Author details

Full Name

Kristen J Brennand

Affiliation

ORCID

Career Start Year

2007

Papers

134

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37454787	Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders.	Biol Psychiatry	2024
34493831	Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk.	Mol Psychiatry	2023
37824614	Multi-omic profiling of the developing human cerebral cortex at the single-cell level.		2023
37811875	Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome.		2023
37082147	Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies.	Cell Genom	2023
37076454	Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.		2023
37126998	Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder.	Eur Neuropsychopharmacol	2023
36868190	Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain.		2023
36993466	Non-additive effects of schizophrenia risk genes reflect convergent downstream function.		2023
37104592	The functional and evolutionary impacts of human-specific deletions in conserved elements.	Science	2023
37503149	R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription.		2023
37502907	Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes.		2023
36658083	Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders.		2023
35120616	Quickly moving too slowly: Interneuron migration in Timothy Syndrome.		2022
35459277	Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia.	Nat Commun	2022
36171428	The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease.	Nat Neurosci	2022
36289231	Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.	Nature Communications	2022
35891396	Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection.	Viruses	2022
35491564	Using Stem Cell Models to Explore the Genetics Underlying Psychiatric Disorders: Linking Risk Variants, Genes, and Biology in Brain Disease.	American Journal of Psychiatry	2022
36064543	A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.	NPJ Genom Med	2022
36506088	Reduced expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome.		2022
35045295	A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.	Cell Rep	2022
34895699	Prenatal Î¿-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation.	Biological Psychiatry	2022
34883504	Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia.	Complex Psychiatry	2021
34176589	Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective.	Biol Psychiatry	2021
33636110	Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection.	Stem Cell Reports	2021
34010781	Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia.	Current Opinion in Neurobiology	2021
33903248	Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes.	Proc Natl Acad Sci U S A	2021
33523961	Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets.	Sci Adv	2021
33783914	Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor.	Hum Mutat	2021
33674753	Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies.	Mol Psychiatry	2021
34151300	Using the dCas9-KRAB system to repress gene expression in hiPSC-derived <i>NGN2</i> neurons.	STAR Protoc	2021
34100031	IL10RB as a key regulator of COVID-19 host susceptibility and severity.	medRxiv	2021
33662268	Xenopus models suggest convergence of gene signatures on neurogenesis in autism.	Neuron	2021
33238137	Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease.	Neuron	2021
33131715	Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome.	Biological Psychiatry	2021
33432232	Analysis framework and experimental design for evaluating synergy-driving gene expression.	Nat Protoc	2021
31277978	CRISPR-based functional evaluation of schizophrenia risk variants.	Schizophrenia Research	2020
32203467	Modeling the complex genetic architectures of brain disease.	Nature Genetics	2020
32024766	Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems.	Journal of Neuroscience	2020
32313122	If there is not one cure for schizophrenia, there may be many.	Schizophrenia	2020
32066695	Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development.	Transl Psychiatry	2020
32065989	ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs.	J Neurosci Methods	2020
32304628	Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression.	Neuron	2020
31988434	A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.	Mol Psychiatry	2020
32152537	A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.	Nature Neuroscience	2020
32712198	Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics.	Molecular and Cellular Neurosciences	2020
33199899	Massively parallel techniques for cataloguing the regulome of the human brain.	Nature Neuroscience	2020
32578147	Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.	Advances in neurobiology	2020
32516938	Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.	Cells	2020