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Author Details

Kurtis E Bachman
1999
53
35
PMIDPaper TitleJournal TitlePublished Year
33288543Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts.Journal of Immunology2021
34279934Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.Journal of Medicinal Chemistry2021
31088836DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.Cancer Res2019
29765031Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.Nat Commun2018
30138347A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells.PLoS ONE2018
30181297Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic.Proc Natl Acad Sci U S A2018
29203668Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.Proc Natl Acad Sci U S A2017
29127145TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.Journal of Immunology2017
23708506Lapatinib inhibits the growth of esophageal squamous cell carcinoma and synergistically interacts with 5-fluorouracil in patient-derived xenograft models.Oncology Reports2013
23251242Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma.Experimental and Therapeutic Medicine (discontinued)2013
22169769Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.Molecular Cancer Therapeutics2012
22892846Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth.Cancer Biology and Therapy2012
22421194Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood.Clin Cancer Res2012
22949843Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma.International Journal of Molecular Sciences2012
22003129Subtype and pathway specific responses to anticancer compounds in breast cancer.Proc Natl Acad Sci U S A2012
21600279Mutation and copy number detection in human cancers using a custom genotyping assay.Genomics2011
21762492High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916.Journal of Translational Medicine2011
21987798Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.Proc Natl Acad Sci U S A2011
20406975Molecular target class is predictive of in vitro response profile.Cancer Research2010
20571075Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability.Mol Cancer Ther2010
20562907Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response.Oncogene2010
20382522Catalogue, cause, complexity and cure; the many uses of cancer genome sequence.Current Opinion in Genetics and Development2010
19843859Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.Cancer Res2009
19196980Knockin of mutant PIK3CA activates multiple oncogenic pathways.Proc Natl Acad Sci U S A2009
18162533Tamoxifen-stimulated growth of breast cancer due to p21 loss.Proc Natl Acad Sci U S A2008
18630893Identification and validation of human DNA ligase inhibitors using computer-aided drug design.Journal of Medicinal Chemistry2008
17082796Persistent mismatch repair deficiency following targeted correction of hMLH1.Cancer Gene Ther2007
17611398P21 gene knock down does not identify genetic effectors seen with gene knock out.Cancer Biol Ther2007
17332347High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.Cancer Research2007
17438369The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation.Cancer Biology and Therapy2007
17875684Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.Cancer Res2007
16423997De novo CpG island methylation in human cancer cells.Cancer Res2006
16959974The consensus coding sequences of human breast and colorectal cancers.Science2006
16619041Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells.Oncogene2006
16449998Mutation of the PIK3CA oncogene in human cancers.Br J Cancer2006
16541319Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.Breast Cancer Res Treat2006
16982740MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles.Cancer Res2006
15956261Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells.Mol Cancer Ther2005
15608513Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter.Curr Opin Oncol2005
16007089Distinct epigenetic changes in the stromal cells of breast cancers.Nat Genet2005
14726675p21(WAF1/CIP1) mediates the growth response to TGF-beta in human epithelial cells.Cancer Biol Ther2004
15254419The PIK3CA gene is mutated with high frequency in human breast cancers.Cancer Biol Ther2004
12697822The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1.Mol Cell Biol2003
12559178Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.Cancer Cell2003
11932749DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.Nature2002
11779840Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density.Genome Res2002
11257100Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.Hum Mol Genet2001
11427539Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin.J Biol Chem2001
11420732DNA methylation, chromatin inheritance, and cancer.Oncogene2001
10913614Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients.FEBS Letters2000
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