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Author Details

Christine A Pratilas
Johns Hopkins University School of Medicine
2004
81
31
PMIDPaper TitleJournal TitlePublished Year
36799629MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors.Clin Cancer Res2023
38000020CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors.Sci Adv2023
37616542Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.Mol Cancer Ther2023
37549914Adolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.J Natl Compr Canc Netw2023
37841697Plexiform neurofibroma of the liver, with malignant transformation to MPNST, in a pediatric patient without neurofibromatosis type 1.Neurooncol Adv2023
37246765Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology.Neuro Oncol2023
37410426CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression.Clin Cancer Res2023
37372318Complex/cryptic <i>EWSR1::FLI1/ERG</i> Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas.Genes (Basel)2023
36821126Diffuse Pulmonary Metastases at Presentation of Giant Cell Tumor of Bone: A Case Report and Synthesis of Literature.JBJS Case Connect2023
36854806Integrated molecular and clinical analysis of BRAF-mutant glioma in adults.NPJ Precis Oncol2023
36476600Unresectable Metastatic Testicular Germ Cell Tumor With Low-grade Neuroglial Neoplasm, Stable After Radiation and Chemotherapy.Appl Immunohistochem Mol Morphol2023
36778419CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors.bioRxiv2023
34841430Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling.Dis Model Mech2022
35740680Therapeutic Vulnerability to ATR Inhibition in Concurrent <i>NF1</i> and <i>ATRX</i>-Deficient/ALT-Positive High-Grade Solid Tumors.Cancers (Basel)2022
35466567Trends of lymph node sampling and metastasis in pediatric and young adult patients with clear cell, epithelioid, and synovial sarcomas.Pediatr Blood Cancer2022
35534540Correction: Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma.Oncogene2022
35395680Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG).Neuro Oncol2022
35459782Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma.Oncogene2022
36322658Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy.Sci Adv2022
35184066Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma.Am J Surg Pathol2022
35244537Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma.Elife2022
34966100Considerations in Methods and Timing for Delivery of Genetic Counseling Information to Pediatric Oncology Patients and Families.J Pediatr Hematol Oncol2022
33203698Activation of Receptor Tyrosine Kinases Mediates Acquired Resistance to MEK Inhibition in Malignant Peripheral Nerve Sheath Tumors.Cancer Res2021
33591953Chromosome 8 gain is associated with high-grade transformation in MPNST.JCI Insight2021
34433654Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF[V600E]-Mutant Human Glioma.Clin Cancer Res2021
34021032Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes.J Immunother Cancer2021
34210658Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed <i>ALK</i> F1174L-mutated neuroblastoma.Cold Spring Harb Mol Case Stud2021
33953640Predictors of Recurrence and Patterns of Initial Failure in Localized Ewing Sarcoma: A Contemporary 20-Year Experience.Sarcoma2021
33229458Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor.Clin Cancer Res2021
33370000Improving Detection of Cancer Predisposition Syndromes in Pediatric Oncology.J Pediatr Hematol Oncol2021
31408245A novel RBMX-TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor.Genes Chromosomes Cancer2020
32098059Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1.Genes (Basel)2020
33032988Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors.Cancer Res2020
33028642<i>DICER1</i>-associated metastatic abdominopelvic primitive neuroectodermal tumor with an <i>EWSR1</i> rearrangement in a 16-yr-old female.Cold Spring Harb Mol Case Stud2020
33235998Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma.Neurooncol Adv2020
32939963Socioeconomic and health care coverage disparities in children, adolescents, and young adults with sarcoma.Pediatr Blood Cancer2020
32599735From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor.Genes (Basel)2020
32882803Special Issue: "Genomics and Models of Nerve Sheath Tumors".Genes (Basel)2020
32238401BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition.Cold Spring Harb Mol Case Stud2020
32561749A clinically and genomically annotated nerve sheath tumor biospecimen repository.Sci Data2020
32395555FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways.Ann Transl Med2020
31158244Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition.PLoS One2019
31466300BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors.Cancers (Basel)2019
31462295Telomere alterations in neurofibromatosis type 1-associated solid tumors.Acta Neuropathol Commun2019
31192863Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status.Am J Surg Pathol2019
31506385A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory <i>BRAF</i> V600 Mutation-Positive Solid Tumors.Clin Cancer Res2019
30842593Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.Nat Cell Biol2019
28859862The promise of signal transduction in genetically driven sarcomas of the nerve.Exp Neurol2018
29975249Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum.Am J Surg Pathol2018
29880583A Secondary Mutation in <i>BRAF</i> Confers Resistance to RAF Inhibition in a <i>BRAF</i><sup>V600E</sup>-Mutant Brain Tumor.Cancer Discov2018
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Collaborators

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Co-authored papers 13
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Co-authored papers 13
Memorial Sloan Kettering Cancer Center
Co-authored papers 9
University of California Los Angeles
Co-authored papers 8
Washington University School of Medicine and Siteman Cancer Center
Co-authored papers 8
The Johns Hopkins Hospital
Co-authored papers 7
Pacific Northwest National Laboratory (PNNL)
Co-authored papers 6
Siteman Cancer Center, Washington University School of Medicine
Co-authored papers 6
Johns Hopkins University School of Medicine
Co-authored papers 5
The Johns Hopkins Hospital
Co-authored papers 5
Memorial Sloan Kettering Cancer Center
Co-authored papers 5
Johns Hopkins University
Co-authored papers 5
Johns Hopkins University School of Medicine
Co-authored papers 4
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Children's Hospital at Montefiore.
Co-authored papers 4
Co-authored papers 4
Johns Hopkins University School of Medicine
Co-authored papers 4
Broad Institute of MIT and Harvard
Co-authored papers 4
University of Minnesota
Co-authored papers 3
Geisel School of Medicine, Dartmouth College
Co-authored papers 2
University of Washington
Co-authored papers 2
Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital
Co-authored papers 2
Johns Hopkins University School of Medicine
Co-authored papers 2
Wilmer Eye Institute, Johns Hopkins Medical Institutions
Co-authored papers 2
Co-authored papers 2
Johns Hopkins McKusick-Nathans Department of Genetic Medicine
Co-authored papers 2
Co-authored papers 2
Dana-Farber Cancer Institute
Co-authored papers 2
Broad Institute of Harvard and MIT
Co-authored papers 2
UW Medicine Diabetes Institute, University of Washington
Co-authored papers 2