Author details

Full Name

H Kirk Hammond

Affiliation

ORCID

Career Start Year

1983

Papers

114

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37433214	Effects of Gene Transfer on Glucose Disposal in Insulin-Resistant db/db Mice on Metformin.		2023
37127773	Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.		2023
36053712	Gene Transfer for Systolic and Diastolic Dysfunction Due to Chronically Increased Left Ventricular Pressure.	Human Gene Therapy	2022
34509087	Transvenous occlusion of patent ductus arteriosus in a domestic chicken (Gallus gallus).	Journal of Veterinary Cardiology	2021
31676153	Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice.	Molecular Therapy	2020
32188720	Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease.	Science Translational Medicine	2020
30731143	Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction.	Life Sciences	2019
31790421	Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance.	PLoS ONE	2019
30003813	Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart.	Human Gene Therapy	2019
30648430	Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice.	Hum Gene Ther	2019
30638074	Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (<i>C1C2</i>) Attenuates Deleterious Effects of Pressure Overload.	Hum Gene Ther	2019
31173603	Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.	PLoS ONE	2019
29763816	Design of a Phase 3 trial of intracoronary administration of human adenovirus 5 encoding human adenylyl cyclase type 6 (RT-100) gene transfer in patients with heart failure with reduced left ventricular ejection fraction: The FLOURISH Clinical Trial.	Am Heart J	2018
30062211	Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal.	JACC: Basic to Translational Science	2018
28322590	Randomized Clinical Trials of Gene Transfer for Heart Failure with Reduced Ejection Fraction.	Human Gene Therapy	2017
28767701	Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained Î²-adrenergic stimulation.	PLoS ONE	2017
28498861	Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits.	PLoS ONE	2017
27537778	Clinical Evaluation of Heart Failure: Agreement among Tests.	PLoS One	2016
28670631	Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation.	JACC: Basic to Translational Science	2016
27437887	Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial.	JAMA Cardiol	2016
27699250	One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance.	JCI insight	2016
25760560	Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice.	Human Gene Therapy	2015
24277577	Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo.	FASEB Journal	2014
23609114	Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.	Circulation Research	2013
24147149	Preserved cardiac function despite marked impairment of cAMP generation.	PLoS ONE	2013
23931341	Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice.	Human Gene Therapy	2013
24091324	Integrins protect cardiomyocytes from ischemia/reperfusion injury.	J Clin Invest	2013
23587598	Adenylyl cyclase 6 deletion increases mortality during sustained Î²-adrenergic receptor stimulation.	J Mol Cell Cardiol	2013
23261978	Gene transfer for congestive heart failure: update 2013.		2013
23123217	Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.	American Journal of Pathology	2013
22017392	Improved function of the failing rat heart by regulated expression of insulin-like growth factor I via intramuscular gene transfer.	Human Gene Therapy	2012
22966786	Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer.	Human gene therapy methods	2012
22534469	Prospects for gene transfer for clinical heart failure.	Gene Therapy	2012
21982317	Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression.	J Am Coll Cardiol	2011
21354173	Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer.	Journal of Molecular and Cellular Cardiology	2011
21127130	Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.	Molecular Pharmacology	2011
21195051	Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.	Biochemical and Biophysical Research Communications	2011
21282557	Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.	Hypertension	2011
21527160	Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts.	Journal of the American College of Cardiology	2011
22051336	Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function.	Journal of the American College of Cardiology	2011
20359598	Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.	Journal of the American College of Cardiology	2010
20864687	Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla.	J Am Soc Nephrol	2010
20709863	Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy.	Am J Physiol Heart Circ Physiol	2010
20431059	Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.	Circulation Research	2010
19932173	beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling.	Cellular Signalling	2010
21701699	Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got?	Dialogues in Cardiovascular Medicine	2009
18838385	Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.	Journal of Biological Chemistry	2008
18948082	Galphaq reduces cAMP production by decreasing Galphas protein abundance.	Biochemical and Biophysical Research Communications	2008
18071070	Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.	Circulation	2008
18402905	Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice.	Journal of the American College of Cardiology	2008