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Author Details

David W Hedley
Princess Margaret Cancer Centre, University Health Network
1975
272
70
PMIDPaper TitleJournal TitlePublished Year
34990422Anal Adenocarcinoma: A Rare Entity in Need of Multidisciplinary Management.Dis Colon Rectum2022
35473998Pancreatic cancer growth promoted by bone marrow mesenchymal stromal cell-derived IL-6 is reversed predominantly by IL-6 blockade.Cytotherapy2022
36407947Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer.ACS Pharmacol Transl Sci2022
36636049A phase II trial of GSK2256098 and trametinib in patients with advanced pancreatic ductal adenocarcinoma.J Gastrointest Oncol2022
35869145Randomised, Phase II study of selumetinib, an oral inhibitor of MEK, in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer.Br J Cancer2022
35978831Digital quantitative tissue image analysis of hypoxia in resected pancreatic ductal adenocarcinomas.Front Oncol2022
35067501Impact of Definitive Chemoradiation on Quality-of-Life Changes for Patients With Anal Cancer: Long-term Results of a Prospective Study.Dis Colon Rectum2022
32897623An Iodinated DAPI-Based Reagent for Mass Cytometry.Chembiochem2021
33962950NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4.Sci Adv2021
33169241Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, <sup>111</sup>In or β-particle emitting, <sup>177</sup>Lu.EJNMMI Radiopharm Chem2020
32005829Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy.Sci Rep2020
32062317Radioimmunotherapy of human pancreatic cancer xenografts in NOD-scid mice with [<sup>64</sup>Cu]Cu-NOTA-panitumumab F(ab')<sub>2</sub> alone or combined with radiosensitizing gemcitabine and the PARP inhibitor, rucaparib.Nucl Med Biol2020
30686769Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.Cancer Cell2019
30117091Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients.J Gastrointest Cancer2019
31242384MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides To Enable Labeling with <sup>99m</sup>Tc(I) Tricarbonyl Complex.Mol Pharm2019
31520102Skin platinum deposition in colorectal cancer patients following oxaliplatin-based therapy.Cancer Chemother Pharmacol2019
31633216Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).Eur J Immunol2019
30654137Mobilization of Leukemic Cells Using Plerixafor as Part of a Myeloablative Preparative Regimen for Patients with Acute Myelogenous Leukemia Undergoing Allografting: Assessment of Safety and Tolerability.Biol Blood Marrow Transplant2019
30629588Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer.PLoS Comput Biol2019
30589553Radioimmunotherapy of PANC-1 Human Pancreatic Cancer Xenografts in NRG Mice with Panitumumab Modified with Metal-Chelating Polymers Complexed to <sup>177</sup>Lu.Mol Pharm2019
29288237Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.Clin Cancer Res2018
29755663The ongoing challenge of large anal cancers: prospective long term outcomes of intensity-modulated radiation therapy with concurrent chemotherapy.Oncotarget2018
29441441Comparison of Practice Guidelines, BRCAPRO, and Genetic Counselor Estimates to Identify Germline BRCA1 and BRCA2 Mutations in Pancreatic Cancer.J Genet Couns2018
29128266Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.Clin Colorectal Cancer2018
29314858Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to <sup>111</sup>In and <sup>177</sup>Lu-An EGFR-Targeted Theranostic for Pancreatic Cancer.Mol Pharm2018
27875522Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.Br J Cancer2017
33465927EGFR-Targeted Metal Chelating Polymers (MCPs) Harboring Multiple Pendant PEG<sub>2K</sub> Chains for MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts.ACS Biomater Sci Eng2017
28480074Long term responders to palliative chemotherapy for advanced biliary tract cancer.J Gastrointest Oncol2017
28160444Imaging Mass Cytometry.Cytometry A2017
28967989Staining of Frozen and Formalin-Fixed, Paraffin-Embedded Tissues with Metal-Labeled Antibodies for Imaging Mass Cytometry Analysis.Curr Protoc Cytom2017
29273939Impact of tissue transport on PET hypoxia quantification in pancreatic tumours.EJNMMI Res2017
29023707Guidelines for the use of flow cytometry and cell sorting in immunological studies.Eur J Immunol2017
27768182Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.JAMA Oncol2017
27902970Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.Oncotarget2017
27901496Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts.Oncotarget2017
26732437A phase I study of elesclomol sodium in patients with acute myeloid leukemia.Leuk Lymphoma2016
27812005Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues.Sci Rep2016
28033382Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.PLoS One2016
27779123Quantifying hypoxia in human cancers using static PET imaging.Phys Med Biol2016
27745984Phase 1/2 Study of the Addition of Cisplatin to Adjuvant Chemotherapy With Image Guided High-Precision Radiation Therapy for Completely Resected Gastric Cancer.Int J Radiat Oncol Biol Phys2016
27709819Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.Angew Chem Int Ed Engl2016
27422303A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer.Cancer Chemother Pharmacol2016
27552306Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study.J Biomed Opt2016
27467054FOLFIRINOX for advanced pancreatic cancer: the Princess Margaret Cancer Centre experience.Br J Cancer2016
27406088A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia.Invest New Drugs2016
27248663Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302.Oncotarget2016
27542226Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma.Oncotarget2016
26890070Cytokinetic effects of Wee1 disruption in pancreatic cancer.Cell Cycle2016
26686201A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI⿯9041).Invest New Drugs2016
26769863Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake.J Nucl Med2016
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Collaborators

Princess Margaret Cancer Centre
Co-authored papers 28
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 24
University Health Network, University of Toronto
Co-authored papers 20
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 18
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
Co-authored papers 17
Princess Margaret Cancer Centre, University Ave
Co-authored papers 16
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 16
Princess Margaret Cancer Centre
Co-authored papers 15
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
University of Toronto
Co-authored papers 10
Juravinski Hospital and Cancer Centre, Escarpment Cancer Research Institute
Co-authored papers 9
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 7
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 6
Co-authored papers 6
Ontario Institute for Cancer Research
Co-authored papers 6
Toronto General Hospital, University Health Network, University of Toronto
Co-authored papers 5
University of Toronto
Co-authored papers 5
Ontario Institute for Cancer Research
Co-authored papers 4
Ontario Institute for Cancer Research
Co-authored papers 4
St. Michael's Hospital, University of Toronto
Co-authored papers 4
University of Toronto.
Co-authored papers 4
University of Edinburgh
Co-authored papers 4
2Ontario Institute for Cancer Research
Co-authored papers 4
Princess Margaret Cancer Center
Co-authored papers 4
University of Toronto
Co-authored papers 4
University Health Network
Co-authored papers 3
Ontario Cancer Institute, University Health Network (UHN)
Co-authored papers 3
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Princess Margaret Cancer Centre
Co-authored papers 3
Princess Margaret Cancer Centre
Co-authored papers 3