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Author Details

Rachel Toth
University of Dundee
1999
85
43
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36941054Structure-based design and characterization of Parkin-activating mutations.Life Sci Alliance2023
37188479Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.Life Sci Alliance2023
35267011Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.J Cell Sci2022
35764390Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome.Life Sci Alliance2022
35857630An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.Sci Signal2022
35969127Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells.Biochem J2022
33980892Generation of a chemical genetic model for JAK3.Sci Rep2021
33795880Structural basis of FANCD2 deubiquitination by USP1-UAF1.Nat Struct Mol Biol2021
34605059CDKL5 kinase controls transcription-coupled responses to DNA damage.EMBO J2021
34780645An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.Biochem J2021
34767452Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.Sci Adv2021
34270554Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.PLoS One2021
32227113PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.Biochem J2020
31873223Allosteric mechanism for site-specific ubiquitination of FANCD2.Nat Chem Biol2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33080171Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.Dev Cell2020
32420600Characterization of FANCL variants observed in patient cancer cells.Biosci Rep2020
32239177A complex comprising C15ORF41 and Codanin-1: the products of two genes mutated in congenital dyserythropoietic anaemia type I (CDA-I).Biochem J2020
30850063Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins.Methods Enzymol2019
29742418RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.Cell Rep2018
30456385Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.Life Sci Alliance2018
30266825Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.EMBO J2018
30341347Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.Nat Commun2018
29449168Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544].DNA Repair (Amst)2018
27920213Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.Biochem J2017
28414322Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.Nat Struct Mol Biol2017
28445980The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.Oncotarget2017
29136188Corrigendum: Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.Nucleic Acids Res2017
28593137MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.FEBS Open Bio2017
28575657RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.Mol Cell2017
26797144Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.Science2016
27498864Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.Cell Rep2016
27244671The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.Elife2016
26980188Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice.Genes Dev2016
25723849Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.Biochem J2015
26499801Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders.J Biol Chem2015
26254304Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.EMBO J2015
26139536mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.EMBO J2015
2573577214-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides.Bioinformatics2015
25752573K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.Mol Cell2015
24501395ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome.Database (Oxford)2014
25303670Improved genome editing in human cell lines using the CRISPR method.PLoS One2014
24768767GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins.Cell Signal2014
23241891PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.J Immunol2013
24076219Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.Mol Cell2013
24176932Loss of iron triggers PINK1/Parkin-independent mitophagy.EMBO Rep2013
23918981Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.J Immunol2013
23994477Localization-dependent and -independent roles of SLX4 in regulating telomeres.Cell Rep2013
23463102PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.EMBO J2013
22007846Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.Biochem J2012
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Collaborators

Charles James Hastie
University of Dundee
Co-authored papers 8
Dario R Alessi
University of Dundee
Co-authored papers 6
Clare Johnson
College of Life Sciences, University of Dundee
Co-authored papers 3
Fiona Brown
University of Dundee
Co-authored papers 3
Chris P Ponting
The University of Edinburgh
Co-authored papers 2
Nathanael S Gray
Harvard Medical School
Co-authored papers 2
Paul Davies
University of Dundee
Co-authored papers 2
Carla Baillie
University of Dundee
Co-authored papers 2
Luis Sanchez-Pulido
MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh
Co-authored papers 2
Samantha Raggett
University of Dundee
Co-authored papers 2
James E Haber
Brandeis University
Co-authored papers 2
Hannes Braberg
University of California San Francisco
Co-authored papers 1
Matthew Elliott
College of Life Sciences, University of Dundee
Co-authored papers 1
Gregory E Merz
University of California san francisco
Co-authored papers 1
J. Wade Harper
Harvard Medical School
Co-authored papers 1
Zun Zar Chi Naing
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 1
Jiewei Xu
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Nadia Herrera
University of California san francisco
Co-authored papers 1
Ming Sun
Columbia University
Co-authored papers 1
Loan Doan
University of California san francisco
Co-authored papers 1
Maliheh Safari
University of California san francisco
Co-authored papers 1
Anthony J Hodder
University of Sheffield
Co-authored papers 1
Justin T Biel
University of California san francisco
Co-authored papers 1
Ishan Deshpande
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Fengbo Zhou
Washington University School of Medicine
Co-authored papers 1
David E Gordon
Emory University
Co-authored papers 1
Tristan W Owens
University of California san francisco
Co-authored papers 1
Thomas Kehrer
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Kerry Burness
College of Life Sciences, University of Dundee
Co-authored papers 1
Elena Moreno
Icahn School of Medicine at Mount Sinai
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Release 1.2