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Author Details

Sally Freeman
Division of Pharmacy and Optometry, University of Manchester
1988
83
22
PMIDPaper TitleJournal TitlePublished Year
37110551Tadalafil Rescues the p.M325T Mutant of Best1 Chloride Channel.Molecules2023
37570721Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels.Molecules2023
37764248Evaluation of 4-Aminoquinoline Hydrazone Analogues as Potential Leads for Drug-Resistant Malaria.Molecules2023
37216118Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.iScience2023
35290041SAR of Novel 3-Arylisoquinolinones: <i>meta</i>-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules.J Med Chem2022
36073607Targeting firing rate neuronal homeostasis can prevent seizures.Dis Model Mech2022
36173167Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation.Protein Sci2022
36234744A Selective Review and Virtual Screening Analysis of Natural Product Inhibitors of the NLRP3 Inflammasome.Molecules2022
34832380Selected Derivatives of Erythromycin B-<i>In Silico</i> and Anti-Malarial Studies.Materials (Basel)2021
33778168Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease.Biochem Biophys Rep2021
32512325Resveratrol-mediated cleavage of amyloid β<sub>1-42</sub> peptide: potential relevance to Alzheimer's disease.Neurobiol Aging2020
34094411Selective inhibition of the K<sup>+</sup> efflux sensitive NLRP3 pathway by Cl<sup>-</sup> channel modulation.Chem Sci2020
33255820Inhibiting the NLRP3 Inflammasome.Molecules2020
33216713LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.Elife2020
31514018Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).Eur J Med Chem2019
29331080Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.ChemMedChem2018
29969573Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?SLAS Discov2018
30100651Radiosynthesis and reactivity of <i>N</i>-[<sup>11</sup>C]methyl carbamoylimidazole.J Radioanal Nucl Chem2018
29527108Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid.Med Chem Res2018
29567345Evaluation of analogues of furan-amidines as inhibitors of NQO2.Bioorg Med Chem Lett2018
29618797Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.Sci Rep2018
28595067Pentapeptides for the treatment of small cell lung cancer: Optimisation by N<sup>ind</sup>-alkyl modification of the tryptophan side chain.Eur J Med Chem2017
30108771<i>N-tert</i>-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer.Medchemcomm2017
28943355Boron-Based Inhibitors of the NLRP3 Inflammasome.Cell Chem Biol2017
28976921In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates.Molecules2017
26854376Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria.Eur J Med Chem2016
26422006Inhibiting the Inflammasome: A Chemical Perspective.J Med Chem2016
27509875Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.Nat Commun2016
24290974Detection of apoptosis by PET/CT with the diethyl ester of [[18]F]ML-10 and fluorescence imaging with a dansyl analogue.Bioorg Med Chem2014
24637781Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-fluoro-DPD; a novel potent inhibitor of signalling.Chem Commun (Camb)2014
23042766AMT (3-(2-aminopropyl)indole) and 5-IT (5-(2-aminopropyl)indole): an analytical challenge and implications for forensic analysis.Drug Test Anal2013
22578527myo-Inositol esters of indomethacin as COX-2 inhibitors.Carbohydr Res2012
22618019Fluorescent probe for detection of bacteria: conformational trigger upon bacterial reduction of an azo bridge.Chem Commun (Camb)2012
21324566Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.Eur J Med Chem2011
21960541Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones.Drug Test Anal2011
20428590Conformational analysis of the natural iron chelator myo-inositol 1,2,3-trisphosphate using a pyrene-based fluorescent mimic.Org Biomol Chem2010
20886463The naphyrone story: The alpha or beta-naphthyl isomer?Drug Test Anal2010
20648523Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry.Drug Test Anal2010
20307979Synthesis and bioluminescence-inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomer.Bioorg Med Chem Lett2010
18762996"Chelatable iron pool": inositol 1,2,3-trisphosphate fulfils the conditions required to be a safe cellular iron ligand.J Biol Inorg Chem2009
19592003Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry.J Chromatogr A2009
17870212Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.Eur J Med Chem2008
18823897Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.J Chromatogr A2008
18821252PAMAM dendrimers for the delivery of the antibacterial Triclosan.J Enzyme Inhib Med Chem2008
18956055Fluorescent probe: complexation of Fe3+ with the myo-inositol 1,2,3-trisphosphate motif.Chem Commun (Camb)2008
18455334Halogenated solvent interactions with N,N-dimethyltryptamine: formation of quaternary ammonium salts and their artificially induced rearrangements during analysis.Forensic Sci Int2008
18480912Exciplex and excimer molecular probes: detection of conformational flip in a myo-inositol chair.Org Biomol Chem2008
18242916N,N-Dimethyltryptamine and dichloromethane: rearrangement of quaternary ammonium salt product during GC-EI and CI-MS-MS analysis.J Pharm Biomed Anal2008
18083027In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand.Bioorg Med Chem Lett2008
17188439In vitro evaluation of dendrimer prodrugs for oral drug delivery.Int J Pharm2007
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Collaborators

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University
Co-authored papers 13
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The University of Manchester
Co-authored papers 4
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
Co-authored papers 3
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University
Co-authored papers 2
The University of Manchester
Co-authored papers 2
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Blavatnik Institute, Harvard Medical School
Co-authored papers 1
Seattle Children's Hospital, University of Washington
Co-authored papers 1