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Author Details

Jamal C Saeh
Oncology R&D
2005
21
15
PMIDPaper TitleJournal TitlePublished Year
37443114BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.Mol Cancer2023
37486983First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma.Mol Cancer Ther2023
37289191Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer.Clin Cancer Res2023
33259592Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas.Blood2021
33495510Design and optimisation of dendrimer-conjugated Bcl-2/x<sub>L</sub> inhibitor, AZD0466, with improved therapeutic index for cancer therapy.Commun Biol2021
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
31699827AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells.Clin Cancer Res2020
28974548Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action.Clin Cancer Res2017
25890801Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists.Bioorg Med Chem Lett2015
26291341Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.J Med Chem2015
24631189Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.Bioorg Med Chem Lett2014
24881567Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.Bioorg Med Chem Lett2014
23272696Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.ACS Chem Biol2013
24900749Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.ACS Med Chem Lett2013
24320998Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).J Med Chem2013
22264476Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.Bioorg Med Chem Lett2012
22649101Essential role of TAK1 in regulating mantle cell lymphoma survival.Blood2012
22277784Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.Sci Transl Med2012
16884290Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring.J Med Chem2006
16045307Lead hopping using SVM and 3D pharmacophore fingerprints.J Chem Inf Model2005
15945625Equation-of-motion coupled-cluster methods for ionized states with an approximate treatment of triple excitations.J Chem Phys2005
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Collaborators

Edward J Hennessy
Oncology R&D
Co-authored papers 7
Kate F Byth
Oncology R&D
Co-authored papers 6
Justin Cidado
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Co-authored papers 4
Ammar Adam
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Co-authored papers 4
Stephen Fawell
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Co-authored papers 4
Terry MacIntyre
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Co-authored papers 4
Shenghua Wen
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Co-authored papers 3
Gareth P Gregory
School of Clinical Sciences at Monash Health, Monash University
Co-authored papers 2
J Paul Secrist
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Co-authored papers 2
Francis D Gibbons
Preclinical and Translational Sciences, Inc.
Co-authored papers 2
Jeffrey G Varnes
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Co-authored papers 2
Barry R Davies
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Co-authored papers 2
Thomas W Gero
Dana-Farber Cancer Institute
Co-authored papers 2
Eric Gangl
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Co-authored papers 2
Ricky W Johnstone
The University of Melbourne
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Steven W Criscione
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Stephanos Ioannidis
H3 Biomedicine Inc.
Co-authored papers 2
Martin Wild
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Co-authored papers 2
Alwin G Schuller
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Co-authored papers 2
Nancy Su
Co-authored papers 2
Paula Lewis
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Co-authored papers 2
Robert B Diebold
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Co-authored papers 2
Michael Zinda
Repare Therapeutics Inc.
Co-authored papers 2
William McCoull
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Co-authored papers 2
Mathew J Garnett
Wellcome Sanger Institute
Co-authored papers 1
Anthony J Iafrate
Massachusetts General Hospital
Co-authored papers 1
Patricia Jaaks
Wellcome Sanger Institute
Co-authored papers 1
Lucienne Ronco
Co-authored papers 1
David M Weinstock
Merck & Co.
Co-authored papers 1
Kathleen Burke
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Release 1.2