113870Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.Blood2013
23970166Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity.Integr Biol (Camb)2013
23636173The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection.Kidney Int2013
21183685Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor.J Biol Chem2011
21237494Erythroblastic sarcoma presenting as bilateral ovarian masses in an infant with pure erythroid leukemia.Hum Pathol2011
20000429Chemical and biological studies of nakiterpiosin and nakiterpiosinone.J Am Chem Soc2010
20679397Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta.Genes Dev2010
20594592Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia.Leuk Res2010
19929856A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F).Biochem J2010
20096014Advances in understanding the pathogenesis of primary familial and congenital polycythaemia.Br J Haematol2010
19336760Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia.Blood2009
19638629A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.J Biol Chem2009
18158285Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.J Biol Chem2008
17581630Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.EMBO J2007
17052978The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms.J Biol Chem2006
11997044Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation.FEBS Lett2002
11387330Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.J Biol Chem2001
11239466The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif.Mol Cell2001
11779507The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.Mol Cell2001
11716788PKA, PKC, and AKAP localization in and around the neuromuscular junction.BMC Neurosci2001
10352013NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum.J Cell Biol1999
10230394Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A.Mol Cell1999
9857038Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping.J Biol Chem1998
9756917Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit.J Biol Chem1998
9065479Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits.J Biol Chem1997
9326583D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.Proc Natl Acad Sci U S A1997
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Collaborators

University of California
Co-authored papers 7
Virginia Commonwealth University
Co-authored papers 6
University of Washington
Co-authored papers 2
Howard Hughes Medical Institute
Co-authored papers 2
National Center for Microscopy and Imaging Research, University of California
Co-authored papers 2
Co-authored papers 2
St. Jude Children's Research Hospital
Co-authored papers 2
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Co-authored papers 2
School of Pharmacy, University of Waterloo
Co-authored papers 2
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Co-authored papers 1
The University of Texas Southwestern Medical Center
Co-authored papers 1
Institute of Biomedical Science and Children's Hospital, Fudan University
Co-authored papers 1
Stanford University
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
Seoul National University
Co-authored papers 1
Department of Radiology- Johns Hopkins University School of Medicine
Co-authored papers 1
university of california san diego
Co-authored papers 1
Children's Hospital of Los Angeles
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
University of Nebraska Medical Center
Co-authored papers 1
Universidad Autonoma de San Luis Potosi
Co-authored papers 1
University of Georgia
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St. Jude Children's Research Hospital.
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UT Southwestern Medical Center
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