Skip to Main Content

Author Details

Charles Kent Osborne
1976
367
116
PMIDPaper TitleJournal TitlePublished Year
37195235A Multiparameter Molecular Classifier to Predict Response to Neoadjuvant Lapatinib plus Trastuzumab without Chemotherapy in HER2+ Breast Cancer.Clin Cancer Res2023
36716289Pertuzumab, Trastuzumab, and an Aromatase Inhibitor for HER2-Positive and Hormone Receptor-Positive Metastatic or Locally Advanced Breast Cancer: PERTAIN Final Analysis.2023
36827742Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer.2023
37467106High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer.Cell Rep2023
34645649Biomarkers of Response and Resistance to Palbociclib Plus Letrozole in Patients With ER/HER2 Breast Cancer.Clinical Cancer Research2022
36001024Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer.Cancer Discov2022
35860837Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer.Therapeutic Advances in Medical Oncology2022
36619972Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach.iScience2022
34470810Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer.Clin Cancer Res2021
33536276Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer.Clin Cancer Res2021
34045483Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models.npj Breast Cancer2021
34515904Management of hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer.Breast Cancer Research and Treatment2021
31037288HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade.J Natl Cancer Inst2020
32000054HER2-enriched subtype and pathological complete response in HER2-positive breast cancer: A systematic review and meta-analysis.2020
31662331TBCRC023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 versus 24 Weeks in Patients with HER2-Positive Breast Cancer.Clin Cancer Res2020
31917424Association Between 21-Gene Assay Recurrence Score and Locoregional Recurrence Rates in Patients With Node-Positive Breast Cancer.JAMA Oncol2020
31653641Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy.Clin Cancer Res2020
32675852DE-ESCALATING TREATMENT FOR HER2-POSITIVE EARLY BREAST CANCER.Transactions of the American Clinical and Climatological Association2020
30903140A combinatorial biomarker predicts pathologic complete response to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2+ breast cancer.Ann Oncol2019
30523750Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial.J Clin Oncol2019
30928413Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study.Clin Breast Cancer2019
31420371Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer.Mol Cancer Res2019
31218477Randomized controlled trial of high-dose versus standard-dose vitamin D3 for prevention of aromatase inhibitor-induced arthralgia.Breast Cancer Research and Treatment2019
31017314Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration.Histopathology2019
29574636GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer.Breast Cancer Research and Treatment2018
29045519Reply to 'The St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2017: the point of view of an International Panel of Experts in Radiation Oncology' by Kirova et al.Ann Oncol2018
30511015Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer.NPJ Breast Cancer2018
30106636First-Line Trastuzumab Plus an Aromatase Inhibitor, With or Without Pertuzumab, in Human Epidermal Growth Factor Receptor 2-Positive and Hormone Receptor-Positive Metastatic or Locally Advanced Breast Cancer (PERTAIN): A Randomized, Open-Label Phase II TrJournal of Clinical Oncology2018
29128193Vitamin D Levels, Vitamin D Receptor Polymorphisms, and Inflammatory Cytokines in Aromatase Inhibitor-Induced Arthralgias: An Analysis of CCTG MA.27.Clin Breast Cancer2018
29592880Trastuzumab-Resistant HER2<sup>+</sup> Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition.Mol Cancer Ther2018
29110152Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer.Breast Cancer Res Treat2018
29733336De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017.Ann Oncol2018
29578538Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.Nat Med2018
28196254Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial.JAMA - Journal of the American Medical Association2017
28730340CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study.Breast Cancer Res Treat2017
28729021ASCEND-8: A Randomized Phase 1 Study of Ceritinib, 450 mg or 600 mg, Taken with a Low-Fat Meal versus 750 mg in Fasted State in Patients with Anaplastic Lymphoma Kinase (ALK)-Rearranged Metastatic Non-Small Cell Lung Cancer (NSCLC).Journal of Thoracic Oncology2017
28687441De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance.Breast2017
28487443HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2<sup>+</sup> Breast Cancer.Clin Cancer Res2017
28838210De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017.Ann Oncol2017
27671678Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes.Cancer Res2016
28721378Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration.NPJ Breast Cancer2016
27393618Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.Breast Cancer Res Treat2016
26965145Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.Mol Cancer Res2016
26921331Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.Cancer Res2016
27791031FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.Proc Natl Acad Sci U S A2016
25208879Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.Clin Cancer Res2015
25587647Targeting HER2 for the treatment of breast cancer.Annual Review of Medicine2015
25698062An international study to increase concordance in Ki67 scoring.Mod Pathol2015
25537159A neoadjuvant, randomized, open-label phase II trial of afatinib versus trastuzumab versus lapatinib in patients with locally advanced HER2-positive breast cancer.Clinical Breast Cancer2015
25572662Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis.Breast Cancer Res2015
  • 1 - 50 of 367

Recommended Authors

Collaborators

Co-authored papers 82
Co-authored papers 50
Co-authored papers 47
German Cancer Research Center (DKFZ)
Co-authored papers 18
Co-authored papers 17
Co-authored papers 16
Co-authored papers 14
The University of Texas MD Anderson Cancer Center
Co-authored papers 12
Co-authored papers 12
Memorial Sloan-Kettering Cancer Center
Co-authored papers 10
Mayo Clinic
Co-authored papers 10
Co-authored papers 9
UCL Great Ormond Street Institute of Child Health, University College London
Co-authored papers 8
The University of Texas MD Anderson Cancer Center
Co-authored papers 8
Memorial Sloan Kettering Cancer Center
Co-authored papers 8
Co-authored papers 8
Baylor College of Medicine
Co-authored papers 7
Oregon Health and Science University
Co-authored papers 7
Co-authored papers 6
Oregon Health Sciences University
Co-authored papers 5
Co-authored papers 5
Co-authored papers 5
Co-authored papers 5
Dana-Farber Cancer Institute
Co-authored papers 5
Roswell Park Comprehensive Cancer Center
Co-authored papers 5
Mayo Clinic
Co-authored papers 5
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 5
Co-authored papers 4
Co-authored papers 4
Buck Institute for Research on Aging
Co-authored papers 4