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Author Details

Paul B Watkins
UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill
1984
268
83
PMIDPaper TitleJournal TitlePublished Year
38065572Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients.Clin Pharmacol Ther2024
36496055Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.Gastroenterology2023
37501650Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688.Clin Pharmacol Ther2023
37458709Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology.Clin Pharmacol Ther2023
36881043Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity.JAMA2023
36692187Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment.ALTEX2023
36733378Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.Front Pharmacol2023
35194822John R. Senior, MD.Hepatology2022
35611543Progress toward a universal biomedical data translator.Clin Transl Sci2022
35437723Quantitative Systems Toxicology and Drug Development: The DILIsym Experience.Methods Mol Biol2022
35556143Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.Toxicol Sci2022
36512576Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences.PLoS One2022
34910298Liver Injury Due to Drugs and Viruses: Mechanistic Similarities and Implications for AAV Gene Therapy.Clin Pharmacol Ther2022
32270503Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.Hepatology2021
33113257The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates.Clin Transl Sci2021
33135175Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.Clin Pharmacol Ther2021
32748396Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity.Clin Pharmacol Ther2021
32931777Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression.J Pharm Sci2021
33022751Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial.Clin Pharmacol Ther2021
31314926Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.Clin Pharmacol Ther2020
31644280Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics.J Med Chem2020
31753250Quantitative Systems Toxicology Approaches to Understand and Predict Drug-Induced Liver Injury.Clin Liver Dis2020
32024945HLA associations with infliximab-induced liver injury.Pharmacogenomics J2020
32037821Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury.J Med Chem2020
33035276Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse.PLoS One2020
32579200Mechanistic Investigations Support Liver Safety of Ubrogepant.Toxicol Sci2020
32768244Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.J Autoimmun2020
32895570Polygenic architecture informs potential vulnerability to drug-induced liver injury.Nat Med2020
32267996Rivaroxaban Precision Dosing Strategy for Real-World Atrial Fibrillation Patients.Clin Transl Sci2020
29357190Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.Hepatology2019
31501888Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach.Toxicol Sci2019
31388624Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury.Hepatol Commun2019
31624633Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.Pharmacol Res Perspect2019
31368504Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization.Toxicol Sci2019
31307586Idiosyncratic drug-induced liver injury in patients: Detection, severity assessment, and regulatory implications.Adv Pharmacol2019
31537107Safety and tolerability of ubrogepant following intermittent, high-frequency dosing: Randomized, placebo-controlled trial in healthy adults.Cephalalgia2019
30742832Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.Gastroenterology2019
30742679Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.PLoS One2019
31093666Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.Toxicol Sci2019
31066027Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.Clin Pharmacol Ther2019
30734107Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.Pharm Res2019
30762301The DILI-sim Initiative: Insights into Hepatotoxicity Mechanisms and Biomarker Interpretation.Clin Transl Sci2019
30880443Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program.Clin Trials2019
30378260Serum biomarkers of drug-induced liver injury: Current status and future directions.J Dig Dis2019
30601836Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.PLoS One2019
30289550Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.Toxicol Sci2019
30303523A Rapid Method to Estimate Hepatocyte Loss Due to Drug-Induced Liver Injury.Clin Pharmacol Ther2019
30468877Advancing nonclinical innovation and safety in pharmaceutical testing.Drug Discov Today2019
29069498Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).Toxicol Sci2018
29877622Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.Clin Transl Sci2018
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Collaborators

Mary F Paine
Washington State University
Co-authored papers 20
Danielle K Turgeon
The University of Michigan ann arbor
Co-authored papers 13
Paola Nicoletti
Icahn School of Medicine at Mount Sinai
Co-authored papers 7
Thomas J Urban
Eshelman School of Pharmacy, University of North Carolina
Co-authored papers 6
Jayant A Talwalkar
Mayo Clinic
Co-authored papers 6
Melvin E Andersen
Co-authored papers 5
Mary V Relling
Departments of Pharmaceutical Sciences.
Co-authored papers 4
Richard S Paules
Co-authored papers 4
Pierre R Bushel
Co-authored papers 4
Yufeng Shen
Columbia University
Co-authored papers 4
Mark S Boguski
Precision Medicine Network Inc.
Co-authored papers 3
Jeff W Chou
Co-authored papers 3
P Kuehl
University of Maryland at Baltimore
Co-authored papers 3
Elizabeth T Cirulli
Duke University
Co-authored papers 3
Elizabeth J Phillips
Vanderbilt University Medical Center
Co-authored papers 3
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Institute for Genomic Medicine, Columbia University Irving Medical Center
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Marcus Gry
AlbaNova University Center, KTH Royal Institute of Technology
Co-authored papers 2
Russell A Wilke
University of South Dakota Sanford School of Medicine
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Itsik Pe'er
Columbia University
Co-authored papers 2
Wensheng Guo
University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
Norman L Foster
University of Utah
Co-authored papers 2
Mark J Daly
Massachusetts General Hospital
Co-authored papers 2
Thomas Hartung
University of Konstanz
Co-authored papers 2
David W Threadgill
College Station
Co-authored papers 2
Christine M Hunt
Duke University Medical Center and Durham Veterans Affairs Health Care System
Co-authored papers 2
William Valdar
University of North Carolina at Chapel Hill
Co-authored papers 2
Kathleen M Giacomini
University of California San Francisco
Co-authored papers 1
Casey N Ta
Columbia University Irving Medical Center
Co-authored papers 1
Adam Johs
College of Computing and Informatics, Drexel University
Co-authored papers 1
Johan Lindberg
Karolinska Institute
Co-authored papers 1
Release 1.2