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Author Details

Keiko Akagi
The University of Texas MD Anderson Cancer Center
1997
56
35
PMIDPaper TitleJournal TitlePublished Year
36715691Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration.Cancer Discov2023
37004423Noninvasive genomic profiling of somatic mutations in oral cavity cancers.Oral Oncol2023
31958486Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma.Cancer Lett2020
30563911Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.Genome Res2019
30957677Identification of Rare Variants Predisposing to Thyroid Cancer.Thyroid2019
30626753Variations in HPV function are associated with survival in squamous cell carcinoma.JCI Insight2019
29449315Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity.Cold Spring Harb Mol Case Stud2018
29364907HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression.PLoS Genet2018
28049147Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma.mBio2017
28252665Chromatin states shape insertion profiles of the piggyBac, Tol2 and Sleeping Beauty transposons and murine leukemia virus.Sci Rep2017
28215705KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.Cell2017
28790199In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.Circ Res2017
27498558Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.Nat Commun2016
25918370Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.Proc Natl Acad Sci U S A2015
26135620A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition.Sci Rep2015
24201445Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.Genome Res2014
25423036Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis.PLoS One2014
25043004Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.Nature2014
24493738An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition.Nucleic Acids Res2014
23319453How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.Bioessays2013
23690926Ultra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.PLoS One2013
23539728SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.J Clin Endocrinol Metab2013
22343890Clonal selection drives genetic divergence of metastatic medulloblastoma.Nature2012
22722832The bonobo genome compared with the chimpanzee and human genomes.Nature2012
22367191Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance.Genome Res2012
21163920Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Blood2011
22020066A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.Nat Methods2011
21946536Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.Nat Med2011
21474760Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I.Science2011
19933259MouseIndelDB: a database integrating genomic indel polymorphisms that distinguish mouse strains.Nucleic Acids Res2010
20927200An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.Genes Cancer2010
20194733Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.Proc Natl Acad Sci U S A2010
20233966Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.Blood2010
20388773Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas.Cancer Res2010
19234449A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.Nat Biotechnol2009
19843846Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.Cancer Res2009
19732750Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.Biochem Biophys Res Commun2009
19727076Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.Nature2009
19401450Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen.Cancer Res2009
19339698Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.Blood2009
19461887Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.PLoS Genet2009
19266325Gene targeting in mouse embryonic stem cells.Methods Mol Biol2009
18381897Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.Genome Res2008
16858412Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.EMBO J2006
16015321Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.Nature2005
16179923Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system.Nat Methods2005
15933056Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells.Blood2005
14681473RTCGD: retroviral tagged cancer gene database.Nucleic Acids Res2004
12393497Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.Blood2003
11836786Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus embryonic development.Dev Dyn2002
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Collaborators

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Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw
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Maria Sklodowska-Curie Institute - Oncology Center
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M. Sklodowska-Curie National Research Institute of Oncology
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The University of Texas MD Anderson Cancer Center
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Moores Cancer Center, University of California
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