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Author Details

Elizabeth A Winzeler
University of California San Diego
1991
225
65
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37995692Antiplasmodial peptaibols act through membrane directed mechanisms.Cell Chem Biol2024
36927839Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Nat Commun2023
37750720Whole-genome surveillance identifies markers of <i>Plasmodium falciparum</i> drug resistance and novel genomic regions under selection in Mozambique.mBio2023
37652975Antimalarial drug discovery: progress and approaches.Nat Rev Drug Discov2023
37546892Reaction hijacking inhibition of <i>Plasmodium falciparum</i> asparagine tRNA synthetase.Res Sq2023
37737220Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.Elife2023
37018842Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development.Annu Rev Microbiol2023
37172592Human nuclear hormone receptor activity contributes to malaria parasite liver stage development.Cell Chem Biol2023
36888694Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.Sci Transl Med2023
36919909Human Polo-like Kinase Inhibitors as Antiplasmodials.ACS Infect Dis2023
368531907-<i>N</i>-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome <i>bc</i><sub>1</sub> Complex.ACS Infect Dis2023
36617500Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors.Chemistry2023
36763526Fast-Killing Tyrosine Amide ((<i>S</i>)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (<i>Pf</i>CARL).ACS Infect Dis2023
34233174The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.Cell Chem Biol2022
35653481Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.Science2022
35344575A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.PLoS Pathog2022
35600849Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.Front Pharmacol2022
36129427Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.ChemMedChem2022
36228458New targets for antimalarial drug discovery.Curr Opin Microbiol2022
36260689The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple <i>Plasmodium</i> kinases and life cycle stages.Sci Transl Med2022
36008486Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.Nat Commun2022
35149760Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.Commun Biol2022
34348113Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.Cell Chem Biol2022
33360801Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity.Eur J Med Chem2021
33715347PfMFR3: A Multidrug-Resistant Modulator in <i>Plasmodium falciparum</i>.ACS Infect Dis2021
33573376Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite <i>Plasmodium falciparum</i> and Optimization Efforts.J Med Chem2021
33876936Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.J Med Chem2021
33648890MalDA, Accelerating Malaria Drug Discovery.Trends Parasitol2021
33620219Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>.J Med Chem2021
33483532Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.Sci Rep2021
34471283Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases.Nat Rev Drug Discov2021
34523908Prioritization of Molecular Targets for Antimalarial Drug Discovery.ACS Infect Dis2021
34548400Design of proteasome inhibitors with oral efficacy in vivo against <i>Plasmodium falciparum</i> and selectivity over the human proteasome.Proc Natl Acad Sci U S A2021
34460304The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite.Antimicrob Agents Chemother2021
31616928A Novel Antiparasitic Compound Kills Ring-Stage Plasmodium falciparum and Retains Activity Against Artemisinin-Resistant Parasites.J Infect Dis2020
31813848Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.Cell Chem Biol2020
31998692Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage <i>P. falciparum</i> Including <i>Pf</i>KI3 C580Y Mutants and Liver Stage <i>P. berghei</i> Parasites.Front Chem2020
32078764Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.ACS Infect Dis2020
33219324Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases.Commun Biol2020
33293381The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.mBio2020
33064992SnapShot: Antimalarial Drugs.Cell2020
32945666Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-<i>b</i>]pyridines.J Med Chem2020
32682267The antimalarial resistome - finding new drug targets and their modes of action.Curr Opin Microbiol2020
32905749Genomic Approaches to Drug Resistance in Malaria.Annu Rev Microbiol2020
32732306Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage Response.G3 (Bethesda)2020
32359426Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.Cell Chem Biol2020
32286267Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.Nat Commun2020
30700707Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection.Nat Commun2019
31640748Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections.Genome Med2019
31806760Evolution of resistance in vitro reveals mechanisms of artemisinin activity in <i>Toxoplasma gondii</i>.Proc Natl Acad Sci U S A2019
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Collaborators

Sabine Ottilie
University of California San Diego
Co-authored papers 29
Yingyao Zhou
Genomics Institute of the Novartis Research Foundation
Co-authored papers 28
Dyann F Wirth
The Broad Institute
Co-authored papers 26
Case W McNamara
a division of The Scripps Research Institute La Jolla
Co-authored papers 23
Madeline R Luth
University of California San Diego
Co-authored papers 21
Karine G Le Roch
Co-authored papers 16
Joseph M Vinetz
Yale University School of Medicine
Co-authored papers 15
Amanda K Lukens
Harvard T.H. Chan School of Public Health
Co-authored papers 15
Kelli Kuhen
Genomics Institute of the Novartis Research Foundation
Co-authored papers 14
Ronald W Davis
Stanford University
Co-authored papers 12
Gregory M Goldgof
University of California san francisco
Co-authored papers 10
Manu Vanaerschot
Columbia University Irving Medical Center
Co-authored papers 8
Matthew Abraham
University of California
Co-authored papers 8
Edgar Vigil
University of California
Co-authored papers 7
Serge Batalov
Co-authored papers 7
Alan H Fairlamb
University of Dundee
Co-authored papers 7
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 6
Jennifer Yang
Chang Gung Memorial Hospital
Co-authored papers 5
John R Yates
TheScripps Research Institute
Co-authored papers 5
William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 4
Daniel J Carucci
US Military Malaria Vaccine Program, Naval Medical Research Center
Co-authored papers 4
Nathanael S Gray
Harvard Medical School
Co-authored papers 4
Felicia Gunawan
University of California
Co-authored papers 4
Stuart L Schreiber
Broad Institute
Co-authored papers 3
Roy M Williams
University of California
Co-authored papers 3
Ghislain M C Bonamy
Prestige BioPharma Ltd
Co-authored papers 3
Jacob D Durrant
University of Pittsburgh
Co-authored papers 3
Andrea L Cheung
University of California
Co-authored papers 3
Prianka Kumar
The George Washington University School of Medicine and Health Sciences
Co-authored papers 3
Krypton Carolino
University of California
Co-authored papers 3
Release 1.2